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==Interactions==
==Interactions==
DVL2 has been shown to [[Protein-protein interaction|interact]] with [[Zinc finger protein 165]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005|title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[DAB2]]<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H  |date=June 2003|title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> and [[Arrestin beta 1]].<ref name=pmid11742073>{{cite journal |last=Chen |first=W |author2=Hu L A |author3=Semenov M V |author4=Yanagawa S |author5=Kikuchi A |author6=Lefkowitz R J |author7=Miller W E  |date=December 2001|title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=26 |pages=14889–94 |publisher= |location = United States| issn = 0027-8424| pmid = 11742073 |doi = 10.1073/pnas.211572798 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=64954 }}</ref>
DVL2 has been shown to [[Protein-protein interaction|interact]] with [[Zinc finger protein 165]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=October 2005|title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| pmid = 16189514 |doi = 10.1038/nature04209 | bibcode =2005Natur.437.1173R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[DAB2]]<ref name=pmid12805222>{{cite journal |last=Hocevar |first=B A |author2=Mou F |author3=Rennolds J L |author4=Morris S M |author5=Cooper J A |author6=Howe P H  |date=June 2003|title=Regulation of the Wnt signaling pathway by disabled-2 (Dab2) |journal=EMBO J. |volume=22 |issue=12 |pages=3084–94 |publisher= |location = England| issn = 0261-4189| pmid = 12805222 |doi = 10.1093/emboj/cdg286 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=162138 }}</ref> and [[Arrestin beta 1]].<ref name=pmid11742073>{{cite journal |last=Chen |first=W |author2=Hu L A |author3=Semenov M V |author4=Yanagawa S |author5=Kikuchi A |author6=Lefkowitz R J |author7=Miller W E  |date=December 2001|title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=26 |pages=14889–94 |publisher= |location = United States| issn = 0027-8424| pmid = 11742073 |doi = 10.1073/pnas.211572798 | bibcode =2001PNAS...9814889C | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=64954 }}</ref>


==See also==
==See also==
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*{{cite journal  | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | vauthors=Song DH, Sussman DJ, Seldin DC |title=Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23790–7 |year= 2000 |pmid= 10806215 |doi= 10.1074/jbc.M909107199 }}
*{{cite journal  | vauthors=Zhang Y, Neo SY, Han J, Lin SC |title=Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 25008–14 |year= 2000 |pmid= 10829020 |doi= 10.1074/jbc.M002491200 }}
*{{cite journal  | vauthors=Zhang Y, Neo SY, Han J, Lin SC |title=Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 25008–14 |year= 2000 |pmid= 10829020 |doi= 10.1074/jbc.M002491200 }}
*{{cite journal  | vauthors=Chen W, Hu LA, Semenov MV |title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 14889–94 |year= 2002 |pmid= 11742073 |doi= 10.1073/pnas.211572798  | pmc=64954 |display-authors=etal}}
*{{cite journal  | vauthors=Chen W, Hu LA, Semenov MV |title=β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 14889–94 |year= 2002 |pmid= 11742073 |doi= 10.1073/pnas.211572798  | pmc=64954 |display-authors=etal|bibcode=2001PNAS...9814889C }}
*{{cite journal  | vauthors=Habas R, Kato Y, He X |title=Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 |journal=Cell |volume=107 |issue= 7 |pages= 843–54 |year= 2002 |pmid= 11779461 |doi=10.1016/S0092-8674(01)00614-6  }}
*{{cite journal  | vauthors=Habas R, Kato Y, He X |title=Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 |journal=Cell |volume=107 |issue= 7 |pages= 843–54 |year= 2002 |pmid= 11779461 |doi=10.1016/S0092-8674(01)00614-6  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | vauthors=Habas R, Dawid IB, He X |title=Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation |journal=Genes Dev. |volume=17 |issue= 2 |pages= 295–309 |year= 2003 |pmid= 12533515 |doi= 10.1101/gad.1022203  | pmc=195976 }}
*{{cite journal  | vauthors=Habas R, Dawid IB, He X |title=Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation |journal=Genes Dev. |volume=17 |issue= 2 |pages= 295–309 |year= 2003 |pmid= 12533515 |doi= 10.1101/gad.1022203  | pmc=195976 }}
*{{cite journal  | vauthors=Chen W, ten Berge D, Brown J |title=Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 |journal=Science |volume=301 |issue= 5638 |pages= 1391–4 |year= 2003 |pmid= 12958364 |doi= 10.1126/science.1082808 |display-authors=etal}}
*{{cite journal  | vauthors=Chen W, ten Berge D, Brown J |title=Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 |journal=Science |volume=301 |issue= 5638 |pages= 1391–4 |year= 2003 |pmid= 12958364 |doi= 10.1126/science.1082808 |display-authors=etal|bibcode=2003Sci...301.1391C }}
*{{cite journal  | vauthors=Wong CK, Luo W, Deng Y |title=The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39366–73 |year= 2004 |pmid= 15262978 |doi= 10.1074/jbc.M404598200 |display-authors=etal}}
*{{cite journal  | vauthors=Wong CK, Luo W, Deng Y |title=The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39366–73 |year= 2004 |pmid= 15262978 |doi= 10.1074/jbc.M404598200 |display-authors=etal}}
*{{cite journal  | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | vauthors=Torban E, Wang HJ, Groulx N, Gros P |title=Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52703–13 |year= 2005 |pmid= 15456783 |doi= 10.1074/jbc.M408675200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | vauthors=Zhang L, Gao X, Wen J |title=Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation |journal=J. Biol. Chem. |volume=281 |issue= 13 |pages= 8607–12 |year= 2006 |pmid= 16446366 |doi= 10.1074/jbc.M600274200 |display-authors=etal}}
*{{cite journal  | vauthors=Zhang L, Gao X, Wen J |title=Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation |journal=J. Biol. Chem. |volume=281 |issue= 13 |pages= 8607–12 |year= 2006 |pmid= 16446366 |doi= 10.1074/jbc.M600274200 |display-authors=etal}}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}

Latest revision as of 07:31, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (protein)

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Wikidata
View/Edit Human

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[1][2]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[2]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,[3] DAB2[4] and Arrestin beta 1.[5]

See also

References

  1. ↑ Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242.
  2. ↑ 2.0 2.1 "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
  3. ↑ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
  5. ↑ Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. United States. 98 (26): 14889–94. Bibcode:2001PNAS...9814889C. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073.

Further reading



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