Sjögren's syndrome pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
ُ[[Sjögren's syndrome]] is a chronic [[Autoimmune disease|auto-immune]] disorder that can affect several organ systems. Both genetic and immune factors contribute to the [[pathogenesis]] of the disease. [[Lymphocyte|Lymphocytes]] | ُ[[Sjögren's syndrome]] is a chronic [[Autoimmune disease|auto-immune]] disorder that can affect several organ systems. Both genetic and immune factors contribute to the [[pathogenesis]] of the disease. [[Lymphocyte|Lymphocytes]] infiltrate the [[lacrimal]] and [[Salivary gland|salivary]] glands and impair their function, hence causing the main characteristic [[Symptom|symptoms]] of the disease- dry mouth ([[keratoconjunctivitis sicca]]) and eyes ([[xerostomia]]). [[CD4|CD4+]] [[T cell|T-cells]] are predominant in mild and moderate salivary gland infiltrations, while [[B cell|B cells]] play the major role in severe lesions <ref name="pmid19889514">{{cite journal| author=Christodoulou MI, Kapsogeorgou EK, Moutsopoulos HM| title=Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome. | journal=J Autoimmun | year= 2010 | volume= 34 | issue= 4 | pages= 400-7 | pmid=19889514 | doi=10.1016/j.jaut.2009.10.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19889514 }}</ref>. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The [[pathogenesis]] of [[Sjögren's syndrome]] can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref>. | The [[pathogenesis]] of [[Sjögren's syndrome]] can be linked to both genetic and nongenetic components <ref name="pmid23846338">{{cite journal| author=Mavragani CP, Nezos A, Moutsopoulos HM| title=New advances in the classification, pathogenesis and treatment of Sjogren's syndrome. | journal=Curr Opin Rheumatol | year= 2013 | volume= 25 | issue= 5 | pages= 623-9 | pmid=23846338 | doi=10.1097/BOR.0b013e328363eaa5 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23846338 }} </ref>. | ||
* '''Genetic components:''' | * '''Genetic components:''' | ||
Although multiple genes are found to be associated with ُ[[Sjögren's syndrome]], evidence suggests genes that encode [[Major histocompatibility complex|Major Histocompatibility Complex]] (MHC), particularly [[Human leukocyte antigen|HLA]] genes, play an important role in the disease. | |||
* '''Immune-mediated components:''' | |||
==References== | ==References== | ||
Revision as of 18:02, 28 January 2018
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Overview
ُSjögren's syndrome is a chronic auto-immune disorder that can affect several organ systems. Both genetic and immune factors contribute to the pathogenesis of the disease. Lymphocytes infiltrate the lacrimal and salivary glands and impair their function, hence causing the main characteristic symptoms of the disease- dry mouth (keratoconjunctivitis sicca) and eyes (xerostomia). CD4+ T-cells are predominant in mild and moderate salivary gland infiltrations, while B cells play the major role in severe lesions [1].
Pathophysiology
The pathogenesis of Sjögren's syndrome can be linked to both genetic and nongenetic components [2].
- Genetic components:
Although multiple genes are found to be associated with ُSjögren's syndrome, evidence suggests genes that encode Major Histocompatibility Complex (MHC), particularly HLA genes, play an important role in the disease.
- Immune-mediated components:
References
- ↑ Christodoulou MI, Kapsogeorgou EK, Moutsopoulos HM (2010). "Characteristics of the minor salivary gland infiltrates in Sjögren's syndrome". J Autoimmun. 34 (4): 400–7. doi:10.1016/j.jaut.2009.10.004. PMID 19889514.
- ↑ Mavragani CP, Nezos A, Moutsopoulos HM (2013). "New advances in the classification, pathogenesis and treatment of Sjogren's syndrome". Curr Opin Rheumatol. 25 (5): 623–9. doi:10.1097/BOR.0b013e328363eaa5. PMID 23846338.