4-aminobutyrate transaminase: Difference between revisions
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* [[Phenelzine]] | * [[Phenelzine]] | ||
* [[Phenylethylidenehydrazine]] (PEH) | * [[Phenylethylidenehydrazine]] (PEH) | ||
* [[Rosmarinic acid]]<ref>Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity | * [[Rosmarinic acid]]<ref>{{cite journal | vauthors = Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT | title = Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity | journal = Phytotherapy Research | volume = 23 | issue = 8 | pages = 1075–81 | date = August 2009 | pmid = 19165747 | doi = 10.1002/ptr.2712 }}</ref> | ||
* [[Valproic acid]] | * [[Valproic acid]] | ||
* [[Vigabatrin]] | * [[Vigabatrin]] | ||
==References== | == References == | ||
{{Reflist}} | {{Reflist}} | ||
* {{cite journal | vauthors = Scott EM, Jakoby WB | |||
* {{cite journal | | == Further reading == | ||
* {{cite journal | vauthors = Schousboe A, Wu JY, Roberts E | {{refbegin|32em}} | ||
* {{cite journal | vauthors = Scott EM, Jakoby WB | title = Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens | journal = The Journal of Biological Chemistry | volume = 234 | issue = 4 | pages = 932–6 | date = April 1959 | pmid = 13654294 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=13654294 }} | |||
* {{cite journal | vauthors = Aurich H | title = [On the beta-alanine-alpha-ketoglutarate transaminase from Neurospora crassa] | language = de | journal = Hoppe-Seyler's Zeitschrift für Physiologische Chemie | volume = 326 | pages = 25–33 | date = October 1961 | pmid = 13863304 | doi = 10.1515/bchm2.1961.326.1.25 | trans-title = On the beta-alanine-alpha-ketoglutarate transaminase from Neurospora crassa }} | |||
* {{cite journal | vauthors = Schousboe A, Wu JY, Roberts E | title = Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain | journal = Biochemistry | volume = 12 | issue = 15 | pages = 2868–73 | date = July 1973 | pmid = 4719123 | doi = 10.1021/bi00739a015 }} | |||
* {{cite journal | vauthors = Parviz M, Vogel K, Gibson KM, Pearl PL | title = Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies | journal = Journal of Pediatric Epilepsy | volume = 3 | issue = 4 | pages = 217–227 | date = November 2014 | pmid = 25485164 | pmc = 4256671 | doi = 10.3233/PEP-14097 | url = https://dash.harvard.edu/bitstream/handle/1/29361684/PARVIZ_MAHSA_GABA2014JPED_nihms-615766.pdf?sequence=1 }} | |||
{{refend}} | |||
== External links == | |||
{{Commonscat}} | |||
*{{MeshName|4-Aminobutyrate+Transaminase}} | |||
* Pearl, Phillip L., Parviz, Mahsa, Hodgeman, Ryan, Gibson, K. Michael. GABA-transaminase deficiency. In: Reimschisel T (ed.) MedLink Neurology. San Diego, California: MedLink Corporation. http://medlink.com/article/gaba-transaminase_deficiency | * Pearl, Phillip L., Parviz, Mahsa, Hodgeman, Ryan, Gibson, K. Michael. GABA-transaminase deficiency. In: Reimschisel T (ed.) MedLink Neurology. San Diego, California: MedLink Corporation. http://medlink.com/article/gaba-transaminase_deficiency | ||
{{Neurotransmitter metabolism enzymes}} | {{Neurotransmitter metabolism enzymes}} | ||
Revision as of 12:25, 4 November 2018
| 4-aminobutyrate transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:1ohv.jpg | |||||||||
| Identifiers | |||||||||
| EC number | 2.6.1.19 | ||||||||
| CAS number | 9037-67-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| 4-aminobutyrate transaminase | |
|---|---|
| Identifiers | |
| Symbol | ABAT |
| Entrez | 18 |
| HUGO | 23 |
| OMIM | 137150 |
| RefSeq | NM_020686 |
| UniProt | P80404 |
| Other data | |
| Locus | Chr. 16 p13.2 |
In enzymology, 4-aminobutyrate transaminase (EC 2.6.1.19), also called GABA transaminase or 4-aminobutyrate aminotransferase, is an enzyme that catalyzes the chemical reaction:
- 4-aminobutanoate + 2-oxoglutarate <math>\rightleftharpoons</math> succinate semialdehyde + L-glutamate
Thus, the two substrates of this enzyme are 4-aminobutanoate (GABA) and 2-oxoglutarate. The two products are succinate semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is 4-aminobutanoate:2-oxoglutarate aminotransferase. This enzyme participates in 5 metabolic pathways: alanine and aspartate metabolism, glutamate metabolism, beta-alanine metabolism, propanoate metabolism, and butanoate metabolism. It employs one cofactor, pyridoxal phosphate.
Structural Studies
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OHV, 1OHW, 1OHY, 1SF2, 1SFF, 1SZK, 1SZS, 1SZU, and 2EO5.
Inhibitors
- Aminooxyacetic acid
- Gabaculine
- Phenelzine
- Phenylethylidenehydrazine (PEH)
- Rosmarinic acid[1]
- Valproic acid
- Vigabatrin
References
- ↑ Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT (August 2009). "Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity". Phytotherapy Research. 23 (8): 1075–81. doi:10.1002/ptr.2712. PMID 19165747.
Further reading
- Scott EM, Jakoby WB (April 1959). "Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens". The Journal of Biological Chemistry. 234 (4): 932–6. PMID 13654294.
- Aurich H (October 1961). "[On the beta-alanine-alpha-ketoglutarate transaminase from Neurospora crassa]" [On the beta-alanine-alpha-ketoglutarate transaminase from Neurospora crassa]. Hoppe-Seyler's Zeitschrift für Physiologische Chemie (in Deutsch). 326: 25–33. doi:10.1515/bchm2.1961.326.1.25. PMID 13863304.
- Schousboe A, Wu JY, Roberts E (July 1973). "Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain". Biochemistry. 12 (15): 2868–73. doi:10.1021/bi00739a015. PMID 4719123.
- Parviz M, Vogel K, Gibson KM, Pearl PL (November 2014). "Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies" (PDF). Journal of Pediatric Epilepsy. 3 (4): 217–227. doi:10.3233/PEP-14097. PMC 4256671. PMID 25485164.
External links
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Wikimedia Commons has media related to [[commons:Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).|Lua error in Module:WikidataIB at line 428: attempt to index field 'wikibase' (a nil value).]]. |
- 4-Aminobutyrate+Transaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
- Pearl, Phillip L., Parviz, Mahsa, Hodgeman, Ryan, Gibson, K. Michael. GABA-transaminase deficiency. In: Reimschisel T (ed.) MedLink Neurology. San Diego, California: MedLink Corporation. http://medlink.com/article/gaba-transaminase_deficiency
Categories:
- Pages with script errors
- Pages with broken file links
- Protein pages needing a picture
- Genes on human chromosome 16
- CS1 Deutsch-language sources (de)
- Commons category link from Wikidata
- Portal templates with all redlinked portals
- EC 2.6.1
- Pyridoxal phosphate enzymes
- Enzymes of known structure
- GABA
- Glutamate (neurotransmitter)