PDE7A: Difference between revisions

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'''High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A''' is an [[enzyme]] that in humans is encoded by the ''PDE7A'' [[gene]].<ref name="pmid8389765">{{cite journal | vauthors = Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M | title = Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae | journal = J Biol Chem | volume = 268 | issue = 17 | pages = 12925–32 | date = Jul 1993 | pmid = 8389765 | pmc =  | doi = }}</ref><ref name="pmid9521885">{{cite journal | vauthors = Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T | title = Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13 | journal = Genomics | volume = 48 | issue = 2 | pages = 275–6 | date = Jun 1998 | pmid = 9521885 | pmc =  | doi = 10.1006/geno.1997.5168 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE7A phosphodiesterase 7A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5150| accessdate = }}</ref> Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families.  PDE7A is one of two genes in the PDE7 family, the other being [[PDE7B]]. The PDE7 family, along with the PDE4 and PDE8 families, are are [[cAMP]]-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate ([[cGMP]]).
'''High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A''' is an [[enzyme]] that in humans is encoded by the ''PDE7A'' [[gene]].<ref name="pmid8389765">{{cite journal | vauthors = Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M | title = Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae | journal = J Biol Chem | volume = 268 | issue = 17 | pages = 12925–32 | date = Jul 1993 | pmid = 8389765 | pmc =  | doi = }}</ref><ref name="pmid9521885">{{cite journal | vauthors = Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T | title = Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13 | journal = Genomics | volume = 48 | issue = 2 | pages = 275–6 | date = Jun 1998 | pmid = 9521885 | pmc =  | doi = 10.1006/geno.1997.5168 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PDE7A phosphodiesterase 7A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5150| accessdate = }}</ref> [[Mammal|Mammals]] possess 21 cyclic nucleotide [[phosphodiesterase]] (PDE) genes that are pharmacologically grouped into 11 families.  PDE7A is one of two genes in the [[PDE7]] family, the other being [[PDE7B]]. The PDE7 family, along with the [[PDE4]] and [[PDE8]] families, are [[Cyclic adenosine monophosphate|cAMP]]-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate ([[Cyclic guanosine monophosphate|cGMP]]).


== References ==
== References ==

Revision as of 21:13, 5 March 2018

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A is an enzyme that in humans is encoded by the PDE7A gene.[1][2][3] Mammals possess 21 cyclic nucleotide phosphodiesterase (PDE) genes that are pharmacologically grouped into 11 families. PDE7A is one of two genes in the PDE7 family, the other being PDE7B. The PDE7 family, along with the PDE4 and PDE8 families, are cAMP-specific, showing little to no activity against 3', 5'-cyclic guanosine monophosphate (cGMP).

References

  1. ↑ Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M (Jul 1993). "Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae". J Biol Chem. 268 (17): 12925–32. PMID 8389765.
  2. ↑ Han P, Fletcher CF, Copeland NG, Jenkins NA, Yaremko LM, Michaeli T (Jun 1998). "Assignment of the mouse Pde7A gene to the proximal region of chromosome 3 and of the human PDE7A gene to chromosome 8q13". Genomics. 48 (2): 275–6. doi:10.1006/geno.1997.5168. PMID 9521885.
  3. ↑ "Entrez Gene: PDE7A phosphodiesterase 7A".

Further reading


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