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{{Infobox_gene}}
{{Infobox_gene}}
'''Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1''', also known as '''UQCRFS1''', is a [[protein]] which in humans is encoded by the ''UQCRFS1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7386| accessdate = }}</ref>
'''Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1''', also known as '''UQCRFS1''', '''Rieske iron-sulfur (Fe-S) protein''', '''Cytochrome b-c1 complex subunit 5''', or '''Complex III subunit 5''' is a [[protein]] which in humans is encoded by the ''UQCRFS1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7386| access-date = }}{{PD-notice}}</ref> UQCRFS1 is a subunit of the respiratory chain protein [[ubiquinol-cytochrome-c reductase|Ubiquinol Cytochrome c Reductase]] (UQCR, [[Complex III]] or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, [[MT-CYB|MTCYTB]] (mitochondrial [[cytochrome b]]) and ten nuclear genes [[UQCRC1]], [[UQCRC2]], [[Cytochrome C1]], '''UQCRFS1''' (this protein, a type of [[Rieske protein]]), [[UQCRB]],{{gene|UQCRQ}} ("11kDa protein"), [[UQCRH]] (cyt c1 Hinge protein), [[UCRC]] ("cyt. c1 associated protein"), and {{gene|UQCR}} ("Rieske-associated protein").<ref name="Uniprot"/>


UQCRFS1 is a subunit of the respiratory chain protein [[ubiquinol-cytochrome-c reductase|Ubiquinol Cytochrome c Reductase]] (UQCR, [[Complex III]] or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene:
== Structure ==
''UQCRFS1'' is located on the [[Locus (genetics)|q arm]] of [[chromosome]] 19 in position 12, has 2 [[exon]]s, and spans 5,969 base pairs.<ref name="entrez" /> The ''UQCRFS1'' gene produces a 29.7 kDa protein composed of 274 [[amino acid]]s.<ref>{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–53 | date = October 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref>{{Cite web |url= https://amino.heartproteome.org/web/protein/P47985 |title=Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) —— Protein Information |last=Yao|first=Daniel | name-list-format = vanc |website=amino.heartproteome.org|access-date=2018-07-27}}</ref> UQCRFS1 is a subunit of the respiratory chain protein [[ubiquinol-cytochrome-c reductase|Ubiquinol Cytochrome c Reductase]] (UQCR, [[Complex III]] or Cytochrome bc1 complex). The structure of the complex is a symmetric homodimer composed of one [[mitochondrial genome]] encoded cytochrome b subunit and ten other nucleus encoded subunits.<ref name = "ref1">{{cite journal | vauthors = Gil Borlado MC, Moreno Lastres D, Gonzalez Hoyuela M, Moran M, Blazquez A, Pello R, Marin Buera L, Gabaldon T, Garcia Peñas JJ, Martín MA, Arenas J, Ugalde C | title = Impact of the mitochondrial genetic background in complex III deficiency | journal = PLOS One | volume = 5 | issue = 9 | date = September 2010 | pmid = 20862300 | doi = 10.1371/journal.pone.0012801 }}</ref> The primary structure of UQCRFS1 from cDNA analysis is composed of a 78 amino acid long [[N-terminal]] extension sequence.<ref>{{cite journal | vauthors = Nishikimi M, Hosokawa Y, Toda H, Suzuki H, Ozawa T | title = The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis | journal = Biochemistry International | volume = 20 | issue = 1 | pages = 155–60 | year = 1990 | pmid = 2158323 | doi =  }}</ref>


* [[MT-CYB|MTCYTB]] (mitochondrial [[cytochrome b]])
== Function ==
The ''UQCRFS1'' gene encodes for an [[iron-sulfur protein]], which is an essential subunit of the [[ubiquinol-cytochrome-c reductase|Ubiquinol Cytochrome c Reductase]] or Complex III in the [[mitochondrial respiratory chain]].<ref>{{cite journal | vauthors = Pennacchio LA, Bergmann A, Fukushima A, Okubo K, Salemi A, Lennon GG | title = Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein | journal = Gene | volume = 155 | issue = 2 | pages = 207–11 | date = April 1995 | pmid = 7721092 }}</ref>
[[ubiquinol-cytochrome-c reductase|Complex III]] is responsible for electron transfer from [[coenzyme Q]] to [[cytochrome c]] as well as the proton transfer from the [[extracellular matrix]] to the [[intermembrane space]] which leads to ATP-coupled [[electrochemical potential]] generation. Incorporation of the subunit UQCRFS1 is the second to last step in [[ubiquinol-cytochrome-c reductase|complex III]] assembly.<ref name = "hello">{{cite journal | vauthors = Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M | title = TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III | journal = Molecular Cell | volume = 67 | issue = 1 | pages = 96–105.e4 | date = July 2017 | pmid = 28673544 | doi = 10.1016/j.molcel.2017.06.001 }}</ref> Once it is incorporated, UQCRFS1 undergoes [[Proteolysis|proteolytic processing]], which is essential for the correct insertion into [[ubiquinol-cytochrome-c reductase|Complex III]]. Preventions of the insertion may occur due to UQCRFS1-derived fragments, leading to a loss of [[ubiquinol-cytochrome-c reductase|Complex III]] structure and function.<ref name="Uniprot">{{cite web|title= UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial|url=https://www.uniprot.org/uniprot/P47985|publisher=The UniProt Consortium}}</ref><ref name = "hello" />


and ten nuclear genes:
==Clinical significance==
The ''UQCRFS1'' gene has been shown to be involved in [[carcinogenesis]] of some cancers. It is mainly associated with more aggressive [[tumors]], and results in the development of more aggressive [[phenotypes]] of [[breast cancer]]s. The association was found with a grade 3 amplification of the UQCRFS1 gene.<ref>{{cite journal | vauthors = Ohashi Y, Kaneko SJ, Cupples TE, Young SR | title = Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples | journal = Gynecologic Oncology | volume = 93 | issue = 1 | pages = 54–8 | date = April 2004 | pmid = 15047214 | doi = 10.1016/j.ygyno.2004.01.019 }}</ref> In addition, [[Acute myeloid leukemia]] (AML) has been found to be associated with the amplification of ''UQCRFS1'' gene.<ref>{{cite journal | vauthors = Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR | title = Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping | journal = Genes, Chromosomes & Cancer | volume = 34 | issue = 1 | pages = 42–7 | date = May 2002 | pmid = 11921281 }}</ref> In contrast, UQCRFS1 and complex III has been absent in renal cell [[carcinoma]], though the mechanism is unknown.<ref>{{cite journal | vauthors = Sarto C, Marocchi A, Sanchez JC, Giannone D, Frutiger S, Golaz O, Wilkins MR, Doro G, Cappellano F, Hughes G, Hochstrasser DF, Mocarelli P | title = Renal cell carcinoma and normal kidney protein expression | journal = Electrophoresis | volume = 18 | issue = 3-4 | pages = 599–604 | date = 1997 | pmid = 9150947 | doi = 10.1002/elps.1150180343 }}</ref>


* [[UQCRC1]], [[UQCRC2]], [[Cytochrome C1]], '''UQCRFS1''' (this protein, a type of [[Rieske protein]]), [[UQCRB]],{{gene|UQCRQ}} ("11kDa protein"), [[UQCRH]] (cyt c1 Hinge protein), [[UCRC]] ("cyt. c1 associated protein"), and {{gene|UQCR}} ("Rieske-associated protein").
== Interactions ==


After processing the cleaved leader sequence of the iron-sulfur protein is retained as subunit 9, giving 11 subunits from 10 genes.
In addition to co-complexes, UQCRFS1 has [[Protein–protein interaction|protein-protein interactions]] with [[UQCRB]], [[BCS1L]], [[COX6B1]], [[UQCRQ]], [[NDUFA9]], and other proteins.<ref>
{{cite journal | vauthors = Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R, Kohler C, Khadake J, Leroy C, Liban A, Lieftink C, Montecchi-Palazzi L, Orchard S, Risse J, Robbe K, Roechert B, Thorneycroft D, Zhang Y, Apweiler R, Hermjakob H | title = IntAct--open source resource for molecular interaction data | journal = Nucleic Acids Research | volume = 35 | issue = Database issue | pages = D561-5 | date = January 2007 | pmid = 17145710 | doi = 10.1093/nar/gkl958 }}</ref>{{clear}}


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shimomura Y, Nishikimi M, Ozawa T | title = Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1 | journal = The Journal of Biological Chemistry | volume = 260 | issue = 28 | pages = 15075–80 | date = December 1985 | pmid = 2999105 | doi =  }}
| citations =
* {{cite journal | vauthors = Duncan AM, Anderson L, Duff C, Ozawa T, Suzuki H, Worton R, Rozen R | title = Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome | journal = Genomics | volume = 21 | issue = 1 | pages = 281–3 | date = May 1994 | pmid = 8088805 | doi = 10.1006/geno.1994.1260 }}
*{{cite journal  |vauthors=Nishikimi M, Hosokawa Y, Toda H, etal |title=The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis. |journal=Biochem. Int. |volume=20 |issue= 1 |pages= 155–60 |year= 1990 |pmid= 2158323 |doi=  }}
* {{cite journal | vauthors = Sarto C, Marocchi A, Sanchez JC, Giannone D, Frutiger S, Golaz O, Wilkins MR, Doro G, Cappellano F, Hughes G, Hochstrasser DF, Mocarelli P | title = Renal cell carcinoma and normal kidney protein expression | journal = Electrophoresis | volume = 18 | issue = 3-4 | pages = 599–604 | year = 1997 | pmid = 9150947 | doi = 10.1002/elps.1150180343 }}
*{{cite journal | vauthors=Shimomura Y, Nishikimi M, Ozawa T |title=Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1. |journal=J. Biol. Chem. |volume=260 |issue= 28 |pages= 15075–80 |year= 1986 |pmid= 2999105 |doi=  }}
* {{cite journal | vauthors = Kaneko SJ, Gerasimova T, Smith ST, Lloyd KO, Suzumori K, Young SR | title = CA125 and UQCRFS1 FISH studies of ovarian carcinoma | journal = Gynecologic Oncology | volume = 90 | issue = 1 | pages = 29–36 | date = July 2003 | pmid = 12821338 | doi = 10.1016/S0090-8258(03)00144-6 }}
*{{cite journal | vauthors=Pennacchio LA, Bergmann A, Fukushima A  | author-link=Len A. Pennacchio  |title=Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein. |journal=Gene |volume=155 |issue= 2 |pages= 207–11 |year= 1995 |pmid= 7721092 |doi=10.1016/0378-1119(94)00683-J  |display-authors=etal}}
* {{cite journal | vauthors = Ohashi Y, Kaneko SJ, Cupples TE, Young SR | title = Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples | journal = Gynecologic Oncology | volume = 93 | issue = 1 | pages = 54–8 | date = April 2004 | pmid = 15047214 | doi = 10.1016/j.ygyno.2004.01.019 }}
*{{cite journal  |vauthors=Duncan AM, Anderson L, Duff C, etal |title=Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome. |journal=Genomics |volume=21 |issue= 1 |pages= 281–3 |year= 1994 |pmid= 8088805 |doi= 10.1006/geno.1994.1260 }}
*{{cite journal   |vauthors=Sarto C, Marocchi A, Sanchez JC, etal |title=Renal cell carcinoma and normal kidney protein expression. |journal=Electrophoresis |volume=18 |issue= 3–4 |pages= 599–604 |year= 1997 |pmid= 9150947 |doi= 10.1002/elps.1150180343 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Kaneko SJ, Gerasimova T, Smith ST, etal |title=CA125 and UQCRFS1 FISH studies of ovarian carcinoma |journal=Gynecol. Oncol. |volume=90 |issue= 1 |pages= 29–36 |year= 2003 |pmid= 12821338 |doi=10.1016/S0090-8258(03)00144-6 }}
*{{cite journal | vauthors=Ohashi Y, Kaneko SJ, Cupples TE, Young SR |title=Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples |journal=Gynecol. Oncol. |volume=93 |issue= 1 |pages= 54–8 |year= 2004 |pmid= 15047214 |doi= 10.1016/j.ygyno.2004.01.019 }}
*{{cite journal  |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19 |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7386}}
{{PDB Gallery|geneid=7386}}


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Latest revision as of 18:18, 4 September 2018

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Orthologs
SpeciesHumanMouse
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Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1, also known as UQCRFS1, Rieske iron-sulfur (Fe-S) protein, Cytochrome b-c1 complex subunit 5, or Complex III subunit 5 is a protein which in humans is encoded by the UQCRFS1 gene.[1] UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes UQCRC1, UQCRC2, Cytochrome C1, UQCRFS1 (this protein, a type of Rieske protein), UQCRB,UQCRQ ("11kDa protein"), UQCRH (cyt c1 Hinge protein), UCRC ("cyt. c1 associated protein"), and UQCR ("Rieske-associated protein").[2]

Structure

UQCRFS1 is located on the q arm of chromosome 19 in position 12, has 2 exons, and spans 5,969 base pairs.[1] The UQCRFS1 gene produces a 29.7 kDa protein composed of 274 amino acids.[3][4] UQCRFS1 is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex). The structure of the complex is a symmetric homodimer composed of one mitochondrial genome encoded cytochrome b subunit and ten other nucleus encoded subunits.[5] The primary structure of UQCRFS1 from cDNA analysis is composed of a 78 amino acid long N-terminal extension sequence.[6]

Function

The UQCRFS1 gene encodes for an iron-sulfur protein, which is an essential subunit of the Ubiquinol Cytochrome c Reductase or Complex III in the mitochondrial respiratory chain.[7] Complex III is responsible for electron transfer from coenzyme Q to cytochrome c as well as the proton transfer from the extracellular matrix to the intermembrane space which leads to ATP-coupled electrochemical potential generation. Incorporation of the subunit UQCRFS1 is the second to last step in complex III assembly.[8] Once it is incorporated, UQCRFS1 undergoes proteolytic processing, which is essential for the correct insertion into Complex III. Preventions of the insertion may occur due to UQCRFS1-derived fragments, leading to a loss of Complex III structure and function.[2][8]

Clinical significance

The UQCRFS1 gene has been shown to be involved in carcinogenesis of some cancers. It is mainly associated with more aggressive tumors, and results in the development of more aggressive phenotypes of breast cancers. The association was found with a grade 3 amplification of the UQCRFS1 gene.[9] In addition, Acute myeloid leukemia (AML) has been found to be associated with the amplification of UQCRFS1 gene.[10] In contrast, UQCRFS1 and complex III has been absent in renal cell carcinoma, though the mechanism is unknown.[11]

Interactions

In addition to co-complexes, UQCRFS1 has protein-protein interactions with UQCRB, BCS1L, COX6B1, UQCRQ, NDUFA9, and other proteins.[12]

References

  1. ↑ 1.0 1.1 "Entrez Gene: UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1". This article incorporates text from this source, which is in the public domain.
  2. ↑ 2.0 2.1 "UQCRFS1 - Cytochrome b-c1 complex subunit Rieske, mitochondrial". The UniProt Consortium.
  3. ↑ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  4. ↑ Yao D. "Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) —— Protein Information". amino.heartproteome.org. Retrieved 2018-07-27.
  5. ↑ Gil Borlado MC, Moreno Lastres D, Gonzalez Hoyuela M, Moran M, Blazquez A, Pello R, Marin Buera L, Gabaldon T, Garcia Peñas JJ, Martín MA, Arenas J, Ugalde C (September 2010). "Impact of the mitochondrial genetic background in complex III deficiency". PLOS One. 5 (9). doi:10.1371/journal.pone.0012801. PMID 20862300.
  6. ↑ Nishikimi M, Hosokawa Y, Toda H, Suzuki H, Ozawa T (1990). "The primary structure of human Rieske iron-sulfur protein of mitochondrial cytochrome bc1 complex deduced from cDNA analysis". Biochemistry International. 20 (1): 155–60. PMID 2158323.
  7. ↑ Pennacchio LA, Bergmann A, Fukushima A, Okubo K, Salemi A, Lennon GG (April 1995). "Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein". Gene. 155 (2): 207–11. PMID 7721092.
  8. ↑ 8.0 8.1 Bottani E, Cerutti R, Harbour ME, Ravaglia S, Dogan SA, Giordano C, Fearnley IM, D'Amati G, Viscomi C, Fernandez-Vizarra E, Zeviani M (July 2017). "TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III". Molecular Cell. 67 (1): 96–105.e4. doi:10.1016/j.molcel.2017.06.001. PMID 28673544.
  9. ↑ Ohashi Y, Kaneko SJ, Cupples TE, Young SR (April 2004). "Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples". Gynecologic Oncology. 93 (1): 54–8. doi:10.1016/j.ygyno.2004.01.019. PMID 15047214.
  10. ↑ Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR (May 2002). "Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping". Genes, Chromosomes & Cancer. 34 (1): 42–7. PMID 11921281.
  11. ↑ Sarto C, Marocchi A, Sanchez JC, Giannone D, Frutiger S, Golaz O, Wilkins MR, Doro G, Cappellano F, Hughes G, Hochstrasser DF, Mocarelli P (1997). "Renal cell carcinoma and normal kidney protein expression". Electrophoresis. 18 (3–4): 599–604. doi:10.1002/elps.1150180343. PMID 9150947.
  12. ↑ Kerrien S, Alam-Faruque Y, Aranda B, Bancarz I, Bridge A, Derow C, Dimmer E, Feuermann M, Friedrichsen A, Huntley R, Kohler C, Khadake J, Leroy C, Liban A, Lieftink C, Montecchi-Palazzi L, Orchard S, Risse J, Robbe K, Roechert B, Thorneycroft D, Zhang Y, Apweiler R, Hermjakob H (January 2007). "IntAct--open source resource for molecular interaction data". Nucleic Acids Research. 35 (Database issue): D561–5. doi:10.1093/nar/gkl958. PMID 17145710.

Further reading

  • Shimomura Y, Nishikimi M, Ozawa T (December 1985). "Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1". The Journal of Biological Chemistry. 260 (28): 15075–80. PMID 2999105.
  • Duncan AM, Anderson L, Duff C, Ozawa T, Suzuki H, Worton R, Rozen R (May 1994). "Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein subunit of the mitochondrial cytochrome bc1 complex to the 22q13 and 19q12-q13.1 regions of the human genome". Genomics. 21 (1): 281–3. doi:10.1006/geno.1994.1260. PMID 8088805.
  • Sarto C, Marocchi A, Sanchez JC, Giannone D, Frutiger S, Golaz O, Wilkins MR, Doro G, Cappellano F, Hughes G, Hochstrasser DF, Mocarelli P (1997). "Renal cell carcinoma and normal kidney protein expression". Electrophoresis. 18 (3–4): 599–604. doi:10.1002/elps.1150180343. PMID 9150947.
  • Kaneko SJ, Gerasimova T, Smith ST, Lloyd KO, Suzumori K, Young SR (July 2003). "CA125 and UQCRFS1 FISH studies of ovarian carcinoma". Gynecologic Oncology. 90 (1): 29–36. doi:10.1016/S0090-8258(03)00144-6. PMID 12821338.
  • Ohashi Y, Kaneko SJ, Cupples TE, Young SR (April 2004). "Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples". Gynecologic Oncology. 93 (1): 54–8. doi:10.1016/j.ygyno.2004.01.019. PMID 15047214.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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