SLA2: Difference between revisions
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'''Src-like-adapter 2''' is a [[protein]] that in humans is encoded by the ''SLA2'' [[gene]].<ref name="pmid11696592">{{cite journal | vauthors = Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J | title = Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling | journal = J Exp Med | volume = 194 | issue = 9 | pages = 1263–76 | date = Nov 2001 | pmid = 11696592 | pmc = 2195979 | doi = 10.1084/jem.194.9.1263 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLA2 Src-like-adaptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84174| accessdate = }}</ref> | '''Src-like-adapter 2''' is a [[protein]] that in humans is encoded by the ''SLA2'' [[gene]].<ref name="pmid11696592">{{cite journal | vauthors = Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J | title = Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling | journal = J Exp Med | volume = 194 | issue = 9 | pages = 1263–76 | date = Nov 2001 | pmid = 11696592 | pmc = 2195979 | doi = 10.1084/jem.194.9.1263 | url = http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.283.1429&rep=rep1&type=pdf }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLA2 Src-like-adaptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84174| accessdate = }}</ref> | ||
== Function == | == Function == | ||
Revision as of 14:18, 4 November 2018
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Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[1][2]
Function
This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]
Interactions
SLA2 has been shown to interact with Cbl gene.[3]
References
- ↑ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med. 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592.
- ↑ 2.0 2.1 "Entrez Gene: SLA2 Src-like-adaptor 2".
- ↑ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.
Further reading
- Loreto MP, McGlade CJ (2003). "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v". Oncogene. 22 (2): 266–73. doi:10.1038/sj.onc.1206114. PMID 12527895.
- Loreto MP, Berry DM, McGlade CJ (2002). "Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling". Mol. Cell. Biol. 22 (12): 4241–55. doi:10.1128/MCB.22.12.4241-4255.2002. PMC 133880. PMID 12024036.
- Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O, Sawasdikosol S, Lodish HF, Mann M (2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219.
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