Polycythemia vera historical perspective: Difference between revisions
Jump to navigation
Jump to search
Shyam Patel (talk | contribs) |
Shyam Patel (talk | contribs) |
||
| Line 6: | Line 6: | ||
==Historical Perspective== | ==Historical Perspective== | ||
*In '''1892''', Louis Henry Vaquez first described polycythemia vera as a disorder of hematopoietic hyperactivity.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> | *In '''1892''', Louis Henry Vaquez first described polycythemia vera as a disorder of hematopoietic hyperactivity.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> <ref name="pmid21120186">{{cite journal| author=Means RT| title=JAK2 V617F and the evolving paradigm of polycythemia vera. | journal=Korean J Hematol | year= 2010 | volume= 45 | issue= 2 | pages= 90-4 | pmid=21120186 | doi=10.5045/kjh.2010.45.2.90 | pmc=2983020 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21120186 }} </ref> He reports on a patient who had the polycythemia syndrome (elevated hemoglobin) without cardiopulmonary disease. Louis Henry Vasquez was the first person to suggest that the condition of elevated red blood cells could be divided into two categories<ref name="pmid21120186">{{cite journal| author=Means RT| title=JAK2 V617F and the evolving paradigm of polycythemia vera. | journal=Korean J Hematol | year= 2010 | volume= 45 | issue= 2 | pages= 90-4 | pmid=21120186 | doi=10.5045/kjh.2010.45.2.90 | pmc=2983020 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21120186 }} </ref>: | ||
**absolute erythrocytosis (due to elevated [[red blood cell]] mass | |||
**relative erythrocytosis (due to reduced plasma volume but not due to elevated [[red blood cell]] mass) | |||
*In '''1903''', Sir William Olser reinforced the concept of polycythemia vera.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> | *In '''1903''', Sir William Olser reinforced the concept of polycythemia vera.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> He noted that in his clinical practice, patients with [[red blood cell]] elevation had a distinct clinical syndrome.<ref name="pmid21120186">{{cite journal| author=Means RT| title=JAK2 V617F and the evolving paradigm of polycythemia vera. | journal=Korean J Hematol | year= 2010 | volume= 45 | issue= 2 | pages= 90-4 | pmid=21120186 | doi=10.5045/kjh.2010.45.2.90 | pmc=2983020 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21120186 }} </ref> He published a paper on these findings. | ||
*In '''1904''', Wilhelm Turk, a Viennese physician, noted that all hematopoietic lineages, including [[white blood cells]] and [[platelets]], were elevated in polycythemia vera. This suggested that polycythemia vera was not a condition exclusive to the erythroid lineage. This was the first suggestion that paved way for the idea that polycythemia vera was a disorder of the hematopoietic stem cell, as this cell gives rise to all lineages.<ref name="pmid21120186">{{cite journal| author=Means RT| title=JAK2 V617F and the evolving paradigm of polycythemia vera. | journal=Korean J Hematol | year= 2010 | volume= 45 | issue= 2 | pages= 90-4 | pmid=21120186 | doi=10.5045/kjh.2010.45.2.90 | pmc=2983020 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21120186 }} </ref> | |||
*'''In 1908''', Sir William Osler described additional patients with polycythemia vera and wrote a second publication. | |||
*In '''1953''', William Dameshek described myeloproliferative neoplasms as a group of disorders including polycythemia vera, essential thrombocythemia, and myelofibrosis.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> He postulated that polycythemia vera variably reflected bone marrow proliferative activity from an unidentified stimulus. | *In '''1953''', William Dameshek described myeloproliferative neoplasms as a group of disorders including polycythemia vera, essential thrombocythemia, and myelofibrosis.<ref name="pmid27884974">{{cite journal| author=Vannucchi AM| title=From leeches to personalized medicine: evolving concepts in the management of polycythemia vera. | journal=Haematologica | year= 2017 | volume= 102 | issue= 1 | pages= 18-29 | pmid=27884974 | doi=10.3324/haematol.2015.129155 | pmc=5210229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27884974 }} </ref> He postulated that polycythemia vera variably reflected bone marrow proliferative activity from an unidentified stimulus. | ||
Revision as of 06:02, 3 February 2018
|
Polycythemia vera Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia vera historical perspective On the Web |
|
American Roentgen Ray Society Images of Polycythemia vera historical perspective |
|
Risk calculators and risk factors for Polycythemia vera historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
In 2005, a mutation in the JAK2 kinase (V617F) was found in multiple patients with myeloprolifrative neoplasm (including polycythemia vera) by different researchers.[1]
Historical Perspective
- In 1892, Louis Henry Vaquez first described polycythemia vera as a disorder of hematopoietic hyperactivity.[2] [3] He reports on a patient who had the polycythemia syndrome (elevated hemoglobin) without cardiopulmonary disease. Louis Henry Vasquez was the first person to suggest that the condition of elevated red blood cells could be divided into two categories[3]:
- absolute erythrocytosis (due to elevated red blood cell mass
- relative erythrocytosis (due to reduced plasma volume but not due to elevated red blood cell mass)
- In 1903, Sir William Olser reinforced the concept of polycythemia vera.[2] He noted that in his clinical practice, patients with red blood cell elevation had a distinct clinical syndrome.[3] He published a paper on these findings.
- In 1904, Wilhelm Turk, a Viennese physician, noted that all hematopoietic lineages, including white blood cells and platelets, were elevated in polycythemia vera. This suggested that polycythemia vera was not a condition exclusive to the erythroid lineage. This was the first suggestion that paved way for the idea that polycythemia vera was a disorder of the hematopoietic stem cell, as this cell gives rise to all lineages.[3]
- In 1908, Sir William Osler described additional patients with polycythemia vera and wrote a second publication.
- In 1953, William Dameshek described myeloproliferative neoplasms as a group of disorders including polycythemia vera, essential thrombocythemia, and myelofibrosis.[2] He postulated that polycythemia vera variably reflected bone marrow proliferative activity from an unidentified stimulus.
- In 1998, the anti-proliferative effects of interferon-alpha for polycythemia vera were described.[2] Sustained hematologic responses by interferon-alpha were confirmed later via other studies.
- In 2005, multiple groups including those led by William Vainchenker, Ross Levine, Robert Kralovics, and Tony Green first described the JAK2 V617F mutation (in exon 14 of the JAK2 gene) in polycythemia vera.[2][1]
- In 2008, the World Health Organization (WHO) developed a classification for myeloproliferative neoplasms, including polycythemia vera. This classification included the JAK2 V617F mutation (or JAK2 exon 12 mutations) as criteria required for the diagnosis.[2] The hemoglobin threshold for making a diagnosis of polycythemia vera was 18.5 g/dl in men and 16.5 g/dl in women. These hemoglobin values were deemed strong surrogate markers for an absolute increase in red blood cell mass.
- In 2016, the WHO revised the classification scheme and diagnostic criteria for polycythemia vera. The diagnostic criteria now includes hemoglobin greater than 16.5 g/dl in men and 16 g/dl in women, bone marrow biopsy showing hypercellularity in all 3 cell lines, and the presence of a JAK2 mutation (either V617F in exon 14 or a mutation in exon 12). These constitute the major criteria. The minor criteria is a subnormal erythropoietin level.
References
- ↑ 1.0 1.1 Gäbler K, Behrmann I, Haan C (2013). "JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms". JAKSTAT. 2 (3): e25025. doi:10.4161/jkst.25025. PMC 3772115. PMID 24069563.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Vannucchi AM (2017). "From leeches to personalized medicine: evolving concepts in the management of polycythemia vera". Haematologica. 102 (1): 18–29. doi:10.3324/haematol.2015.129155. PMC 5210229. PMID 27884974.
- ↑ 3.0 3.1 3.2 3.3 Means RT (2010). "JAK2 V617F and the evolving paradigm of polycythemia vera". Korean J Hematol. 45 (2): 90–4. doi:10.5045/kjh.2010.45.2.90. PMC 2983020. PMID 21120186.