HNRPH1: Difference between revisions

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{{Infobox_gene}}
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'''Heterogeneous nuclear ribonucleoprotein H''' is a [[protein]] that in humans is encoded by the ''HNRNPH1'' [[gene]].<ref name="pmid7499401">{{cite journal |vauthors=Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE | title = Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes | journal = J Biol Chem | volume = 270 | issue = 48 | pages = 28780–9 |date=Jan 1996 | pmid = 7499401 | pmc =  | doi =10.1074/jbc.270.48.28780  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3187| accessdate = }}</ref>
'''Heterogeneous nuclear ribonucleoprotein H''' is a [[protein]] <ref>{{Cite journal|last=Penumutchu|first=Srinivasa|last2=Chiu|first2=Liang-Yuan|last3=Meagher|first3=Jennifer L.|last4=Hansen|first4=Alexandar L.|last5=Stuckey|first5=Jeanne A.|last6=Tolbert|first6=Blanton S.|date=2018-08-18|title=Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H|journal=Journal of the American Chemical Society|volume=140|issue=37|pages=11661–11673|language=en|doi=10.1021/jacs.8b05366|pmid=30122033|issn=0002-7863}}</ref> that in humans is encoded by the ''HNRNPH1'' [[gene]].<ref name="pmid7499401">{{cite journal |vauthors=Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE | title = Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes | journal = J Biol Chem | volume = 270 | issue = 48 | pages = 28780–9 |date=Jan 1996 | pmid = 7499401 | pmc =  | doi =10.1074/jbc.270.48.28780  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3187| accessdate = }}</ref>


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Latest revision as of 17:55, 21 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein H is a protein [1] that in humans is encoded by the HNRNPH1 gene.[2][3]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. It is very similar to the family member HNRPF. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[3]

References

  1. Penumutchu, Srinivasa; Chiu, Liang-Yuan; Meagher, Jennifer L.; Hansen, Alexandar L.; Stuckey, Jeanne A.; Tolbert, Blanton S. (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMID 30122033.
  2. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
  3. 3.0 3.1 "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

Further reading