MAGEA12: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Melanoma-associated antigen 12''' is a [[protein]] that in humans is encoded by the ''MAGEA12'' [[gene]].<ref name="pmid8575766">{{cite journal |vauthors=Rogner UC, Wilke K, Steck E, Korn B, Poustka A | title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 | journal = Genomics | volume = 29 | issue = 3 | pages = 725–731 |date=Mar 1996 | pmid = 8575766 | pmc =  | doi = 10.1006/geno.1995.9945 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGEA12 melanoma antigen family A, 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4111| accessdate = }}</ref>
'''Melanoma-associated antigen 12''' is a [[protein]] that in humans is encoded by the ''MAGEA12'' [[gene]].<ref name="pmid8575766">{{cite journal | vauthors = Rogner UC, Wilke K, Steck E, Korn B, Poustka A | title = The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28 | journal = Genomics | volume = 29 | issue = 3 | pages = 725–31 | date = October 1995 | pmid = 8575766 | pmc =  | doi = 10.1006/geno.1995.9945 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGEA12 melanoma antigen family A, 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4111| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first [[exon]]s of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location [[X chromosome|X]]q28. They have been implicated in some hereditary disorders, such as [[dyskeratosis congenita]].<ref name="entrez" />
}}


==References==
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first [[exon]]s of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location [[X chromosome|X]]q28. They have been implicated in some hereditary disorders, such as [[dyskeratosis congenita]].<ref name="entrez" />
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C | title = Structure, chromosomal localization, and expression of 12 genes of the MAGE family | journal = Immunogenetics | volume = 40 | issue = 5 | pages = 360–9 | year = 1994 | pmid = 7927540 | doi = 10.1007/BF01246677 }}
| citations =
* {{cite journal | vauthors = Ding M, Beck RJ, Keller CJ, Fenton RG | title = Cloning and analysis of MAGE-1-related genes | journal = Biochemical and Biophysical Research Communications | volume = 202 | issue = 1 | pages = 549–55 | date = July 1994 | pmid = 8037761 | doi = 10.1006/bbrc.1994.1963 }}
*{{cite journal | author=De Plaen E |title=Structure, chromosomal localization, and expression of 12 genes of the MAGE family |journal=Immunogenetics |volume=40 |issue= 5 |pages= 360–369 |year= 1994 |pmid= 7927540 |doi=10.1007/BF01246677 |name-list-format=vanc| author2=Arden K  | author3=Traversari C  | display-authors=3  | last4=Szikora  | first4=Jean-Pierre  | last5=Smet  | first5=Charles  | last6=Brasseur  | first6=Francis  | last7=Bruggen  | first7=Pierre  | last8=Leth�  | first8=Bernard  | last9=Lurquin  | first9=Christophe  }}
* {{cite journal | vauthors = De Smet C, Lurquin C, van der Bruggen P, De Plaen E, Brasseur F, Boon T | title = Sequence and expression pattern of the human MAGE2 gene | journal = Immunogenetics | volume = 39 | issue = 2 | pages = 121–9 | year = 1994 | pmid = 8276455 | doi = 10.1007/bf00188615 }}
*{{cite journal |vauthors=Ding M, Beck RJ, Keller CJ, Fenton RG |title=Cloning and analysis of MAGE-1-related genes |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 1 |pages= 549–555 |year= 1994 |pmid= 8037761 |doi= 10.1006/bbrc.1994.1963 }}
* {{cite journal | vauthors = Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD | title = Comparative genome sequence analysis of the Bpa/Str region in mouse and Man | journal = Genome Research | volume = 10 | issue = 6 | pages = 758–75 | date = June 2000 | pmid = 10854409 | pmc = 310879 | doi = 10.1101/gr.10.6.758 }}
*{{cite journal | author=De Smet C |title=Sequence and expression pattern of the human MAGE2 gene |journal=Immunogenetics |volume=39 |issue= 2 |pages= 121–9 |year= 1994 |pmid= 8276455 |doi= 10.1007/bf00188615|name-list-format=vanc| author2=Lurquin C  | author3=van der Bruggen P  | display-authors=3  | last4=De Plaen  | first4=E  | last5=Brasseur  | first5=F  | last6=Boon  | first6=T  }}
* {{cite journal | vauthors = Wischnewski F, Friese O, Pantel K, Schwarzenbach H | title = Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters | journal = Molecular Cancer Research | volume = 5 | issue = 7 | pages = 749–59 | date = July 2007 | pmid = 17634428 | doi = 10.1158/1541-7786.MCR-06-0364 }}
*{{cite journal | author=Mallon AM |title=Comparative genome sequence analysis of the Bpa/Str region in mouse and Man |journal=Genome Res. |volume=10 |issue= 6 |pages= 758–775 |year= 2000 |pmid= 10854409 |doi=10.1101/gr.10.6.758  | pmc=310879 |name-list-format=vanc| author2=Platzer M  | author3=Bate R  | display-authors=3  | last4=Gloeckner  | first4=G  | last5=Botcherby  | first5=MR  | last6=Nordsiek  | first6=G  | last7=Strivens  | first7=MA  | last8=Kioschis  | first8=P  | last9=Dangel  | first9=A  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F. | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal |vauthors=Wischnewski F, Friese O, Pantel K, Schwarzenbach H |title=Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters |journal=Mol. Cancer Res. |volume=5 |issue= 7 |pages= 749–759 |year= 2007 |pmid= 17634428 |doi= 10.1158/1541-7786.MCR-06-0364 }}
}}
{{refend}}
{{refend}}
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Latest revision as of 06:41, 22 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melanoma-associated antigen 12 is a protein that in humans is encoded by the MAGEA12 gene.[1][2]

Function

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita.[2]

References

  1. ↑ Rogner UC, Wilke K, Steck E, Korn B, Poustka A (October 1995). "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics. 29 (3): 725–31. doi:10.1006/geno.1995.9945. PMID 8575766.
  2. ↑ 2.0 2.1 "Entrez Gene: MAGEA12 melanoma antigen family A, 12".

Further reading

  • De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, van der Bruggen P, Lethé B, Lurquin C (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540.
  • Ding M, Beck RJ, Keller CJ, Fenton RG (July 1994). "Cloning and analysis of MAGE-1-related genes". Biochemical and Biophysical Research Communications. 202 (1): 549–55. doi:10.1006/bbrc.1994.1963. PMID 8037761.
  • De Smet C, Lurquin C, van der Bruggen P, De Plaen E, Brasseur F, Boon T (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9. doi:10.1007/bf00188615. PMID 8276455.
  • Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (June 2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Research. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
  • Wischnewski F, Friese O, Pantel K, Schwarzenbach H (July 2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Molecular Cancer Research. 5 (7): 749–59. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.
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