| In molecular biology, '''DiGeorge syndrome critical region gene 5 (non-protein coding)''', also known as '''DGCR5''', is a [[long non-coding RNA]]. In humans, it is located on [[Chromosome 22 (human)|chromosome 22q11]], at the ADU breakpoint associated with [[DiGeorge syndrome]].<ref name="pmid8659529">{{cite journal | vauthors = Sutherland HF, Wadey R, McKie JM, Taylor C, Atif U, Johnstone KA, Halford S, Kim UJ, Goodship J, Baldini A, Scambler PJ | title = Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome | journal = American Journal of Human Genetics | volume = 59 | issue = 1 | pages = 23–31 | date = Jul 1996 | pmid = 8659529 | pmc = 1915101 }}</ref> Its expression is regulated by the [[transcription factor]] [[REST (gene)|REST]] (RE1-Silencing Transcription factor).<ref name="pmid19050060">{{cite journal | vauthors = Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L | title = Regulation of neural macroRNAs by the transcriptional repressor REST | journal = Rna | volume = 15 | issue = 1 | pages = 85–96 | date = Jan 2009 | pmid = 19050060 | pmc = 2612765 | doi = 10.1261/rna.1127009 }}</ref> | | In molecular biology, '''DiGeorge syndrome critical region gene 5 (non-protein coding)''', also known as '''DGCR5''', is a [[long non-coding RNA]]. In humans, it is located on [[Chromosome 22 (human)|chromosome 22q11]], at the ADU breakpoint associated with [[DiGeorge syndrome]].<ref name="pmid8659529">{{cite journal | vauthors = Sutherland HF, Wadey R, McKie JM, Taylor C, Atif U, Johnstone KA, Halford S, Kim UJ, Goodship J, Baldini A, Scambler PJ | title = Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome | journal = American Journal of Human Genetics | volume = 59 | issue = 1 | pages = 23–31 | date = Jul 1996 | pmid = 8659529 | pmc = 1915101 }}</ref> Its expression is regulated by the [[transcription factor]] [[REST (gene)|REST]] (RE1-Silencing Transcription factor).<ref name="pmid19050060">{{cite journal | vauthors = Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L | title = Regulation of neural macroRNAs by the transcriptional repressor REST | journal = RNA | volume = 15 | issue = 1 | pages = 85–96 | date = Jan 2009 | pmid = 19050060 | pmc = 2612765 | doi = 10.1261/rna.1127009 }}</ref> |