Ischemic colitis natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Hamid Qazi (talk | contribs)
nocaptcha
2,981 edits
Hamid Qazi (talk | contribs)
nocaptcha
2,981 edits
No edit summary
Line 19: Line 19:
***These patients present with persistent symptoms or recurrent episodes of pain, per-rectal bleeding, diarrhoea, and segmental colitis on imaging.  
***These patients present with persistent symptoms or recurrent episodes of pain, per-rectal bleeding, diarrhoea, and segmental colitis on imaging.  
***Resection is often curative.
***Resection is often curative.
**Ischaemic colonic stricture  
**Ischemic colonic stricture  
***This may be detected acutely, however, more frequently is found at follow-up endoscopy.
***This may be detected acutely, however, more frequently is found at follow-up endoscopy.
**Gangrenous colitis  
**Gangrenous colitis  

Revision as of 18:33, 8 January 2018

Colitis Main Page

Ischemic colitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Ischemic colitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Abdominal X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ischemic colitis natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ischemic colitis natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA onIschemic colitis natural history, complications and prognosis

CDC on Ischemic colitis natural history, complications and prognosis

Ischemic colitis natural history, complications and prognosis in the news

Blogs on Ischemic colitis natural history, complications and prognosis

Directions to Hospitals Treating Ischemic colitis

Risk calculators and risk factors for Ischemic colitis natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]

Overview

Ischemic colitis can span a wide spectrum of severity. Majority of patients are treated supportively and recover fully, while a minority with very severe ischemia may develop sepsis and become critically ill. Most patients make a full recovery. Occasionally, after severe ischemia, patients may develop long-term complications such as a stricture or chronic colitis.

Natural History

The natural history of ischemic colitis is as follows:[1][2][3][4][5][6][7][8][9][10]

  • The symptoms of ischemic colitis usually develop in the sixth decade of life, and start with symptoms such as abdominal pain, bloody diarrhea, and vomiting.
  • Ischemic colitis can progress to different stages depending on the elapsed time:
    • Reversible ischemic colopathy
      • This type is characterized by submucosal haemorrhage at endoscopy, with involvement of superficial mucosa.
      • It is typically self-limiting.
    • Transient: the most common form
      • These patients present with abdominal pain, per-rectal bleeding and full-thickness involvement of the mucosa.
    • Chronic segmental or chronic ulcerative
      • These patients present with persistent symptoms or recurrent episodes of pain, per-rectal bleeding, diarrhoea, and segmental colitis on imaging.
      • Resection is often curative.
    • Ischemic colonic stricture
      • This may be detected acutely, however, more frequently is found at follow-up endoscopy.
    • Gangrenous colitis
      • This should be suspected when there is increasing abdominal pain, signs of local or generalized peritonitis, fevers or associated ileus.
    • Universal fulminant pancolitis
      • This presents acutely with severe symptoms, progressive transmural infarction and necrosis of the entire colon, resultant sepsis and perforation.
      • 75% mortality rate.
      • These patients present with sepsis, severe abdominal pain, peritonitis and per-rectal bleeding.

Complications

The complications of ischemic colitis are as follows:[11][12][13][14]

  • About 20% of patients with acute ischemic colitis may develop a long-term complication known as chronic ischemic colitis.
    • Symptoms can include recurrent infections, bloody diarrhea, weight loss, and chronic abdominal pain.
    • Chronic ischemic colitis is often treated with surgical removal of the chronically diseased portion of the bowel.
  • A colonic stricture is a band of scar tissue which forms as a result of the ischemic injury and narrows the lumen of the colon.
    • Strictures are often treated observantly; they may heal spontaneously over 12-24 months.
    • If a bowel obstruction develops as a result of the stricture, surgical resection is the usual treatment although endoscopic dilatation and stenting have also been employed.

Prognosis

The prognosis of ischemic colitis is as follows:[15][16]

  • Majority of patients with ischemic colitis recovery fully, although the prognosis depends on the severity of the ischemia.
  • Patients with pre-existing peripheral vascular disease or ischemia of the ascending (right) colon may be at increased risk for complications or death.
  • Non-gangrenous ischemic colitis, which comprises the majority of cases, is associated with a mortality rate of approximately 6%.
    • Minority of patients who develop gangrene as a result of colonic ischemia have a mortality rate of 50-75% with surgical treatment.
    • Mortality rate is almost 100% without surgical intervention.

References

  1. ↑ Hunter GC, Guernsey JM (1988). "Mesenteric ischemia". Med. Clin. North Am. 72 (5): 1091–115. PMID 3045452.
  2. ↑ Nikolic, Amanda L.; Keck, James O. (2017). "Ischaemic colitis: uncertainty in diagnosis, pathophysiology and management". ANZ Journal of Surgery. doi:10.1111/ans.14237. ISSN 1445-1433.
  3. ↑ Montoro, Miguel A.; Brandt, Lawrence J.; Santolaria, Santos; Gomollon, Fernando; Puértolas, Belén Sánchez; Vera, Jesús; Bujanda, Luis.; Cosme, Angel; Cabriada, José Luis; Durán, Margarita; Mata, Laura; Santamaría, Ana; Ceña, Gloria; Blas, Jose Manuel; Ponce, Julio; Ponce, Marta; Rodrigo, Luis; Ortiz, Jacobo; Muñoz, Carmen; Arozena, Gloria; Ginard, Daniel; López-Serrano, Antonio; Castro, Manuel; Sans, Miquel; Campo, Rafael; Casalots, Alex; Orive, Víctor; Loizate, Alberto; Titó, Lluçia; Portabella, Eva; Otazua, Pedro; Calvo, M.; Botella, Maria Teresa; Thomson, Concepción; Mundi, Jose Luis; Quintero, Enrique; Nicolás, David; Borda, Fernando; Martinez, Benito; Gisbert, Javier P.; Chaparro, María; Bernadó, Alfredo Jimenez; Gómez-Camacho, Federico; Cerezo, Antonio; Nuñez, Enrique Casal (2010). "Clinical patterns and outcomes of ischaemic colitis: Results of the Working Group for the Study of Ischaemic Colitis in Spain (CIE study)". Scandinavian Journal of Gastroenterology. 46 (2): 236–246. doi:10.3109/00365521.2010.525794. ISSN 0036-5521.
  4. ↑ . doi:10.3109/10.3748/wjg.14.7302. Missing or empty |title= (help)
  5. ↑ O’Neill, Stephen; Elder, Kenny; Harrison, Sarah J.; Yalamarthi, Satheesh (2011). "Predictors of severity in ischaemic colitis". International Journal of Colorectal Disease. 27 (2): 187–191. doi:10.1007/s00384-011-1301-x. ISSN 0179-1958.
  6. ↑ Medina C, Vilaseca J, Videla S, Fabra R, Armengol-Miro J, Malagelada J (2004). "Outcome of patients with ischemic colitis: review of fifty-three cases". Dis Colon Rectum. 47 (2): 180–4. PMID 15043287.
  7. ↑ Simi M, Pietroletti R, Navarra L, Leardi S (1995). "Bowel stricture due to ischemic colitis: report of three cases requiring surgery". Hepatogastroenterology. 42 (3): 279–81. PMID 7590579.
  8. ↑ Boley, SJ, Brandt, LJ, Veith, FJ. Ischemic disorders of the intestines. Curr Probl Surg 1978; 15:1.
  9. ↑ Hunter G, Guernsey J (1988). "Mesenteric ischemia". Med Clin North Am. 72 (5): 1091–115. PMID 3045452.
  10. ↑ Cappell M (1998). "Intestinal (mesenteric) vasculopathy. II. Ischemic colitis and chronic mesenteric ischemia". Gastroenterol Clin North Am. 27 (4): 827–60, vi. PMID 9890115.
  11. ↑ Cappell M (1998). "Intestinal (mesenteric) vasculopathy. II. Ischemic colitis and chronic mesenteric ischemia". Gastroenterol Clin North Am. 27 (4): 827–60, vi. PMID 9890115.
  12. ↑ Simi M, Pietroletti R, Navarra L, Leardi S (1995). "Bowel stricture due to ischemic colitis: report of three cases requiring surgery". Hepatogastroenterology. 42 (3): 279–81. PMID 7590579.
  13. ↑ Oz M, Forde K (1990). "Endoscopic alternatives in the management of colonic strictures". Surgery. 108 (3): 513–9. PMID 2396196.
  14. ↑ Profili S, Bifulco V, Meloni G, Demelas L, Niolu P, Manzoni M (1996). "self-expandable uncoated metallic prosthesis". Radiol Med (Torino). 91 (5): 665–7. PMID 8693144.
  15. ↑ Longo W, Ballantyne G, Gusberg R (1992). "Ischemic colitis: patterns and prognosis". Dis Colon Rectum. 35 (8): 726–30. PMID 1643995.
  16. ↑ Parish K, Chapman W, Williams L (1991). "Ischemic colitis. An ever-changing spectrum?". Am Surg. 57 (2): 118–21. PMID 1992867.


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Ischemic_colitis_natural_history,_complications_and_prognosis&oldid=1428494"