PDE8A: Difference between revisions

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'''High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A''' is an [[enzyme]] that in humans is encoded by the ''PDE8A'' [[gene]].<ref name="pmid9618252">{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase | journal = Biochem Biophys Res Commun | volume = 246 | issue = 3 | pages = 570–7 |date=Jul 1998 | pmid = 9618252 | pmc =  | doi = 10.1006/bbrc.1998.8684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE8A phosphodiesterase 8A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151| accessdate = }}</ref> Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.<ref name="pmid21920574">{{cite journal | vauthors = Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, ((Strauss JF III)), Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB | title = Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages | journal = Virology |date=Sep 2011 | pmid = 21920574 | doi=10.1016/j.virol.2011.08.013 | volume=420 | issue=1 | pages=32–42}}</ref>
'''High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A''' is an [[enzyme]] that in humans is encoded by the ''PDE8A'' [[gene]].<ref name="pmid9618252">{{cite journal | vauthors = Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB | title = Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase | journal = Biochem Biophys Res Commun | volume = 246 | issue = 3 | pages = 570–7 |date=Jul 1998 | pmid = 9618252 | pmc =  | doi = 10.1006/bbrc.1998.8684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE8A phosphodiesterase 8A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5151| accessdate = }}</ref> Work by Sebastiaan Bol et al. showed that 5 different [[transcript variants]] and their corresponding [[isoforms]] are [[Gene expression|expressed]] in human [[Macrophage|macrophages]], and suggests that this protein may be required by [[HIV|HIV-1]] for its [[Viral replication|replication]].<ref name="pmid21920574">{{cite journal | vauthors = Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, ((Strauss JF III)), Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB | title = Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages | journal = Virology |date=Sep 2011 | pmid = 21920574 | doi=10.1016/j.virol.2011.08.013 | volume=420 | issue=1 | pages=32–42}}</ref>


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Revision as of 21:11, 5 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A is an enzyme that in humans is encoded by the PDE8A gene.[1][2] Work by Sebastiaan Bol et al. showed that 5 different transcript variants and their corresponding isoforms are expressed in human macrophages, and suggests that this protein may be required by HIV-1 for its replication.[3]


References

  1. Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB (Jul 1998). "Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase". Biochem Biophys Res Commun. 246 (3): 570–7. doi:10.1006/bbrc.1998.8684. PMID 9618252.
  2. "Entrez Gene: PDE8A phosphodiesterase 8A".
  3. Bol SM, Booiman T, Bunnik EM, Moerland PD, van Dort K, Strauss JF III, Sieberer M, Schuitemaker H, Kootstra NA, van 't Wout AB (Sep 2011). "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages". Virology. 420 (1): 32–42. doi:10.1016/j.virol.2011.08.013. PMID 21920574.

Further reading