Gallbladder cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Gallbladder cancer may be classified according to WHO into various subtypes and are as follows

Classification

Gallbladder carcinoma may be classified according to histology into following subtypes

SUBTYPE	FEATURES
Adenocarcinoma	Sheets, cohesive fragments, acini, and mucin
Papillary adenocarcinoma	Pleomorphism and papillary fragments with vascular core
Mucinous adenocarcinoma	Single cells or cluster and extracellular mucin
Signet ring cell carcinoma	Intracellular mucin with signet ring cells
Adenosquamous carcinoma	Mixture of glandular and squamous components
Squamous cell carcinoma	Necrosis, tadpole cells and atypical keratinized cells
Neuroendocrine carcinoma	Salt and pepper chromatin,anisonucleosis and rosettes
Small cell carcinoma	Absent cytoplasm, Smudge cells, and mitoses
Undifferentiated carcinoma	Pleomorphic cells, abundant necrosis
Spindle cell undifferentiated carcinoma	Undifferciated type with prominent spindle cells
Gaint cell undifferentiated carcinoma	Undifferciated type with predominant giant cells

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