Hepatocellular carcinoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Hepatocellular carcinoma may be classified according to the histological subtypes. The staging of HCC is based on the TNM staging system. | |||
==Classification == | |||
*Hepatocellular carcinoma may be classified according to the histological subtypes:<ref name="pmid26838979">{{cite journal |vauthors=Shafizadeh N, Kakar S |title=Hepatocellular Carcinoma: Histologic Subtypes |journal=Surg Pathol Clin |volume=6 |issue=2 |pages=367–84 |year=2013 |pmid=26838979 |doi=10.1016/j.path.2013.03.007 |url=}}</ref> | |||
= | |||
**Fibrolamellar carcinoma sarcomatoid HCC | **Fibrolamellar carcinoma sarcomatoid HCC | ||
**Undifferentiated carcinoma | **Undifferentiated carcinoma | ||
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==Staging== | ==Staging== | ||
According to the TNM staging system, there are four stages of hepatocellular carcinoma based on the tumor size, lymph node involvement, and distant metastasis.<ref name="cancerca"> Canadian Cancer Society.http://www.cancer.ca/en/cancer-information/cancer-type/liver/staging/?region=ab</ref> | According to the TNM staging system, there are four stages of hepatocellular carcinoma based on the tumor size, lymph node involvement, and distant metastasis.<ref name="cancerca">Canadian Cancer Society.http://www.cancer.ca/en/cancer-information/cancer-type/liver/staging/?region=ab</ref> | ||
===Primary tumor=== | ===Primary tumor=== | ||
{| {{table}} | {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | ||
||TX | ||TX | ||
||Primary tumour cannot be assessed | ||Primary tumour cannot be assessed | ||
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===Regional lymph node=== | ===Regional lymph node=== | ||
{| {{table}} | {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | ||
| NX||Regional lymph nodes cannot be assessed | | NX||Regional lymph nodes cannot be assessed | ||
|- | |- | ||
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===Distance metastasis=== | ===Distance metastasis=== | ||
{| {{table}} | {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | ||
| M0||No distant metastasis | | M0||No distant metastasis | ||
|- | |- |
Revision as of 04:54, 27 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {SH}
Overview
Hepatocellular carcinoma may be classified according to the histological subtypes. The staging of HCC is based on the TNM staging system.
Classification
- Hepatocellular carcinoma may be classified according to the histological subtypes:[1]
- Fibrolamellar carcinoma sarcomatoid HCC
- Undifferentiated carcinoma
- Combined HCC-cholangiocarcinoma (HCC-CC)
- Lymphoepithelioma
Staging
According to the TNM staging system, there are four stages of hepatocellular carcinoma based on the tumor size, lymph node involvement, and distant metastasis.[2]
Primary tumor
TX | Primary tumour cannot be assessed |
T0 | No evidence of primary tumour |
T1 | A single tumour with no invasion into the blood vessels of the liver |
T2 | A single tumour with invasion into the blood vessels or multiple tumours, none more than 5 cm in size |
T3a | Multiple tumours, with any tumour larger than 5 cm |
T3b | The tumour has grown into either the portal or hepatic vein |
T4 | The tumour has grown into nearby organs (other than the gallbladder) or the tumour has grown into the layer of tissue that covers the organs in the abdomen (visceral peritoneum) |
Regional lymph node
NX | Regional lymph nodes cannot be assessed |
NX | No regional lymph node metastasis |
NX | Regional lymph node metastasis |
Distance metastasis
M0 | No distant metastasis |
M1 | Distant metastasis |
References
- ↑ Shafizadeh N, Kakar S (2013). "Hepatocellular Carcinoma: Histologic Subtypes". Surg Pathol Clin. 6 (2): 367–84. doi:10.1016/j.path.2013.03.007. PMID 26838979.
- ↑ Canadian Cancer Society.http://www.cancer.ca/en/cancer-information/cancer-type/liver/staging/?region=ab