UPP1: Difference between revisions
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'''Uridine phosphorylase 1''' is an [[enzyme]] that in humans is encoded by the ''UPP1'' [[gene]].<ref name="pmid752472">{{cite journal |vauthors=Denney RM, Nichols EA, Ruddle FH | title = Assignment of a gene for uridine phosphorylase to chromosome 7 | journal = Cytogenet Cell Genet | volume = 22 | issue = 1–6 | pages = 195–9 |date=September 1979 | pmid = 752472 | pmc = | doi =10.1159/000130934 }}</ref><ref name="pmid11807789">{{cite journal |vauthors=Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T | title = Expression of uridine and thymidine phosphorylase genes in human breast carcinoma | journal = Int J Cancer | volume = 97 | issue = 5 | pages = 631–5 |date=January 2002 | pmid = 11807789 | pmc = | doi =10.1002/ijc.10105 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPP1 uridine phosphorylase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7378| accessdate = }}</ref> | '''Uridine phosphorylase 1''' is an [[enzyme]] that in humans is encoded by the ''UPP1'' [[gene]].<ref name="pmid752472">{{cite journal |vauthors=Denney RM, Nichols EA, Ruddle FH | title = Assignment of a gene for uridine phosphorylase to chromosome 7 | journal = Cytogenet Cell Genet | volume = 22 | issue = 1–6 | pages = 195–9 |date=September 1979 | pmid = 752472 | pmc = | doi =10.1159/000130934 }}</ref><ref name="pmid11807789">{{cite journal |vauthors=Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T | title = Expression of uridine and thymidine phosphorylase genes in human breast carcinoma | journal = Int J Cancer | volume = 97 | issue = 5 | pages = 631–5 |date=January 2002 | pmid = 11807789 | pmc = | doi =10.1002/ijc.10105 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UPP1 uridine phosphorylase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7378| accessdate = }}</ref> | ||
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==Interactions== | ==Interactions== | ||
UPP1 has been shown to [[Protein-protein interaction|interact]] with [[Vimentin]].<ref name=pmid11278417>{{cite journal |last=Russell |first=R L |authorlink= |author2=Cao D |author3=Zhang D |author4=Handschumacher R E |author5=Pizzorno G |date=April 2001 |title=Uridine phosphorylase association with vimentin. Intracellular distribution and localization |journal=J. Biol. Chem. |volume=276 |issue=16 |pages=13302–7 |publisher= |location = United States| issn = 0021-9258| pmid = 11278417 |doi = 10.1074/jbc.M008512200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | UPP1 has been shown to [[Protein-protein interaction|interact]] with [[Vimentin]].<ref name=pmid11278417>{{cite journal |last=Russell |first=R L |authorlink= |author2=Cao D |author3=Zhang D |author4=Handschumacher R E |author5=Pizzorno G |date=April 2001 |title=Uridine phosphorylase association with vimentin. Intracellular distribution and localization |journal=J. Biol. Chem. |volume=276 |issue=16 |pages=13302–7 |publisher= |location = United States| issn = 0021-9258| pmid = 11278417 |doi = 10.1074/jbc.M008512200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | ||
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*{{cite journal |vauthors=Russell RL, Cao D, Zhang D, etal |title=Uridine phosphorylase association with vimentin. Intracellular distribution and localization |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13302–7 |year= 2001 |pmid= 11278417 |doi= 10.1074/jbc.M008512200 }} | *{{cite journal |vauthors=Russell RL, Cao D, Zhang D, etal |title=Uridine phosphorylase association with vimentin. Intracellular distribution and localization |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13302–7 |year= 2001 |pmid= 11278417 |doi= 10.1074/jbc.M008512200 }} | ||
*{{cite journal |vauthors=Miyashita H, Takebayashi Y, Eliason JF, etal |title=Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma |journal=Cancer |volume=94 |issue= 11 |pages= 2959–66 |year= 2002 |pmid= 12115385 |doi= 10.1002/cncr.10568 }} | *{{cite journal |vauthors=Miyashita H, Takebayashi Y, Eliason JF, etal |title=Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma |journal=Cancer |volume=94 |issue= 11 |pages= 2959–66 |year= 2002 |pmid= 12115385 |doi= 10.1002/cncr.10568 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
Latest revision as of 02:31, 19 November 2018
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Uridine phosphorylase 1 is an enzyme that in humans is encoded by the UPP1 gene.[1][2][3]
Interactions
UPP1 has been shown to interact with Vimentin.[4]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Fluorouracil (5-FU) Activity edit
- ↑ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
References
- ↑ Denney RM, Nichols EA, Ruddle FH (September 1979). "Assignment of a gene for uridine phosphorylase to chromosome 7". Cytogenet Cell Genet. 22 (1–6): 195–9. doi:10.1159/000130934. PMID 752472.
- ↑ Kanzaki A, Takebayashi Y, Bando H, Eliason JF, Watanabe Si S, Miyashita H, Fukumoto M, Toi M, Uchida T (January 2002). "Expression of uridine and thymidine phosphorylase genes in human breast carcinoma". Int J Cancer. 97 (5): 631–5. doi:10.1002/ijc.10105. PMID 11807789.
- ↑ "Entrez Gene: UPP1 uridine phosphorylase 1".
- ↑ Russell, R L; Cao D; Zhang D; Handschumacher R E; Pizzorno G (April 2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. United States. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. ISSN 0021-9258. PMID 11278417.
Further reading
- Pizzorno G, Cao D, Leffert JJ, et al. (2002). "Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update". Biochim. Biophys. Acta. 1587 (2–3): 133–44. doi:10.1016/s0925-4439(02)00076-5. PMID 12084455.
- Watanabe S, Uchida T (1995). "Cloning and expression of human uridine phosphorylase". Biochem. Biophys. Res. Commun. 216 (1): 265–72. doi:10.1006/bbrc.1995.2619. PMID 7488099.
- Russell RL, Cao D, Zhang D, et al. (2001). "Uridine phosphorylase association with vimentin. Intracellular distribution and localization". J. Biol. Chem. 276 (16): 13302–7. doi:10.1074/jbc.M008512200. PMID 11278417.
- Miyashita H, Takebayashi Y, Eliason JF, et al. (2002). "Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma". Cancer. 94 (11): 2959–66. doi:10.1002/cncr.10568. PMID 12115385.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Temmink OH, de Bruin M, Laan AC, et al. (2006). "The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells". Int. J. Biochem. Cell Biol. 38 (10): 1759–65. doi:10.1016/j.biocel.2006.04.007. PMID 16798057.
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