Linitis plastica other diagnostic studies: Difference between revisions
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
==Overview== | ==Overview== | ||
Brush cytology may be helpful in the diagnosis of linitis plastica. Brush cytology has the ability to increase the sensitivity of even a single biopsy carried out by endoscopic ultrasound. If bleeding is a concern in the patient, brush cytology is able to take samples of the mucosa without bleeding. Immunohistochemical staining then confirms the diagnosis of linitis plastica with the finding of signet ring cells. | Brush cytology may be helpful in the diagnosis of linitis plastica. Brush cytology has the ability to increase the sensitivity of even a single biopsy carried out by endoscopic ultrasound. If bleeding is a concern in the patient, brush cytology is able to take samples of the mucosa without bleeding. Immunohistochemical staining then confirms the diagnosis of linitis plastica with the finding of signet ring cells. Genetic testing can be carried out in those who have family history of hereditary diffuse gastric adenocarcinoma and are postive for CDH1 mutation. The risk for developing gastric cancer is high enough to warrant prophylactic gastrectomy. | ||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Brush cytology=== | |||
*Brush cytology with immunohistochemical staining may be helpful in the diagnosis of linitis plastica.<ref name="pmid2028694">{{cite journal |vauthors=Wang HH, Jonasson JG, Ducatman BS |title=Brushing cytology of the upper gastrointestinal tract. Obsolete or not? |journal=Acta Cytol. |volume=35 |issue=2 |pages=195–8 |year=1991 |pmid=2028694 |doi= |url=}}</ref> | *Brush cytology with immunohistochemical staining may be helpful in the diagnosis of linitis plastica.<ref name="pmid2028694">{{cite journal |vauthors=Wang HH, Jonasson JG, Ducatman BS |title=Brushing cytology of the upper gastrointestinal tract. Obsolete or not? |journal=Acta Cytol. |volume=35 |issue=2 |pages=195–8 |year=1991 |pmid=2028694 |doi= |url=}}</ref> | ||
*Brush cytology has the following advantages: | *Brush cytology has the following advantages: | ||
| Line 15: | Line 16: | ||
**Sensitive to poorly differentiated linits plastica | **Sensitive to poorly differentiated linits plastica | ||
===Genetic testing=== | |||
==References== | ==References== | ||
Revision as of 21:08, 11 January 2018
|
Linitis plastica Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Linitis plastica other diagnostic studies On the Web |
|
American Roentgen Ray Society Images of Linitis plastica other diagnostic studies |
|
Risk calculators and risk factors for Linitis plastica other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Brush cytology may be helpful in the diagnosis of linitis plastica. Brush cytology has the ability to increase the sensitivity of even a single biopsy carried out by endoscopic ultrasound. If bleeding is a concern in the patient, brush cytology is able to take samples of the mucosa without bleeding. Immunohistochemical staining then confirms the diagnosis of linitis plastica with the finding of signet ring cells. Genetic testing can be carried out in those who have family history of hereditary diffuse gastric adenocarcinoma and are postive for CDH1 mutation. The risk for developing gastric cancer is high enough to warrant prophylactic gastrectomy.
Other Diagnostic Studies
Brush cytology
- Brush cytology with immunohistochemical staining may be helpful in the diagnosis of linitis plastica.[1]
- Brush cytology has the following advantages:
- No risk of bleeding
- Increased sensitivity of single biopsy
- Sensitive to poorly differentiated linits plastica