Linitis plastica causes: Difference between revisions
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==Overview== | ==Overview== | ||
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by | Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in [[CDH1 (gene)|CDH1]] gene. [[CDH1 (gene)|CDH1]] gene codes for [[Cadherin|E-cadherin]] adhesion protein. Secondarily, linitis plastica may be caused by [[metastasis]] to the [[stomach]] or by the [[Lye|ingestion of lye]]. | ||
==Causes== | ==Causes== | ||
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===Secondary causes=== | ===Secondary causes=== | ||
*Lye ingestion | *[[Lye]] ingestion | ||
*Metastatic infiltration of the stomach by: | *[[Metastasis|Metastatic]] infiltration of the stomach by: | ||
**Lung cancer | **[[Lung cancer]] | ||
**Breast cancer | **[[Breast cancer]] | ||
**Non- | **[[Non-Hodgkin lymphoma]]<ref name="pmid8888226">{{cite journal |vauthors=Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC |title=Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica |journal=Radiology |volume=201 |issue=2 |pages=375–8 |year=1996 |pmid=8888226 |doi=10.1148/radiology.201.2.8888226 |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 17:07, 8 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.
Causes
Primary Causes
- Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.[1]
- Somatic mutations in the CDH1 gene can occur by:
- Hypermethylation
- Loss of heterozygosity
- Silencing mutations
Secondary causes
- Lye ingestion
- Metastatic infiltration of the stomach by:
References
- ↑ Graziano F, Humar B, Guilford P (2003). "The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice". Ann. Oncol. 14 (12): 1705–13. PMID 14630673.
- ↑ Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC (1996). "Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica". Radiology. 201 (2): 375–8. doi:10.1148/radiology.201.2.8888226. PMID 8888226.