DEFB104A: Difference between revisions

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{{Underlinked|date=May 2016}}
{{Infobox_gene}}
'''Beta-defensin 104''' is a [[protein]] that in [[Human|humans]] is encoded by the ''DEFB104A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB104A defensin, beta 104A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140596| accessdate = }}</ref>


{{Infobox_gene}}
== Function ==
'''Beta-defensin 104''' is a [[protein]] that in humans is encoded by the ''DEFB104A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DEFB104A defensin, beta 104A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140596| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Defensins]] form a family of microbicidal and cytotoxic [[peptides]] made by [[neutrophils]]. Defensins are short, processed peptide [[Molecule|molecules]] that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five [[Synteny|syntenic]] [[Chromosome regions|chromosomal regions]]. [[Chromosome_8_(human)|Chromosome 8p23]] contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more [[Centromere|centromeric]] copy.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.<ref name="entrez" />
}}


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Patil AA, Cai Y, Sang Y, Blecha F, Zhang G | title = Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract | journal = Physiological Genomics | volume = 23 | issue = 1 | pages = 5–17 | date = September 2005 | pmid = 16033865 | doi = 10.1152/physiolgenomics.00104.2005 }}
| citations =
* {{cite journal | vauthors = Vankeerberghen A, Scudiero O, De Boeck K, Macek M, Pignatti PF, Van Hul N, Nuytten H, Salvatore F, Castaldo G, Zemkova D, Vavrova V, Cassiman JJ, Cuppens H | title = Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations | journal = Genomics | volume = 85 | issue = 5 | pages = 574–81 | date = May 2005 | pmid = 15820309 | doi = 10.1016/j.ygeno.2005.02.003 }}
*{{cite journal | vauthors=Patil AA, Cai Y, Sang Y |title=Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. |journal=Physiol. Genomics |volume=23 |issue= 1 |pages= 5–17 |year= 2006 |pmid= 16033865 |doi= 10.1152/physiolgenomics.00104.2005 |display-authors=etal}}
* {{cite journal | vauthors = Boniotto M, Ventura M, Eskdale J, Crovella S, Gallagher G | title = Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution | journal = Genetic Testing | volume = 8 | issue = 3 | pages = 325–7 | year = 2005 | pmid = 15727258 | doi = 10.1089/gte.2004.8.325 }}
*{{cite journal | vauthors=Vankeerberghen A, Scudiero O, De Boeck K |title=Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations. |journal=Genomics |volume=85 |issue= 5 |pages= 574–81 |year= 2005 |pmid= 15820309 |doi= 10.1016/j.ygeno.2005.02.003 |display-authors=etal}}
* {{cite journal | vauthors = Taudien S, Galgoczy P, Huse K, Reichwald K, Schilhabel M, Szafranski K, Shimizu A, Asakawa S, Frankish A, Loncarevic IF, Shimizu N, Siddiqui R, Platzer M | title = Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence | journal = BMC Genomics | volume = 5 | issue = 1 | pages = 92 | date = December 2004 | pmid = 15588320 | pmc = 544879 | doi = 10.1186/1471-2164-5-92 }}
*{{cite journal | vauthors=Boniotto M, Ventura M, Eskdale J |title=Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. |journal=Genet. Test. |volume=8 |issue= 3 |pages= 325–7 |year= 2005 |pmid= 15727258 |doi=10.1089/gte.2004.8.325 |display-authors=etal}}
* {{cite journal | vauthors = Hollox EJ, Armour JA, Barber JC | title = Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster | journal = American Journal of Human Genetics | volume = 73 | issue = 3 | pages = 591–600 | date = September 2003 | pmid = 12916016 | pmc = 1180683 | doi = 10.1086/378157 }}
*{{cite journal | vauthors=Taudien S, Galgoczy P, Huse K |title=Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence. |journal=BMC Genomics |volume=5 |pages= 92 |year= 2006 |pmid= 15588320 |doi= 10.1186/1471-2164-5-92 | pmc=544879 |display-authors=etal}}
* {{cite journal | vauthors = Semple CA, Rolfe M, Dorin JR | title = Duplication and selection in the evolution of primate beta-defensin genes | journal = Genome Biology | volume = 4 | issue = 5 | pages = R31 | year = 2003 | pmid = 12734011 | pmc = 156587 | doi = 10.1186/gb-2003-4-5-r31 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
* {{cite journal | vauthors = Yamaguchi Y, Nagase T, Makita R, Fukuhara S, Tomita T, Tominaga T, Kurihara H, Ouchi Y | title = Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice | journal = Journal of Immunology | volume = 169 | issue = 5 | pages = 2516–23 | date = September 2002 | pmid = 12193721 | doi = 10.4049/jimmunol.169.5.2516 }}
*{{cite journal | vauthors=Hollox EJ, Armour JA, Barber JC |title=Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. |journal=Am. J. Hum. Genet. |volume=73 |issue= 3 |pages= 591–600 |year= 2003 |pmid= 12916016 |doi= 10.1086/378157 | pmc=1180683 }}
* {{cite journal | vauthors = Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB | title = Discovery of five conserved beta -defensin gene clusters using a computational search strategy | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 4 | pages = 2129–33 | date = February 2002 | pmid = 11854508 | pmc = 122330 | doi = 10.1073/pnas.042692699 }}
*{{cite journal | vauthors=Semple CA, Rolfe M, Dorin JR |title=Duplication and selection in the evolution of primate beta-defensin genes. |journal=Genome Biol. |volume=4 |issue= 5 |pages= R31 |year= 2003 |pmid= 12734011 |doi=10.1186/gb-2003-4-5-r31 | pmc=156587  }}
* {{cite journal | vauthors = García JR, Krause A, Schulz S, Rodríguez-Jiménez FJ, Klüver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann WG | title = Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity | journal = FASEB Journal | volume = 15 | issue = 10 | pages = 1819–21 | date = August 2001 | pmid = 11481241 | doi = 10.1096/fj.00-0865fje }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Yamaguchi Y, Nagase T, Makita R |title=Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2516–23 |year= 2002 |pmid= 12193721 |doi= 10.4049/jimmunol.169.5.2516|display-authors=etal}}
*{{cite journal | vauthors=Schutte BC, Mitros JP, Bartlett JA |title=Discovery of five conserved beta -defensin gene clusters using a computational search strategy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 4 |pages= 2129–33 |year= 2002 |pmid= 11854508 |doi= 10.1073/pnas.042692699 | pmc=122330 |display-authors=etal}}
*{{cite journal | vauthors=García JR, Krause A, Schulz S |title=Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. |journal=FASEB J. |volume=15 |issue= 10 |pages= 1819–21 |year= 2001 |pmid= 11481241 |doi= 10.1096/fj.00-0865fje|display-authors=etal}}
}}
{{refend}}
{{refend}}


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[[Category:Defensins]]

Revision as of 01:56, 14 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Beta-defensin 104 is a protein that in humans is encoded by the DEFB104A gene.[1]

Function

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DEFB104A defensin, beta 104A".

Further reading


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