Gallbladder cancer pathophysiology: Difference between revisions

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== Overview ==
== Overview ==
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
== Pathophysiology ==
* It is understood that gallbladder cancer  is the result of two different independent biological pathways
** 1) The most common pathway is a dysplasia-carcinoma which is arising from metaplastic epithelium. It's  a process that would  require a period of approximately 10 years to devlop.<ref name="pmid16724345">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref>
** 2) the second most common pathway is an adenoma-carcinoma sequence.<ref name="pmid167243452">{{cite journal |vauthors=Roa I, de Aretxabala X, Araya JC, Roa J |title=Preneoplastic lesions in gallbladder cancer |journal=J Surg Oncol |volume=93 |issue=8 |pages=615–23 |year=2006 |pmid=16724345 |doi=10.1002/jso.20527 |url=}}</ref>
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== References ==
== References ==
<references />
<references />

Revision as of 02:53, 23 January 2018

Overview

It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.

References

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