Gastritis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]

Overview

Gastritis depending on the causes may be classified into acute gastritis, chronic gastritis, atrophic gastritis, and H. pylori associated gastritis. In acute gastritis, the majority of patients, the initial acute phase of gastritis is subclinical and is of short duration (about 7 to 10 days). Acute gastritis also referred to as reactive gastritis occurs as a result of the trigger by factors such as NSAIDs, stress, bile reflux, radiation, alcohol abuse, cocaine addiction, and ischemic damage. In chronic gastritis, the H. pylori infection persists leading to accumulation of large number chronic inflammatory cells leading to active chronic gastritis.

Pathophysiology

Acute gastritis

• Acute gastritis also referred to as reactive gastritis occurs as a result of the trigger by factors such as NSAIDs, stress, bile reflux, radiation, alcohol abuse, cocaine addiction, and ischemic damage. The outcome of these triggers may result in ulcers, hemorrhage and erosion of the gastric mucosa.

Pathogenesis

• The decrease in the prostaglndin synthesis is thought to be the reason for the injury to the gastric mucosa. The gastric mucosa is safeguarded from the deleterious effects of the gastric acid by mechanisms promoted by the prostaglandins.
• In the majority of patients, the initial acute phase of gastritis is subclinical and is of short duration (about 7 to 10 days).
• In the majority of cases of H. pylori infection, the infection is not eliminated and there will be gradual accumulation of chronic inflammatory cells over the next 3 or 4 weeks.. In H. pylori infection, the organisms are spontaneously cleared in a small minority of people, especially in childhood.
• Following transmission, H. pylori penetrates the gastric mucosa and multiplies close to the surface epithelial cells. Following adhesion to epithelial cells, the bacteria releases lipopolysaccharides (endotoxin) and chemotactic mediators which penetrate the surface epithelial cells.

Microscopic pathology

Histological features observed such as:

• Hyperemia
• Acute inflammation
• Increased polymorphonuclear neutrophil in the superficial lamina propria
• Erosion of the surface epithelium
• Sloughing
• Mucosal necrosis to a greater extent
• Scarring (later sequelae)

Chronic gastritis

In the majority of cases, the H. pylori infection persists leading to accumulation of large number chronic inflammatory cells leading to active chronic gastritis.

Pathogenesis

• The major diagnostic feature of chronic gastritis is an influx of lymphocytes and plasma cells (normally the antral mucosa is devoid of plasma cells and lymphocytes). Hence the presence of these cells is indicative of gastritis.
• H. pylori colonizes more in the antrum than the corpus. Hence there is increased inflammatory cell infiltration in the antrum.
• The direct acting antigens of H. pylori like lipopolysaccharides, urease etc along with interleukins 1 and 6, activate T-helper cells which produce the variety of cytokines including IL4, IL5, and IL6.
• These interleukins differentiate into plasma cells releasing cytokines and anti-H.pylori infection like IgM-opsonizing and complement-fixing antibodies.
• The main role of the mucosa in the immune response is that the IgA prevents bacterial adhesion and IgG causes opsonization and complement activation.
• Due to the acidic environment, the antibodies produced quickly lose their adhesive properties and catalase produced by H. pylori protects against polymorphs.
• However, this immune response is insufficient to eradicate the organism leading to the development of immune response directed towards preventing the damaging effects of the H. pylori.
• Hence the persistent antigenic stimulation leads to the formation of lymphoid follicles, which is the consistent feature of chronic H. pylori infection.
• These lymphoid follicles in the gastric mucosa constitutes mucosa-associated lymphoid tissue (MALT) from which gastric marginal zone B-cell lymphoma (MALToma) arises.

Also, these polymorphs accumulate around the pit isthmus, which is a proliferative compartment, causing lethal damage to stem cells resulting in glandular atrophy.

Microscopic pathology

• Variable epithelial degeneration
• Neutrophil infiltration in the epithelium and the lamina propria
• Variable H. pylori colonization
• Lymphocytes and plasma cell infiltration
• Lymphoid follicles (typical feature of chronic gastritis)
• Around one-fifth of cases with an inflamed cardia may undergo intestinal metaplasia.

• 

  Chronic gastritis - Intermedicate Magnification, By Nephron (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons

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  Chronic gastritis - Very-High Magnification, By Nephron (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons

Sydney system for grading of chronic gastritis

Sydney system for grading of Chronic Gastritis
Feature	Definition	Grading guidelines
Chronic inflammation	Increased lymphocytes and plasma cells in lamina propria	Mild, moderate or severe increase in density
Activity	Neutrophilic infiltrates of the lamina propria, pits or surface epithelium	Mild: less than one-third of pits and surface infiltrated Moderate: one-third to two-thirds Severe: more than two-thirds
Atrophy	Loss of specialized glands from either antrum or corpus	Mild, moderate, or severe loss
Helicobacter pylori	H. pylori density	Mild colonization: scattered organisms covering less than one-third of the surface Moderate colonization: intermediate numbers Severe colonization: large clusters or a continuous layer over two-thirds of surface
Intestinal Metaplasia	Intestinal metaplasia of the epithelium	Mild: less than one-third of mucosa involved Moderate: one-third to two-thirds Severe: more than two-thirds

Atrophic Gastritis

Atrophy of stomach is defined as loss of glandular tissue due to continuous mucosal injury. This leads to thinning of gastric mucosa.

• The prevalence and severity of atrophy of stomach increases with age among the patient's chronic gastritis due to longer duration of H. pylori infection.
• Due to glandular atrophy, the prevalence of H. pylori positivity decreases. The main reasons are as follows:

• Due to intestinal metaplasia that is usually present in atrophic stomach, the organisms are absent as they usually colonize only gastric epithelium.
• As H. pylori requires partially acidic environment to thrive, hypochlorhydria creats hostile environment to H. pylori to survive.
• The metaplastic epithelium secretes acidic glycoproteins which create the most hostile environment for H. pylori.

• Hence, based on above reasons, failure to demonstrate H. pylori does not deny the role of the organism in atrophic gastritis.

Pathogenesis

• The continuous mucosal injury due to long-standing H. pylori infection, leads to atrophy of stomach.
• This continuous pathological process results in erosion or ulceration of the mucosa leading to the destruction of the glandular layer and followed by fibrous replacement.
• The destruction of the glandular basement membrane and the sheath of supporting cells prevents orderly regeneration. This uneven regeneration follows a divergent differentiation pathway producing metaplastic glands (pseudo-pyloric appearance) which are composed of cells of the 'ulcer-associated cell lineage' (UACL).

Microscopic pathology

• Reduced number of oxyntic cells. No intestinal metaplasia
• The mucosa is infiltrated with neutrophils
• H. pylori is not seen on H&E stain.
• Immunohistochemical stain of H. pylori detects the organisms.

Atrophic Gastritis, By Radioxoma (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

Gross pathology

• Erosive Gastritis:
  • Erosive gastritis results due to the loss of superficial epithelium causing and it does not extend beyond the muscularis mucosa.
  • The crypts may present as dilated and contain acute inflammatory cells.

Erosive Gastritis, By Amadalvarez (Own work) [CC BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0)], via Wikimedia Commons

Videos

Chronic gastritis {{#ev:youtube|Wvn5TiiIB4Q}}

Atrophic gastritis {{#ev:youtube|760GB43AZqE}}