SNTB2: Difference between revisions

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* {{cite journal | vauthors = Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M | title = The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells | journal = Eur. J. Cell Biol. | volume = 79 | issue = 9 | pages = 621–30 | year = 2001 | pmid = 11043403 | doi = 10.1078/0171-9335-00095 }}
* {{cite journal | vauthors = Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M | title = The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells | journal = Eur. J. Cell Biol. | volume = 79 | issue = 9 | pages = 621–30 | year = 2001 | pmid = 11043403 | doi = 10.1078/0171-9335-00095 }}
* {{cite journal | vauthors = Marchand S, Stetzkowski-Marden F, Cartaud J | title = Differential targeting of components of the dystrophin complex to the postsynaptic membrane | journal = Eur. J. Neurosci. | volume = 13 | issue = 2 | pages = 221–9 | year = 2001 | pmid = 11168526 | doi = 10.1046/j.1460-9568.2001.01373.x }}
* {{cite journal | vauthors = Marchand S, Stetzkowski-Marden F, Cartaud J | title = Differential targeting of components of the dystrophin complex to the postsynaptic membrane | journal = Eur. J. Neurosci. | volume = 13 | issue = 2 | pages = 221–9 | year = 2001 | pmid = 11168526 | doi = 10.1046/j.1460-9568.2001.01373.x }}
* {{cite journal | vauthors = Hogan A, Shepherd L, Chabot J, Quenneville S, Prescott SM, Topham MK, Gee SH | title = Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26526–33 | year = 2001 | pmid = 11352924 | doi = 10.1074/jbc.M104156200 }}
* {{cite journal | vauthors = Hogan A, Shepherd L, Chabot J, Quenneville S, Prescott SM, Topham MK, Gee SH | title = Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 26526–33 | year = 2001 | pmid = 11352924 | doi = 10.1074/jbc.M104156200 | url = http://www.jbc.org/content/276/28/26526.full.pdf }}
* {{cite journal | vauthors = Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M | title = Dephosphorylation of β2-syntrophin and Ca2+/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4013–23 | year = 2001 | pmid = 11483505 | pmc = 149140 | doi = 10.1093/emboj/20.15.4013 }}
* {{cite journal | vauthors = Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M | title = Dephosphorylation of β2-syntrophin and Ca2+/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4013–23 | year = 2001 | pmid = 11483505 | pmc = 149140 | doi = 10.1093/emboj/20.15.4013 }}
* {{cite journal | vauthors = Buechler C, Boettcher A, Bared SM, Probst MC, Schmitz G | title = The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 2 | pages = 759–65 | year = 2002 | pmid = 12054535 | doi = 10.1016/S0006-291X(02)00303-0 }}
* {{cite journal | vauthors = Buechler C, Boettcher A, Bared SM, Probst MC, Schmitz G | title = The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex | journal = Biochem. Biophys. Res. Commun. | volume = 293 | issue = 2 | pages = 759–65 | year = 2002 | pmid = 12054535 | doi = 10.1016/S0006-291X(02)00303-0 }}

Revision as of 01:59, 12 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene.[1][2][3]

Function

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes.[3]

Interactions

SNTB2 has been shown to interact with ABCA1.[4]

References

  1. ↑ Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM (March 1996). "The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives". J Biol Chem. 271 (5): 2724–30. doi:10.1074/jbc.271.5.2724. PMID 8576247.
  2. ↑ Ahn AH, Yoshida M, Anderson MS, Feener CA, Selig S, Hagiwara Y, Ozawa E, Kunkel LM (June 1994). "Cloning of human basic A1, a distinct 59-kDa dystrophin-associated protein encoded on chromosome 8q23-24". Proc Natl Acad Sci U S A. 91 (10): 4446–50. doi:10.1073/pnas.91.10.4446. PMC 43802. PMID 8183929.
  3. ↑ 3.0 3.1 "Entrez Gene: SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)".
  4. ↑ Buechler C, Boettcher A, Bared SM, Probst MC, Schmitz G (May 2002). "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex". Biochem. Biophys. Res. Commun. 293 (2): 759–65. doi:10.1016/S0006-291X(02)00303-0. PMID 12054535.

Further reading


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