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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the [[apolipoprotein]] L [[gene family]]. The encoded protein is found in the [[cytoplasm]], where it may affect the movement of [[lipid]]s or allow the [[Molecular binding|binding]] of lipids to [[organelle]]s. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez" />
| summary_text = This gene is a member of the [[apolipoprotein]] L [[gene family]] and [[protein]] in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp.  Localization of this protein is mainly found in the [[cytosol]], [[nucleoplasm]] and additionally, it is also seen in the [[Nuclear bodies]].<ref name="Protein Location">{{cite web | title = The Human Protein atlas Gene: APOL2 apolipoprotein L, 2| url = https://www.proteinatlas.org/ENSG00000128335-APOL2/tissue#gene_information | accessdate = }}</ref>  The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez" />
}}
}}
== Protein Sequence ==
>sp|Q9BQE5|1-337
MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLA
SHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVS
NSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQ
ARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYA
PPPHIIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLE
GAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ
== Interactions ==
APOL2 has been shown to [[Protein-protein interaction|interact]] with:
* [[IFN-γ]],<ref name = pmid20665705 >{{cite journal | vauthors = Liao W, Goh FY, Betts RJ, Kemeny DM, Tam J, Bay BH, Wong WS | title = A novel anti-apoptotic role for apolipoprotein L2 in IFN-gamma-induced cytotoxicity in human bronchial epithelial cells | journal = J Cell Physiol | volume = 226 | issue = 2 | pages = 397–406| date =February 2011 | pmid = 10023675 | doi = 10.1002/jcp.22345 }}</ref>
* [[CD81]],<ref name = pmid30024968 >{{cite journal | vauthors = Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C,  Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G | title = Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB | journal = PLOS Pathogens | volume = 14 | issue = 7 | pages = 55–67| date =July 2018 | pmid = 12150997 | doi = 10.1371/journal.ppat.1007111 }}</ref>
* [[TNF-α]],<ref name = pmid19299565>{{cite journal | vauthors = Smith EE, Malik HS | title = The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions | journal = Genome Res.  | volume = 19 | issue = 5 | pages = 850–8| date =May 2009 | pmid = 19299565 | pmc = 2675973 | doi = 10.1101/gr.085647.108 }}</ref>
* [[Bcl-2]],<ref name = pmid15671246 >{{cite journal | vauthors = Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA | title = Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells | journal = . J Cell Physiol | volume = 3 | issue = 1 | pages = 21–31| date =January 2005 | pmid = 11526476 | doi = 10.1038/sj.onc.1204529 }}</ref>
== Splice Variants ==
ApoL2 has 5 splice variants,<ref name="Protein Information">{{cite web | title = The Human Protein atlas Gene: APOL2 apolipoprotein L, 2| url = https://www.proteinatlas.org/ENSG00000128335-APOL2/tissue#gene_information | accessdate = }}</ref> ,
*APOL2-001
This transcript has got 6 exons, 12 domains and features are annotated, 263 variations are related this and maps to 35 oligo probes.
*APOL2-002
This transcript has got 5 exons,  12 domains and features are annotated, 263 variations are related with this gene and maps to 37 oligo probes.
*APOL2-006
This transcript has got 6 exons, is annotated with 3 domains and features, 62 variations are related with this gene and maps to 20 oligo probes.
*APOL2-008
This transcript has got 6 exons, 12 domains and features are annotated, 331 variations are related with this gene and maps to 32 oligo probes.
*APOL2-009
This transcript has got 5 exons, 4 domains and features are annotated, 104 variations are related with this gene and maps to 13 oligo probes.
== Functions of the ApoL2 ==
*Acute Inflammation Response <ref name = pmid20702412 >{{cite journal | vauthors = Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM, Nosrat CA | title = Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma| journal = J Biol Chem | volume = 285 | issue = 42 | pages = 32512–21 | date = October 2010 | pmid = 20702412 | pmc = 2952253| doi = 10.1074/jbc.M110.150490 }}</ref><ref name = pmid23856606 >{{cite journal | vauthors = Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA | title = Mitochondrial proteomic analysis of human host cells infected with H3N2 swine influenza virus| journal = J Proteomics| volume = 8 | issue = 91 | pages =  136–50| date =October 2013 | pmid = 23856606 | doi = 10.1016/j.jprot.2013.06.037 }}</ref>
* Cholesterol Metabolic Process<ref name = pmid22303337 >{{cite journal | vauthors = Wang K, Edmondson AC, Li M, Gao F, Qasim AN, Devaney JM, Burnett MS, Waterworth DM, Mooser V, Grant SF, Epstein SE, Reilly MP, Hakonarson H, Rader DJ | title = Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation | journal = Frontiers in Genetics | volume = 2 | issue = 4 | pages = 41| date = July 2011 | pmid = 22303337 | pmc = 3268595 | doi = 10.3389/fgene.2011.00041}}</ref>
*Lipid Metabolic Process<ref name = pmid15671246 >{{cite journal | vauthors = Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA | title = Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells | journal = . J Cell Physiol | volume = 3 | issue = 1 | pages = 21–31| date =January 2005 | pmid = 11526476 | doi = 10.1038/sj.onc.1204529 }}</ref>
*Maternal Process Involved in Female Pregnancy<ref name = pmid20008415 >{{cite journal | vauthors = Brosens JJ, Hodgetts A, Feroze-Zaidi F, Sherwin JR, Fusi L, Salker MS, Higham J, Rose GL, Kajihara T, Young SL, Lessey BA, Henriet P, Langford PR, Fazleabas AT | title = Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis | journal = MHR: Basic Science of Reproductive Medicine | volume = 16 | issue = 4 | pages = 273–285| date =April 2010 | pmid = 20008415 | pmc = 2834406 | doi = 10.1093/molehr/gap108 }}</ref>
* Lipid binding<ref name="Go Biological Process">{{cite web | title = Nextprot Gene: APOL2 apolipoprotein L, 2| url = https://www.nextprot.org/entry/NX_Q9BQE5/ | accessdate = }}</ref>
* Signalling Receptor Binding<ref name="Go Biological Process">{{cite web | title = Nextprot Gene: APOL2 apolipoprotein L, 2| url = https://www.nextprot.org/entry/NX_Q9BQE5/ | accessdate = }}</ref>
{{Div col end}}
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==References==
==References==

Revision as of 12:56, 27 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.[1][2][3]

This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found in the cytosol, nucleoplasm and additionally, it is also seen in the Nuclear bodies.[4] The involvement of this gene may affect in the movement of lipids and binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.[3]


Protein Sequence

>sp|Q9BQE5|1-337

MNPESSIFIEDYLKYFQDQVSRENLLQLLTDDEAWNGFVAAAELPRDEADELRKALNKLA

SHMVMKDKNRHDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEEVEQVHRGTTIANVVS

NSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQ

ARNLDQSGTNVAKVMKEFVGGNTPNVLTLVDNWYQVTQGIGRNIRAIRRARANPQLGAYA

PPPHIIGRISAEGGEQVERVVEGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLE

GAKSESAEELKKRAQELEGKLNFLTKIHEMLQPGQDQ

Interactions

APOL2 has been shown to interact with:

Splice Variants

ApoL2 has 5 splice variants,[9] ,

  • APOL2-001

This transcript has got 6 exons, 12 domains and features are annotated, 263 variations are related this and maps to 35 oligo probes.

  • APOL2-002

This transcript has got 5 exons, 12 domains and features are annotated, 263 variations are related with this gene and maps to 37 oligo probes.

  • APOL2-006

This transcript has got 6 exons, is annotated with 3 domains and features, 62 variations are related with this gene and maps to 20 oligo probes.

  • APOL2-008

This transcript has got 6 exons, 12 domains and features are annotated, 331 variations are related with this gene and maps to 32 oligo probes.

  • APOL2-009

This transcript has got 5 exons, 4 domains and features are annotated, 104 variations are related with this gene and maps to 13 oligo probes.

Functions of the ApoL2

  • Acute Inflammation Response [10][11]
  • Cholesterol Metabolic Process[12]
  • Lipid Metabolic Process[8]
  • Maternal Process Involved in Female Pregnancy[13]
  • Lipid binding[14]
  • Signalling Receptor Binding[14]

References

  1. ↑ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  2. ↑ Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
  3. ↑ 3.0 3.1 "Entrez Gene: APOL2 apolipoprotein L, 2".
  4. ↑ "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2".
  5. ↑ Liao W, Goh FY, Betts RJ, Kemeny DM, Tam J, Bay BH, Wong WS (February 2011). "A novel anti-apoptotic role for apolipoprotein L2 in IFN-gamma-induced cytotoxicity in human bronchial epithelial cells". J Cell Physiol. 226 (2): 397–406. doi:10.1002/jcp.22345. PMID 10023675.
  6. ↑ Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C, Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G (July 2018). "Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB". PLOS Pathogens. 14 (7): 55–67. doi:10.1371/journal.ppat.1007111. PMID 12150997.
  7. ↑ Smith EE, Malik HS (May 2009). "The apolipoprotein L family of programmed cell death and immunity genes rapidly evolved in primates at discrete sites of host-pathogen interactions". Genome Res. 19 (5): 850–8. doi:10.1101/gr.085647.108. PMC 2675973. PMID 19299565.
  8. ↑ 8.0 8.1 Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (January 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells". . J Cell Physiol. 3 (1): 21–31. doi:10.1038/sj.onc.1204529. PMID 11526476.
  9. ↑ "The Human Protein atlas Gene: APOL2 apolipoprotein L, 2".
  10. ↑ Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM, Nosrat CA (October 2010). "Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma". J Biol Chem. 285 (42): 32512–21. doi:10.1074/jbc.M110.150490. PMC 2952253. PMID 20702412.
  11. ↑ Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (October 2013). "Mitochondrial proteomic analysis of human host cells infected with H3N2 swine influenza virus". J Proteomics. 8 (91): 136–50. doi:10.1016/j.jprot.2013.06.037. PMID 23856606.
  12. ↑ Wang K, Edmondson AC, Li M, Gao F, Qasim AN, Devaney JM, Burnett MS, Waterworth DM, Mooser V, Grant SF, Epstein SE, Reilly MP, Hakonarson H, Rader DJ (July 2011). "Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation". Frontiers in Genetics. 2 (4): 41. doi:10.3389/fgene.2011.00041. PMC 3268595. PMID 22303337.
  13. ↑ Brosens JJ, Hodgetts A, Feroze-Zaidi F, Sherwin JR, Fusi L, Salker MS, Higham J, Rose GL, Kajihara T, Young SL, Lessey BA, Henriet P, Langford PR, Fazleabas AT (April 2010). "Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis". MHR: Basic Science of Reproductive Medicine. 16 (4): 273–285. doi:10.1093/molehr/gap108. PMC 2834406. PMID 20008415.
  14. ↑ 14.0 14.1 "Nextprot Gene: APOL2 apolipoprotein L, 2".

External links

Further reading



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