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{{Infobox_gene}}
{{Infobox_gene}}
'''Serine/threonine-protein kinase TAO2''' is an [[enzyme]] that in humans is encoded by the ''TAOK2'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 | year = 1998 | date = May 1999 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="pmid9786855">{{cite journal | vauthors = Hutchison M, Berman KS, Cobb MH | title = Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades | journal = J. Biol. Chem. | volume = 273 | issue = 44 | pages = 28625–32 | date = Dec 1998 | pmid = 9786855 | pmc =  | doi = 10.1074/jbc.273.44.28625 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAOK2 TAO kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9344| accessdate = }}</ref>
'''Serine/threonine-protein kinase TAO2''' is an [[enzyme]] that in humans is encoded by the ''TAOK2'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = December 1998 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="pmid9786855">{{cite journal | vauthors = Hutchison M, Berman KS, Cobb MH | title = Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades | journal = The Journal of Biological Chemistry | volume = 273 | issue = 44 | pages = 28625–32 | date = October 1998 | pmid = 9786855 | pmc =  | doi = 10.1074/jbc.273.44.28625 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAOK2 TAO kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9344| access-date = }}</ref>


== Interactions ==
== Interactions ==


TAOK2 has been shown to [[Protein-protein interaction|interact]] with [[MAP2K6]]<ref name=pmid11279118>{{cite journal | vauthors = Chen Z, Cobb MH | title = Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16070–5 | date = May 2001 | pmid = 11279118 | doi = 10.1074/jbc.M100681200 }}</ref> and [[MAP2K3]].<ref name=pmid11279118/>
TAOK2 has been shown to [[Protein-protein interaction|interact]] with [[MAP2K6]]<ref name=pmid11279118>{{cite journal | vauthors = Chen Z, Cobb MH | title = Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 19 | pages = 16070–5 | date = May 2001 | pmid = 11279118 | doi = 10.1074/jbc.M100681200 }}</ref> and [[MAP2K3]].<ref name=pmid11279118/>


== References ==
== References ==
Line 11: Line 11:
== Further reading ==
== Further reading ==
{{Refbegin | 2}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Chen Z, Hutchison M, Cobb MH | title = Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain | journal = J. Biol. Chem. | volume = 274 | issue = 40 | pages = 28803–7 | year = 1999 | pmid = 10497253 | doi = 10.1074/jbc.274.40.28803 }}
* {{cite journal | vauthors = Chen Z, Hutchison M, Cobb MH | title = Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 40 | pages = 28803–7 | date = October 1999 | pmid = 10497253 | doi = 10.1074/jbc.274.40.28803 }}
* {{cite journal | vauthors = Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD | title = PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4311–22 | year = 2000 | pmid = 10660600 | doi = 10.1074/jbc.275.6.4311 }}
* {{cite journal | vauthors = Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD | title = PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization | journal = The Journal of Biological Chemistry | volume = 275 | issue = 6 | pages = 4311–22 | date = February 2000 | pmid = 10660600 | doi = 10.1074/jbc.275.6.4311 }}
* {{cite journal | vauthors = Chen Z, Cobb MH | title = Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16070–5 | year = 2001 | pmid = 11279118 | doi = 10.1074/jbc.M100681200 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = November 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
* {{cite journal | vauthors = Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD | title = The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 18085–91 | date = May 2003 | pmid = 12639963 | doi = 10.1074/jbc.M213064200 }}
* {{cite journal | vauthors = Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD | title = The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 18085–91 | year = 2003 | pmid = 12639963 | doi = 10.1074/jbc.M213064200 }}
* {{cite journal | vauthors = Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH | title = TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors | journal = The Journal of Biological Chemistry | volume = 278 | issue = 25 | pages = 22278–83 | date = June 2003 | pmid = 12665513 | doi = 10.1074/jbc.M301173200 }}
* {{cite journal | vauthors = Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH | title = TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22278–83 | year = 2003 | pmid = 12665513 | doi = 10.1074/jbc.M301173200 }}
* {{cite journal | vauthors = Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ | title = Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 | journal = Oncogene | volume = 22 | issue = 40 | pages = 6129–41 | date = September 2003 | pmid = 13679851 | doi = 10.1038/sj.onc.1206605 }}
* {{cite journal | vauthors = Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ | title = Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 | journal = Oncogene | volume = 22 | issue = 40 | pages = 6129–41 | year = 2003 | pmid = 13679851 | doi = 10.1038/sj.onc.1206605 }}
* {{cite journal | vauthors = Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J | title = Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways | journal = The Journal of Biological Chemistry | volume = 281 | issue = 39 | pages = 28802–10 | date = September 2006 | pmid = 16893890 | pmc = 1797068 | doi = 10.1074/jbc.M603627200 }}
* {{cite journal | vauthors = Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J | title = Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways | journal = J. Biol. Chem. | volume = 281 | issue = 39 | pages = 28802–10 | year = 2006 | pmid = 16893890 | pmc = 1797068 | doi = 10.1074/jbc.M603627200 }}
* {{cite journal | vauthors = Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD | title = Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing | journal = The Journal of Biological Chemistry | volume = 282 | issue = 9 | pages = 6484–93 | date = March 2007 | pmid = 17158878 | doi = 10.1074/jbc.M608336200 }}
* {{cite journal | vauthors = Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD | title = Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing | journal = J. Biol. Chem. | volume = 282 | issue = 9 | pages = 6484–93 | year = 2007 | pmid = 17158878 | doi = 10.1074/jbc.M608336200 }}
* {{cite journal | vauthors = Wojtala R, Tavares IA, Morton PE, Valderrama F, Thomas NSB, Morris JDH. title = PSKs/TAOKs are activated in mitosis and contribute to mitotic cell rounding and spindle positioning | journal = J. Biol. Chem. | volume = 286 | issue = 34 | pages = 30161–70 | year = 2011 | PMID:21705329 | DOI:10.1074/jbc.M111.228320
{{Refend}}
* {{cite journal | vauthors = de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH | title = Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex | journal = Nature Neuroscience | volume = 15 | issue = 7 | pages = 1022–31 | date = June 2012 | pmid = 22683681 | pmc = 4017029 | doi = 10.1038/nn.3141 }}  
 
* {{cite journal | vauthors = Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP and Morris JDH. title = PSKs/TAOKs phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer's disease | journal = J. Biol. Chem. | volume = 288 | issue = 21 | pages = 15418–29 | year = 2013 |  PMID:23585562 | DOI:10.1074/jbc.M112.448183
{{PDB Gallery|geneid=9344}}
* {{cite journal | vauthors = Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JDH.| title = Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells | journal = Molecular Cancer Therapeutics | volume =16 | issue = 11 | pages = 2410–21 | year = 2017| PMID:28830982  DOI:10.1158/1535-7163.MCT-17-0077
 
* {{cite journal | vauthors = Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RK, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F | title = Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling | journal = Molecular Psychiatry | date = February 2018 | pmid = 29467497 | doi = 10.1038/s41380-018-0025-5 }}
 
* {{cite journal | vauthors = Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JD | title = A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies | journal = Acta Neuropathologica Communications | volume = 6 | issue = 1 | pages = 37 | date = May 2018 | pmid = 29730992 | pmc = 5937037 | doi = 10.1186/s40478-018-0539-8 }}
{{Gene-16-stub}}

Revision as of 17:37, 11 October 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.[1][2][3]

Interactions

TAOK2 has been shown to interact with MAP2K6[4] and MAP2K3.[4]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  2. ↑ Hutchison M, Berman KS, Cobb MH (October 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". The Journal of Biological Chemistry. 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
  3. ↑ "Entrez Gene: TAOK2 TAO kinase 2".
  4. ↑ 4.0 4.1 Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.

Further reading

  • Chen Z, Hutchison M, Cobb MH (October 1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". The Journal of Biological Chemistry. 274 (40): 28803–7. doi:10.1074/jbc.274.40.28803. PMID 10497253.
  • Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD (February 2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". The Journal of Biological Chemistry. 275 (6): 4311–22. doi:10.1074/jbc.275.6.4311. PMID 10660600.
  • Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD (May 2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability". The Journal of Biological Chemistry. 278 (20): 18085–91. doi:10.1074/jbc.M213064200. PMID 12639963.
  • Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH (June 2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors". The Journal of Biological Chemistry. 278 (25): 22278–83. doi:10.1074/jbc.M301173200. PMID 12665513.
  • Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ (September 2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID 13679851.
  • Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J (September 2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways". The Journal of Biological Chemistry. 281 (39): 28802–10. doi:10.1074/jbc.M603627200. PMC 1797068. PMID 16893890.
  • Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD (March 2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing". The Journal of Biological Chemistry. 282 (9): 6484–93. doi:10.1074/jbc.M608336200. PMID 17158878.
  • {{cite journal | vauthors = Wojtala R, Tavares IA, Morton PE, Valderrama F, Thomas NSB, Morris JDH. title = PSKs/TAOKs are activated in mitosis and contribute to mitotic cell rounding and spindle positioning | journal = J. Biol. Chem. | volume = 286 | issue = 34 | pages = 30161–70 | year = 2011 | PMID:21705329 | DOI:10.1074/jbc.M111.228320
  • de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH (June 2012). "Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex". Nature Neuroscience. 15 (7): 1022–31. doi:10.1038/nn.3141. PMC 4017029. PMID 22683681.
  • {{cite journal | vauthors = Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, Garg R, Noble W, Killick R, Bodi I, Hanger DP and Morris JDH. title = PSKs/TAOKs phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer's disease | journal = J. Biol. Chem. | volume = 288 | issue = 21 | pages = 15418–29 | year = 2013 | PMID:23585562 | DOI:10.1074/jbc.M112.448183
  • {{cite journal | vauthors = Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, Linardopoulos S, Tutt AN, Morris JDH.| title = Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells | journal = Molecular Cancer Therapeutics | volume =16 | issue = 11 | pages = 2410–21 | year = 2017| PMID:28830982 DOI:10.1158/1535-7163.MCT-17-0077
  • Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, Yuen RK, Schwanke B, Bedürftig B, Henis M, Scharf S, Kraus V, Dörk R, Hellmann J, Lindenmaier Z, Ellegood J, Hartung H, Kwan V, Sedlacik J, Fiehler J, Schweizer M, Lerch JP, Hanganu-Opatz IL, Morellini F, Scherer SW, Singh KK, Calderon de Anda F (February 2018). "Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling". Molecular Psychiatry. doi:10.1038/s41380-018-0025-5. PMID 29467497.
  • Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, Hanger DP, Morris JD (May 2018). "A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies". Acta Neuropathologica Communications. 6 (1): 37. doi:10.1186/s40478-018-0539-8. PMC 5937037. PMID 29730992.
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