KDM6B: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: HTTP→HTTPS)
 
imported>CitationCleanerBot
 
Line 1: Line 1:
{{Underlinked|date=November 2016}}
{{Infobox_gene}}
{{Infobox_gene}}


Line 9: Line 8:
| accessdate = 2016-04-09
| accessdate = 2016-04-09
}}</ref>
}}</ref>
== Regulation during differentation ==
KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.<ref>{{Cite journal|last=Boeckel|first=Jes-Niels|last2=Derlet|first2=Anja|last3=Glaser|first3=Simone F.|last4=Luczak|first4=Annika|last5=Lucas|first5=Tina|last6=Heumüller|first6=Andreas W.|last7=Krüger|first7=Marcus|last8=Zehendner|first8=Christoph M.|last9=Kaluza|first9=David|date=July 2016|title=JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells|journal=Arteriosclerosis, Thrombosis, and Vascular Biology|volume=36|issue=7|pages=1425–1433|doi=10.1161/ATVBAHA.116.307695|issn=1524-4636|pmid=27199445}}</ref>


== Small molecule inhibition ==
== Small molecule inhibition ==
A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.<ref>{{Cite journal|last=Kruidenier|first=Laurens|last2=Chung|first2=Chun-wa|last3=Cheng|first3=Zhongjun|last4=Liddle|first4=John|last5=Che|first5=KaHing|last6=Joberty|first6=Gerard|last7=Bantscheff|first7=Marcus|last8=Bountra|first8=Chas|last9=Bridges|first9=Angela|date=2012-08-16|title=A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response|journal=Nature|volume=488|issue=7411|pages=404–408|doi=10.1038/nature11262|issn=1476-4687|pmc=4691848|pmid=22842901}}</ref>
A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone [[demethylase]] family to modulate [[proinflammatory]] response in [[macrophage]].<ref>{{Cite journal|last=Kruidenier|first=Laurens|last2=Chung|first2=Chun-wa|last3=Cheng|first3=Zhongjun|last4=Liddle|first4=John|last5=Che|first5=KaHing|last6=Joberty|first6=Gerard|last7=Bantscheff|first7=Marcus|last8=Bountra|first8=Chas|last9=Bridges|first9=Angela|date=2012-08-16|title=A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response|journal=Nature|volume=488|issue=7411|pages=404–408|doi=10.1038/nature11262|issn=1476-4687|pmc=4691848|pmid=22842901}}</ref>


== References ==
== References ==

Latest revision as of 14:32, 26 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene. [1]

Regulation during differentation

KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.[2]

Small molecule inhibition

A small molecule inhibition (GSK-J1) has been developed to inhibit jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophage.[3]

References

  1. ↑ "Entrez Gene: Lysine demethylase 6B". Retrieved 2016-04-09.
  2. ↑ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M.; Kaluza, David (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
  3. ↑ Kruidenier, Laurens; Chung, Chun-wa; Cheng, Zhongjun; Liddle, John; Che, KaHing; Joberty, Gerard; Bantscheff, Marcus; Bountra, Chas; Bridges, Angela (2012-08-16). "A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response". Nature. 488 (7411): 404–408. doi:10.1038/nature11262. ISSN 1476-4687. PMC 4691848. PMID 22842901.

Further reading

  • Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K (2007). "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature. 449 (7163): 731–4. doi:10.1038/nature06145. PMID 17713478.


Retrieved from "https://www.wikidoc.org/index.php?title=KDM6B&oldid=1529322"