Anal fissure pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
* | *Although constipation or anal trauma was supposed to instigate the fissure,the exact pathogenesis of anal fissure is not fully understood.<ref name="pmid22379402">{{cite journal |vauthors=Zaghiyan KN, Fleshner P |title=Anal fissure |journal=Clin Colon Rectal Surg |volume=24 |issue=1 |pages=22–30 |year=2011 |pmid=22379402 |pmc=3140330 |doi=10.1055/s-0031-1272820 |url=}}</ref> | ||
*It is understood that anal fissure is the result of | *It is understood that anal fissure is the result of either anal trauma (by hard stools/diarrhea), perfusion defects with ischemia caused due to increased anal pressures and decreased blood flow or increased anal sphincter tone. | ||
==Associated Conditions== | ==Associated Conditions== | ||
* [[Crohn's disease]] | |||
* [[HIV AIDS]] | |||
* Previous anal surgery | |||
* [[Anal cancer]] | |||
==Gross Pathology== | ==Gross Pathology== | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
Revision as of 15:00, 24 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
Overview
The exact pathogenesis of anal fissure is not fully understood. It is thought that anal fissure is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
anal fissure arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
OR
The progression to anal fissure usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- Although constipation or anal trauma was supposed to instigate the fissure,the exact pathogenesis of anal fissure is not fully understood.[2]
- It is understood that anal fissure is the result of either anal trauma (by hard stools/diarrhea), perfusion defects with ischemia caused due to increased anal pressures and decreased blood flow or increased anal sphincter tone.
Associated Conditions
- Crohn's disease
- HIV AIDS
- Previous anal surgery
- Anal cancer
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of anal fissure.
References
- ↑ Source=http://www.surgwiki.com/wiki/File:Ch31-fig1.jpg
- ↑ Zaghiyan KN, Fleshner P (2011). "Anal fissure". Clin Colon Rectal Surg. 24 (1): 22–30. doi:10.1055/s-0031-1272820. PMC 3140330. PMID 22379402.
