Gastric outlet obstruction: Difference between revisions

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==Pathophysiology==
==Pathophysiology==
Gastric Outlet Obstruction (GOO) may be caused by intrinsic or extrinsic pathologies that involve the [[antrum]] and the [[pylorus]].
It is understood that GOO is the result of multiple intrinsic (lumen & wall) or extrinsic (neighbouring structures) pathologies that involve the [[antrum]] and the [[pylorus]].
* Intrinsic [[obstruction]]:  
* Intrinsic [[obstruction]]: Conditions involving infiltration, scar formation or [[inflammation]] of [[antrum]] and the [[pylorus]] may lead to intrinsic obstruction and GOO.
** Infiltration, scar formation or [[inflammation]] of these structures leads to intrinsic obstruction, resulting in GOO.
* Extrinsic [[obstruction]]: Any malignancy of neighboring structures such as duodenum, liver, gallbladder and pancreas may lead to extrinsic [[obstruction]] of gastric outlet.
* Extrinsic [[obstruction]]:  
** [[Cancer|Malignancy]] of any of these neighboring structures may lead to extrinsic [[obstruction]] of the gastric outlet:
*** [[Duodenum]]
*** [[Liver]]
*** [[Gallbladder]]
*** [[Pancreas]]


==Causes==
==Causes==
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==== Benign causes ====
==== Benign causes ====
[[Acquired disorder|Acquired]] causes of gastric outlet obstruction include:<ref name="pmid7235767">{{cite journal |vauthors=Bradley EL, Clements JL |title=Idiopathic duodenal obstruction: an unappreciated complication of pancreatitis |journal=Ann. Surg. |volume=193 |issue=5 |pages=638–48 |year=1981 |pmid=7235767 |pmc=1345138 |doi= |url=}}</ref><ref name="pmid1539568">{{cite journal |vauthors=Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK |title=Ingestion of strong corrosive alkalis: spectrum of injury to upper gastrointestinal tract and natural history |journal=Am. J. Gastroenterol. |volume=87 |issue=3 |pages=337–41 |year=1992 |pmid=1539568 |doi= |url=}}</ref><ref name="pmid15332026">{{cite journal |vauthors=Poley JW, Steyerberg EW, Kuipers EJ, Dees J, Hartmans R, Tilanus HW, Siersema PD |title=Ingestion of acid and alkaline agents: outcome and prognostic value of early upper endoscopy |journal=Gastrointest. Endosc. |volume=60 |issue=3 |pages=372–7 |year=2004 |pmid=15332026 |doi= |url=}}</ref><ref name="pmid10079337">{{cite journal |vauthors=Ciftci AO, Senocak ME, Büyükpamukçu N, Hiçsönmez A |title=Gastric outlet obstruction due to corrosive ingestion: incidence and outcome |journal=Pediatr. Surg. Int. |volume=15 |issue=2 |pages=88–91 |year=1999 |pmid=10079337 |doi=10.1007/s003830050523 |url=}}</ref>  
Benign causes of GOO can either be congenital or acquired. The [[Acquired disorder|acquired]] causes of GOO can further be categorized into acute or chronic. The acquired acute causes of GOO results from [[edema]] and [[inflammation]] of [[antrum]] and the [[pylorus]]. The acquired chronic causes of GOO results from intrinsic [[obstruction]] due to [[fibrosis]] and [[scar]] formation. In general, benign causes of GOO include: <ref name="pmid7235767">{{cite journal |vauthors=Bradley EL, Clements JL |title=Idiopathic duodenal obstruction: an unappreciated complication of pancreatitis |journal=Ann. Surg. |volume=193 |issue=5 |pages=638–48 |year=1981 |pmid=7235767 |pmc=1345138 |doi= |url=}}</ref><ref name="pmid1539568">{{cite journal |vauthors=Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK |title=Ingestion of strong corrosive alkalis: spectrum of injury to upper gastrointestinal tract and natural history |journal=Am. J. Gastroenterol. |volume=87 |issue=3 |pages=337–41 |year=1992 |pmid=1539568 |doi= |url=}}</ref><ref name="pmid15332026">{{cite journal |vauthors=Poley JW, Steyerberg EW, Kuipers EJ, Dees J, Hartmans R, Tilanus HW, Siersema PD |title=Ingestion of acid and alkaline agents: outcome and prognostic value of early upper endoscopy |journal=Gastrointest. Endosc. |volume=60 |issue=3 |pages=372–7 |year=2004 |pmid=15332026 |doi= |url=}}</ref><ref name="pmid10079337">{{cite journal |vauthors=Ciftci AO, Senocak ME, Büyükpamukçu N, Hiçsönmez A |title=Gastric outlet obstruction due to corrosive ingestion: incidence and outcome |journal=Pediatr. Surg. Int. |volume=15 |issue=2 |pages=88–91 |year=1999 |pmid=10079337 |doi=10.1007/s003830050523 |url=}}</ref>  
* [[Acute (medicine)|Acute]]- [[edema]] and [[inflammation]]
* [[Chronic (medical)|Chronic]]- due to intrinsic [[obstruction]] as a result of [[fibrosis]] and [[scar]] formation
** [[Peptic ulcer|PUD]]: 5% cases (most commonly affecting [[pylorus]] and initial part of the [[duodenum]])  
** [[Peptic ulcer|PUD]]: 5% cases (most commonly affecting [[pylorus]] and initial part of the [[duodenum]])  
** [[Polyps|Gastric polyps]]<ref name="pmid7129059">{{cite journal |vauthors=Miner PB, Harri JE, McPhee MS |title=Intermittent gastric outlet obstruction from a pedunculated gastric polyp |journal=Gastrointest. Endosc. |volume=28 |issue=3 |pages=219–20 |year=1982 |pmid=7129059 |doi= |url=}}</ref><ref name="pmid12831404">{{cite journal |vauthors=Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Tozun N |title=Antral hyperplastic polyp causing intermittent gastric outlet obstruction: case report |journal=BMC Gastroenterol |volume=3 |issue= |pages=16 |year=2003 |pmid=12831404 |pmc=166166 |doi=10.1186/1471-230X-3-16 |url=}}</ref>  
** [[Polyps|Gastric polyps]]<ref name="pmid7129059">{{cite journal |vauthors=Miner PB, Harri JE, McPhee MS |title=Intermittent gastric outlet obstruction from a pedunculated gastric polyp |journal=Gastrointest. Endosc. |volume=28 |issue=3 |pages=219–20 |year=1982 |pmid=7129059 |doi= |url=}}</ref><ref name="pmid12831404">{{cite journal |vauthors=Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Tozun N |title=Antral hyperplastic polyp causing intermittent gastric outlet obstruction: case report |journal=BMC Gastroenterol |volume=3 |issue= |pages=16 |year=2003 |pmid=12831404 |pmc=166166 |doi=10.1186/1471-230X-3-16 |url=}}</ref>  
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** [[Stenosis|Duodenal stricture]] <ref name="pmid2000520">{{cite journal |vauthors=Taylor SM, Adams DB, Anderson MC |title=Duodenal stricture: a complication of chronic fibrocalcific pancreatitis |journal=South. Med. J. |volume=84 |issue=3 |pages=338–41 |year=1991 |pmid=2000520 |doi= |url=}}</ref>
** [[Stenosis|Duodenal stricture]] <ref name="pmid2000520">{{cite journal |vauthors=Taylor SM, Adams DB, Anderson MC |title=Duodenal stricture: a complication of chronic fibrocalcific pancreatitis |journal=South. Med. J. |volume=84 |issue=3 |pages=338–41 |year=1991 |pmid=2000520 |doi= |url=}}</ref>
** Systemic [[amyloidosis]] of the [[gastrointestinal tract]] <ref name="pmid8331978">{{cite journal |vauthors=Menke DM, Kyle RA, Fleming CR, Wolfe JT, Kurtin PJ, Oldenburg WA |title=Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis |journal=Mayo Clin. Proc. |volume=68 |issue=8 |pages=763–7 |year=1993 |pmid=8331978 |doi= |url=}}</ref><ref name="pmid9891699">{{cite journal |vauthors=Friedman S, Janowitz HD |title=Systemic amyloidosis and the gastrointestinal tract |journal=Gastroenterol. Clin. North Am. |volume=27 |issue=3 |pages=595–614, vi |year=1998 |pmid=9891699 |doi= |url=}}</ref>
** Systemic [[amyloidosis]] of the [[gastrointestinal tract]] <ref name="pmid8331978">{{cite journal |vauthors=Menke DM, Kyle RA, Fleming CR, Wolfe JT, Kurtin PJ, Oldenburg WA |title=Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis |journal=Mayo Clin. Proc. |volume=68 |issue=8 |pages=763–7 |year=1993 |pmid=8331978 |doi= |url=}}</ref><ref name="pmid9891699">{{cite journal |vauthors=Friedman S, Janowitz HD |title=Systemic amyloidosis and the gastrointestinal tract |journal=Gastroenterol. Clin. North Am. |volume=27 |issue=3 |pages=595–614, vi |year=1998 |pmid=9891699 |doi= |url=}}</ref>
** Eosinophillic [[gastroenteritis]] <ref name="pmid10660821">{{cite journal |vauthors=Khan S, Orenstein SR |title=Eosinophilic gastroenteritis masquerading as pyloric stenosis |journal=Clin Pediatr (Phila) |volume=39 |issue=1 |pages=55–7 |year=2000 |pmid=10660821 |doi=10.1177/000992280003900109 |url=}}</ref><ref name="pmid11400803">{{cite journal |vauthors=Chaudhary R, Shrivastava RK, Mukhopadhyay HG, Diwan RN, Das AK |title=Eosinophilic gastritis--an unusual cause of gastric outlet obstruction |journal=Indian J Gastroenterol |volume=20 |issue=3 |pages=110 |year=2001 |pmid=11400803 |doi= |url=}}</ref><ref name="pmid17614041">{{cite journal |vauthors=Tursi A, Rella G, Inchingolo CD, Maiorano M |title=Gastric outlet obstruction due to gastroduodenal eosinophilic gastroenteritis |journal=Endoscopy |volume=39 Suppl 1 |issue= |pages=E184 |year=2007 |pmid=17614041 |doi=10.1055/s-2006-945125 |url=}}</ref><ref name="pmid14669340">{{cite journal |vauthors=Chen MJ, Chu CH, Lin SC, Shih SC, Wang TE |title=Eosinophilic gastroenteritis: clinical experience with 15 patients |journal=World J. Gastroenterol. |volume=9 |issue=12 |pages=2813–6 |year=2003 |pmid=14669340 |pmc=4612059 |doi= |url=}}</ref><ref name="pmid8420276">{{cite journal |vauthors=Lee CM, Changchien CS, Chen PC, Lin DY, Sheen IS, Wang CS, Tai DI, Sheen-Chen SM, Chen WJ, Wu CS |title=Eosinophilic gastroenteritis: 10 years experience |journal=Am. J. Gastroenterol. |volume=88 |issue=1 |pages=70–4 |year=1993 |pmid=8420276 |doi= |url=}}</ref>
** Eosinophillic [[gastroenteritis]] <ref name="pmid10660821">{{cite journal |vauthors=Khan S, Orenstein SR |title=Eosinophilic gastroenteritis masquerading as pyloric stenosis |journal=Clin Pediatr (Phila) |volume=39 |issue=1 |pages=55–7 |year=2000 |pmid=10660821 |doi=10.1177/000992280003900109 |url=}}</ref><ref name="pmid11400803">{{cite journal |vauthors=Chaudhary R, Shrivastava RK, Mukhopadhyay HG, Diwan RN, Das AK |title=Eosinophilic gastritis--an unusual cause of gastric outlet obstruction |journal=Indian J Gastroenterol |volume=20 |issue=3 |pages=110 |year=2001 |pmid=11400803 |doi= |url=}}</ref>
** [[Obstruction]] by [[Gallstone disease|gallstones]] (Bouveret syndrome)  
** [[Obstruction]] by [[Gallstone disease|gallstones]] (Bouveret syndrome)  
** Complication of [[acute pancreatitis]]: [[pancreatic pseudocyst]] formation<ref name="pmid6732492">{{cite journal |vauthors=Aranha GV, Prinz RA, Greenlee HB, Freeark RJ |title=Gastric outlet and duodenal obstruction from inflammatory pancreatic disease |journal=Arch Surg |volume=119 |issue=7 |pages=833–5 |year=1984 |pmid=6732492 |doi= |url=}}</ref><ref name="pmid4811173">{{cite journal |vauthors=Agrawal NM, Gyr N, McDowell W, Font RG |title=Intestinal obstruction due to acute pancreatitis. Case report and review of literature |journal=Am J Dig Dis |volume=19 |issue=2 |pages=179–85 |year=1974 |pmid=4811173 |doi= |url=}}</ref>
** Complication of [[acute pancreatitis]]: [[pancreatic pseudocyst]] formation<ref name="pmid6732492">{{cite journal |vauthors=Aranha GV, Prinz RA, Greenlee HB, Freeark RJ |title=Gastric outlet and duodenal obstruction from inflammatory pancreatic disease |journal=Arch Surg |volume=119 |issue=7 |pages=833–5 |year=1984 |pmid=6732492 |doi= |url=}}</ref><ref name="pmid4811173">{{cite journal |vauthors=Agrawal NM, Gyr N, McDowell W, Font RG |title=Intestinal obstruction due to acute pancreatitis. Case report and review of literature |journal=Am J Dig Dis |volume=19 |issue=2 |pages=179–85 |year=1974 |pmid=4811173 |doi= |url=}}</ref>
** [[Chronic pancreatitis]] <ref name="pmid2658160">{{cite journal |vauthors=Bradley EL |title=Complications of chronic pancreatitis |journal=Surg. Clin. North Am. |volume=69 |issue=3 |pages=481–97 |year=1989 |pmid=2658160 |doi= |url=}}</ref><ref name="pmid19629001">{{cite journal |vauthors=Levenick JM, Gordon SR, Sutton JE, Suriawinata A, Gardner TB |title=A comprehensive, case-based review of groove pancreatitis |journal=Pancreas |volume=38 |issue=6 |pages=e169–75 |year=2009 |pmid=19629001 |doi=10.1097/MPA.0b013e3181ac73f1 |url=}}</ref>  
** [[Chronic pancreatitis]] <ref name="pmid2658160">{{cite journal |vauthors=Bradley EL |title=Complications of chronic pancreatitis |journal=Surg. Clin. North Am. |volume=69 |issue=3 |pages=481–97 |year=1989 |pmid=2658160 |doi= |url=}}</ref>  
** [[Sarcoidosis]] of the [[Gastrointestinal tract|GIT]] <ref name="pmid2180656">{{cite journal |vauthors=Stampfl DA, Grimm IS, Barbot DJ, Rosato FE, Gordon SJ |title=Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations |journal=Dig. Dis. Sci. |volume=35 |issue=4 |pages=526–32 |year=1990 |pmid=2180656 |doi= |url=}}</ref><ref name="pmid807981">{{cite journal |vauthors=Johnson FE, Humbert JR, Kuzela DC, Todd JK, Lilly JR |title=Gastric outlet obstruction due to X-linked chronic granulomatous disease |journal=Surgery |volume=78 |issue=2 |pages=217–23 |year=1975 |pmid=807981 |doi= |url=}}</ref><ref name="pmid6623357">{{cite journal |vauthors=Mulholland MW, Delaney JP, Simmons RL |title=Gastrointestinal complications of chronic granulomatous disease: surgical implications |journal=Surgery |volume=94 |issue=4 |pages=569–75 |year=1983 |pmid=6623357 |doi= |url=}}</ref><ref name="pmid16970572">{{cite journal |vauthors=Huang A, Abbasakoor F, Vaizey CJ |title=Gastrointestinal manifestations of chronic granulomatous disease |journal=Colorectal Dis |volume=8 |issue=8 |pages=637–44 |year=2006 |pmid=16970572 |doi=10.1111/j.1463-1318.2006.01030.x |url=}}</ref>
** [[Sarcoidosis]] of the [[Gastrointestinal tract|GIT]] <ref name="pmid2180656">{{cite journal |vauthors=Stampfl DA, Grimm IS, Barbot DJ, Rosato FE, Gordon SJ |title=Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations |journal=Dig. Dis. Sci. |volume=35 |issue=4 |pages=526–32 |year=1990 |pmid=2180656 |doi= |url=}}</ref><ref name="pmid807981">{{cite journal |vauthors=Johnson FE, Humbert JR, Kuzela DC, Todd JK, Lilly JR |title=Gastric outlet obstruction due to X-linked chronic granulomatous disease |journal=Surgery |volume=78 |issue=2 |pages=217–23 |year=1975 |pmid=807981 |doi= |url=}}</ref>
** [[Bezoar|Bezoars]]<ref name="pmid9291515">{{cite journal |vauthors=Bakken DA, Abramo TJ |title=Gastric lactobezoar: a rare cause of gastric outlet obstruction |journal=Pediatr Emerg Care |volume=13 |issue=4 |pages=264–7 |year=1997 |pmid=9291515 |doi= |url=}}</ref><ref name="pmid10328129">{{cite journal |vauthors=De Backer A, Van Nooten V, Vandenplas Y |title=Huge gastric trichobezoar in a 10-year-old girl: case report with emphasis on endoscopy in diagnosis and therapy |journal=J. Pediatr. Gastroenterol. Nutr. |volume=28 |issue=5 |pages=513–5 |year=1999 |pmid=10328129 |doi= |url=}}</ref><ref name="pmid9663194">{{cite journal |vauthors=Phillips MR, Zaheer S, Drugas GT |title=Gastric trichobezoar: case report and literature review |journal=Mayo Clin. Proc. |volume=73 |issue=7 |pages=653–6 |year=1998 |pmid=9663194 |doi=10.1016/S0025-6196(11)64889-1 |url=}}</ref><ref name="pmid14738689">{{cite journal |vauthors=White NB, Gibbs KE, Goodwin A, Teixeira J |title=Gastric bezoar complicating laparoscopic adjustable gastric banding, and review of literature |journal=Obes Surg |volume=13 |issue=6 |pages=948–50 |year=2003 |pmid=14738689 |doi=10.1381/096089203322618849 |url=}}</ref><ref name="pmid16448609">{{cite journal |vauthors=Zapata R, Castillo F, Córdova A |title=[Gastric food bezoar as a complication of bariatric surgery. Case report and review of the literature] |language=Spanish; Castilian |journal=Gastroenterol Hepatol |volume=29 |issue=2 |pages=77–80 |year=2006 |pmid=16448609 |doi= |url=}}</ref>
** [[Bezoar|Bezoars]]<ref name="pmid9291515">{{cite journal |vauthors=Bakken DA, Abramo TJ |title=Gastric lactobezoar: a rare cause of gastric outlet obstruction |journal=Pediatr Emerg Care |volume=13 |issue=4 |pages=264–7 |year=1997 |pmid=9291515 |doi= |url=}}</ref><ref name="pmid10328129">{{cite journal |vauthors=De Backer A, Van Nooten V, Vandenplas Y |title=Huge gastric trichobezoar in a 10-year-old girl: case report with emphasis on endoscopy in diagnosis and therapy |journal=J. Pediatr. Gastroenterol. Nutr. |volume=28 |issue=5 |pages=513–5 |year=1999 |pmid=10328129 |doi= |url=}}</ref>
** [[Crohn's disease]] involving the [[duodenum]] <ref name="pmid2919581">{{cite journal |vauthors=Nugent FW, Roy MA |title=Duodenal Crohn's disease: an analysis of 89 cases |journal=Am. J. Gastroenterol. |volume=84 |issue=3 |pages=249–54 |year=1989 |pmid=2919581 |doi= |url=}}</ref><ref name="pmid16278730">{{cite journal |vauthors=Kefalas CH |title=Gastroduodenal Crohn's disease |journal=Proc (Bayl Univ Med Cent) |volume=16 |issue=2 |pages=147–51 |year=2003 |pmid=16278730 |pmc=1201000 |doi= |url=}}</ref><ref name="pmid9360875">{{cite journal |vauthors=Matsui T, Hatakeyama S, Ikeda K, Yao T, Takenaka K, Sakurai T |title=Long-term outcome of endoscopic balloon dilation in obstructive gastroduodenal Crohn's disease |journal=Endoscopy |volume=29 |issue=7 |pages=640–5 |year=1997 |pmid=9360875 |doi=10.1055/s-2007-1004271 |url=}}</ref><ref name="pmid6106466">{{cite journal |vauthors=Fitzgibbons TJ, Green G, Silberman H, Eliasoph J, Halls JM, Yellin AE |title=Management of Crohn's disease involving the duodenum, including duodenal cutaneous fistula |journal=Arch Surg |volume=115 |issue=9 |pages=1022–8 |year=1980 |pmid=6106466 |doi= |url=}}</ref>
** [[Crohn's disease]] involving the [[duodenum]] <ref name="pmid2919581">{{cite journal |vauthors=Nugent FW, Roy MA |title=Duodenal Crohn's disease: an analysis of 89 cases |journal=Am. J. Gastroenterol. |volume=84 |issue=3 |pages=249–54 |year=1989 |pmid=2919581 |doi= |url=}}</ref>
**[[Stomach|Gastro]]-[[Duodenum|duodenal]] [[tuberculosis]]<ref name="pmid12703983">{{cite journal |vauthors=Amarapurkar DN, Patel ND, Amarapurkar AD |title=Primary gastric tuberculosis--report of 5 cases |journal=BMC Gastroenterol |volume=3 |issue= |pages=6 |year=2003 |pmid=12703983 |pmc=155648 |doi= |url=}}</ref><ref name="pmid15540690">{{cite journal |vauthors=Rao YG, Pande GK, Sahni P, Chattopadhyay TK |title=Gastroduodenal tuberculosis management guidelines, based on a large experience and a review of the literature |journal=Can J Surg |volume=47 |issue=5 |pages=364–8 |year=2004 |pmid=15540690 |pmc=3211943 |doi= |url=}}</ref><ref name="pmid16217956">{{cite journal |vauthors=Padussis J, Loffredo B, McAneny D |title=Minimally invasive management of obstructive gastroduodenal tuberculosis |journal=Am Surg |volume=71 |issue=8 |pages=698–700 |year=2005 |pmid=16217956 |doi= |url=}}</ref><ref name="pmid8677960">{{cite journal |vauthors=Di Placido R, Pietroletti R, Leardi S, Simi M |title=Primary gastroduodenal tuberculous infection presenting as pyloric outlet obstruction |journal=Am. J. Gastroenterol. |volume=91 |issue=4 |pages=807–8 |year=1996 |pmid=8677960 |doi= |url=}}</ref><ref name="pmid3605037">{{cite journal |vauthors=Subei I, Attar B, Schmitt G, Levendoglu H |title=Primary gastric tuberculosis: a case report and literature review |journal=Am. J. Gastroenterol. |volume=82 |issue=8 |pages=769–72 |year=1987 |pmid=3605037 |doi= |url=}}</ref>
**[[Stomach|Gastro]]-[[Duodenum|duodenal]] [[tuberculosis]]<ref name="pmid12703983">{{cite journal |vauthors=Amarapurkar DN, Patel ND, Amarapurkar AD |title=Primary gastric tuberculosis--report of 5 cases |journal=BMC Gastroenterol |volume=3 |issue= |pages=6 |year=2003 |pmid=12703983 |pmc=155648 |doi= |url=}}</ref><ref name="pmid15540690">{{cite journal |vauthors=Rao YG, Pande GK, Sahni P, Chattopadhyay TK |title=Gastroduodenal tuberculosis management guidelines, based on a large experience and a review of the literature |journal=Can J Surg |volume=47 |issue=5 |pages=364–8 |year=2004 |pmid=15540690 |pmc=3211943 |doi= |url=}}</ref>
Congenital causes of gastric outlet obstruction include:<ref name="pmid18668780">{{cite journal |vauthors=Kreel L, Ellis H |title=Pyloric stenosis in adults: A clinical and radiological study of 100 consecutive patients |journal=Gut |volume=6 |issue=3 |pages=253–61 |year=1965 |pmid=18668780 |pmc=1552275 |doi= |url=}}</ref><ref name="pmid12145672">{{cite journal |vauthors=Gheorghe L, Băncilă I, Gheorghe C, Herlea V, Vasilescu C, Aposteanu G |title=Antro-duodenal tuberculosis causing gastric outlet obstruction--a rare presentation of a protean disease |journal=Rom J Gastroenterol |volume=11 |issue=2 |pages=149–52 |year=2002 |pmid=12145672 |doi= |url=}}</ref>  
Congenital causes of gastric outlet obstruction include:<ref name="pmid18668780">{{cite journal |vauthors=Kreel L, Ellis H |title=Pyloric stenosis in adults: A clinical and radiological study of 100 consecutive patients |journal=Gut |volume=6 |issue=3 |pages=253–61 |year=1965 |pmid=18668780 |pmc=1552275 |doi= |url=}}</ref><ref name="pmid12145672">{{cite journal |vauthors=Gheorghe L, Băncilă I, Gheorghe C, Herlea V, Vasilescu C, Aposteanu G |title=Antro-duodenal tuberculosis causing gastric outlet obstruction--a rare presentation of a protean disease |journal=Rom J Gastroenterol |volume=11 |issue=2 |pages=149–52 |year=2002 |pmid=12145672 |doi= |url=}}</ref>  
* [[Pyloric stenosis]]:
* [[Pyloric stenosis]]:It is due to [[Hypertrophy (medical)|hypertrophy]] of [[Pyloric antrum|pyloric]] [[Smooth muscle|smooth muscles]] (circular). Pyloric stenosis is the most common cause of GOO in children with boys more commonly affected than girls..
** Most common cause in children 
** More common in boys>girls
** Due to [[Hypertrophy (medical)|hypertrophy]] of [[Pyloric antrum|pyloric]] circular [[Smooth muscle|smooth muscles]]
* [[Congenital disorder|Congenital]] [[Duodenum|duodenal]] webs<ref name="pmid10876738">{{cite journal |vauthors=Adebamowo CA, Oduntan O |title=Duodenal web causing gastric outlet obstruction in an adult |journal=West Afr J Med |volume=18 |issue=1 |pages=73–4 |year=1999 |pmid=10876738 |doi= |url=}}</ref>  
* [[Congenital disorder|Congenital]] [[Duodenum|duodenal]] webs<ref name="pmid10876738">{{cite journal |vauthors=Adebamowo CA, Oduntan O |title=Duodenal web causing gastric outlet obstruction in an adult |journal=West Afr J Med |volume=18 |issue=1 |pages=73–4 |year=1999 |pmid=10876738 |doi= |url=}}</ref>  
* [[Annular pancreas]]<ref name="pmid7771437">{{cite journal |vauthors=Urayama S, Kozarek R, Ball T, Brandabur J, Traverso L, Ryan J, Wechter D |title=Presentation and treatment of annular pancreas in an adult population |journal=Am. J. Gastroenterol. |volume=90 |issue=6 |pages=995–9 |year=1995 |pmid=7771437 |doi= |url=}}</ref>  
* [[Annular pancreas]]<ref name="pmid7771437">{{cite journal |vauthors=Urayama S, Kozarek R, Ball T, Brandabur J, Traverso L, Ryan J, Wechter D |title=Presentation and treatment of annular pancreas in an adult population |journal=Am. J. Gastroenterol. |volume=90 |issue=6 |pages=995–9 |year=1995 |pmid=7771437 |doi= |url=}}</ref>  
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{| class="wikitable" style="border: 0px; font-size: 90%; margin: 3px;" align="center"
{| class="wikitable" style="border: 0px; font-size: 90%; margin: 3px;" align="center"
| colspan="13" style="background: #4479BA; text-align: center;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
| colspan="12" style="background: #4479BA; text-align: center;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
|+  
|+  
| rowspan="3" style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Disease'''}}
| rowspan="3" style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Disease'''}}
| rowspan="3" style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Cause'''}}
| colspan="9" style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Symptoms'''}}
| colspan="9" style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Symptoms'''}}
| style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Diagnosis'''}}
| style="background:#4479BA; padding: 5px 5px;" align="center" |{{fontcolor|#FFF|'''Diagnosis'''}}
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| style="padding: 5px 5px; background: #DCDCDC;" | Gastric outlet obstruction (GOO)
| style="padding: 5px 5px; background: #DCDCDC;" | Gastric outlet obstruction (GOO)
|
|
* [[Peptic ulcer|PUD]]: 5% cases (most commonly affecting [[pylorus]] and initial part of the [[duodenum]])
* [[Abdominal pain|Epigastric pain]]
* [[Polyps|Gastric polyps]]
* [[Caustic|Caustic ingestion]]
* [[Stenosis|Duodenal stricture]] 
* Systemic [[amyloidosis]] of the [[gastrointestinal tract]] 
* Eosinophillic [[gastroenteritis]] 
* [[Obstruction]] by [[Gallstone disease|gallstones]] (Bouveret syndrome)
* Complication of [[acute pancreatitis]]: [[pancreatic pseudocyst]] formation
 
* [[Chronic pancreatitis]]
 
* [[Bezoar|Bezoars]]
* [[Crohn's disease]] involving the [[duodenum]] 
* [[Stomach|Gastro]]-[[Duodenum|duodenal]] [[tuberculosis]]
* Pyloric stenosis
|[[Abdominal pain|Epigastric pain]]
|[[Food]]
|[[Food]]
| -
| -
Line 127: Line 100:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Acute gastritis|'''Acute gastritis''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Acute gastritis|'''Acute gastritis''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]''
* [[NSAIDS]]
* [[Corticosteroids]]
* [[Alcohol]]
* Spicy food
* [[Viral infections]]
* [[Crohn's disease]]
* [[Autoimmune diseases]]
* Bile reflux
* [[Cocaine]] use
* Breathing machine or ventilator
* Ingestion of [[corrosive|corrosives]]
|
|
* [[Epigastric pain]]
* [[Epigastric pain]]
Line 157: Line 117:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastritis|'''Chronic gastritis''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastritis|'''Chronic gastritis''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]''
* [[Alcohol]]
* Medications
* [[Autoimmune diseases]]
* Chronic stress
|
|
* [[Epigastric pain]]
* [[Epigastric pain]]
Line 182: Line 136:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Atrophic gastritis|'''Atrophic gastritis''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Atrophic gastritis|'''Atrophic gastritis''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]''
* [[Autoimmune disease]]
|
|
*[[Epigastric pain]]
*[[Epigastric pain]]
Line 207: Line 158:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Crohn's disease|'''Crohn's disease''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Crohn's disease|'''Crohn's disease''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* [[Autoimmune disease]]
|
|
* [[Abdominal pain]]
* [[Abdominal pain]]
Line 222: Line 171:
* [[Rectal bleeding]]
* [[Rectal bleeding]]
|
|
* Mucosal nodularity with cobblestoning
* Multiple [[aphthous ulcers]]
* Linier or serpiginous ulcerations
* Thickened antral folds
* Thickened antral folds
* Antral narrowing
* Antral narrowing
Line 235: Line 181:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[GERD|'''GERD''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[GERD|'''GERD''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* Lower esophageal sphincter abnormalities
* [[Hiatal hernia]]
* Abnormal esophageal contractions
* Prolonged emptying of [[stomach]]
* [[Gastrinoma|Gastrinomas]]
|
|
* [[Epigastric pain]]
* [[Epigastric pain]]
Line 266: Line 206:
* [[Cough|Nocturnal cough]]
* [[Cough|Nocturnal cough]]
* [[Hoarseness]]
* [[Hoarseness]]
Complications
* [[Esophagitis]]
* [[Strictures]]
* Barrette esophagus
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Peptic ulcer disease|'''Peptic ulcer disease''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Peptic ulcer disease|'''Peptic ulcer disease''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]''
* [[Smoking]]
* [[Alcohol]]
* [[Radiation therapy]]
* Medications
* [[Zollinger-Ellison syndrome]]
|
|
* [[Epigastric pain]] sometimes extending to back
* [[Epigastric pain]] sometimes extending to back
Line 300: Line 229:
* [[Melena|Black stools]]
* [[Melena|Black stools]]
|'''Gastric ulcers'''
|'''Gastric ulcers'''
* Discrete mucosal lesions with a punched-out smooth ulcer base with whitish fibrinoid base
* Most [[ulcers]] are at the junction of [[fundus]] and antrum
* Most [[ulcers]] are at the junction of [[fundus]] and antrum  
* 0.5-2.5cm
* 0.5-2.5cm
'''Duodenal ulcers'''
'''Duodenal ulcers'''
* Well-demarcated break in the [[mucosa]] that may extend into the [[muscularis propria]] of the [[duodenum]]
* Found in the first part of [[duodenum]]
* Found in the first part of [[duodenum]]
* <1cm
* <1cm
Line 313: Line 240:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastrinoma|'''Gastrinoma''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastrinoma|'''Gastrinoma''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* Associated with [[MEN type 1]]
|
|
* [[Abdominal pain]]
* [[Abdominal pain]]
Line 330: Line 255:
|Useful in collecting the tissue for [[biopsy]]
|Useful in collecting the tissue for [[biopsy]]
|
|
* May present with symptoms of [[GERD]] or [[peptic ulcer disease]]
* Associated with [[MEN type 1]]
'''Diagnostic tests'''
'''Diagnostic tests'''
* Serum [[gastrin]] levels
* Serum [[gastrin]] levels
Line 338: Line 261:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastric Cancer|'''Gastric Adenocarcinoma''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastric Cancer|'''Gastric Adenocarcinoma''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]'' infection
* Smoked and salted food
|
|
* [[Abdominal pain]]
* [[Abdominal pain]]
Line 353: Line 273:
* [[Melena|Black stools]], or blood in stools
* [[Melena|Black stools]], or blood in stools
|'''Esophagogastroduodenoscopy'''
|'''Esophagogastroduodenoscopy'''
* Multiple biopsies are taken to establish the diagnosis
* Multiple biopsies are taken to establish the diagnosis and determine histological variant.
|'''Other symptoms'''
|'''Other symptoms'''
* [[Dysphagia]]
* [[Dysphagia]]
Line 360: Line 280:
|-
|-
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastric lymphoma|'''Primary gastric lymphoma''']]
| style="padding: 5px 5px; background: #DCDCDC;" |[[Gastric lymphoma|'''Primary gastric lymphoma''']]
| style="padding: 5px 5px; background: #F5F5F5;" |
* ''[[H. pylori]]'' infection
|
|
* [[Abdominal pain]]
* [[Abdominal pain]]
Line 377: Line 295:
* Painless swollen [[lymph nodes]] in neck and armpit
* Painless swollen [[lymph nodes]] in neck and armpit
* Night sweats
* Night sweats
* [[Fatigue]]
* [[Fever]]
* [[Cough]] or trouble breathing
|}
|}


Revision as of 19:15, 2 February 2018

Gastric outlet obstruction Microchapters

Home

Overview

Classification

Pathophysiology

Causes

Differentiating Gastric outlet obstruction from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Diagnosis

Treatment

Medical Therapy
Surgery

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Sudarshana Datta, MD [2]

Synonyms and keywords: GOO

Overview

Gastric outlet obstruction occurs due to pathologies that cause intrinsic or extrinsic obstruction of the pylorus and antrum. Infiltration, scar formation or inflammation of the gastric outlet leads to intrinsic obstruction, while malignancy of neighboring structures such as the pancreas, gallbladder, liver and duodenum may lead to extrinsic obstruction of the gastric outlet. Common causes of GOO include PUD, gastric polyps, caustic ingestion, duodenal stricture, systemic amyloidosis of the gastrointestinal tract, eosinophillic gastroenteritis and obstruction by gallstones. Five percent of all cases of peptic ulcer disease (which is the most common benign cause of GOO) worldwide, develop gastric outlet obstruction. GOO presents as nausea, vomiting, dehydration, electrolyte abnormalities, weight loss, malnutrition, fullness of epigastrium, early satiety and bloating. Laboratory studies of patients may show hypokalemic hypochloremic metabolic alkalosis which is a characteristic feature due to vomiting. In case of of GOO due to suspected PUD, tests for H pylori should also be performed in patients. Barium upper GI studies help in the determination of site of obstruction, visualization of the gastric silhouette, presence of gastric dilation, pylorus narrowing, presence of ulcers, tumors and differentiation from gastroparesis. Upper endoscopy performed in patients may help with visualization of the gastric outlet, biopsy sampling in case of intraluminal pathology and thereby helps rule out the presence of malignancy in patients with symptoms of Peptic Ulcer Disease (PUD). Surgery is the primary modality of treatment for patients with GOO. It is required for more than 75 percent of patients, with scarring, fibrosis and tumors. The aims of surgery in case of GOO include relief of obstruction, relief in patients with failure to respond to medical therapy or failure to improve even after 72 hours of therapy and correction of PUD symptoms. Various types of surgical procedures performed in cases of GOO are vagotomy and antrectomy, gastrojejunostomy (vagotomy and antrectomy with Billroth II reconstruction), balloon dilatation, pylorotomy, pyloroplasty and laparoscopic techniques. Care must be taken to look out for various complications arising after surgery such as perforation, anastomotic leak, dilation and dysmotility of stomach, edema of the gastric wall and postgastrectomy syndromes.

Classification

Gastric outlet obstruction (GOO) can be due to any underlying condition that results in mechanical obstruction to emptying of gastric contents. GOO may be classified based on the underlying cause into Benign GOO and malignant GOO. Statistically, benign GOO comprises of 37 percent of cases and includes peptic ulcer disease whereas malignant GOO comprises of 53 percent of cases.

Pathophysiology

It is understood that GOO is the result of multiple intrinsic (lumen & wall) or extrinsic (neighbouring structures) pathologies that involve the antrum and the pylorus.

  • Intrinsic obstruction: Conditions involving infiltration, scar formation or inflammation of antrum and the pylorus may lead to intrinsic obstruction and GOO.
  • Extrinsic obstruction: Any malignancy of neighboring structures such as duodenum, liver, gallbladder and pancreas may lead to extrinsic obstruction of gastric outlet.

Causes

Causes of GOO may be classified as benign and malignant.

Benign causes

Benign causes of GOO can either be congenital or acquired. The acquired causes of GOO can further be categorized into acute or chronic. The acquired acute causes of GOO results from edema and inflammation of antrum and the pylorus. The acquired chronic causes of GOO results from intrinsic obstruction due to fibrosis and scar formation. In general, benign causes of GOO include: [1][2][3][4]

Congenital causes of gastric outlet obstruction include:[23][24]

Malignant causes

Differentiating Gastric outlet obstruction from Other Diseases

Differential Diagnosis
Disease Symptoms Diagnosis Other findings
Pain Nausea & Vomiting Heartburn Belching or Bloating Weight loss Loss of Appetite Stools Endoscopy findings
Location Aggravating Factors Alleviating Factors
Gastric outlet obstruction (GOO) Food - ✔ ✔ ✔ ✔ ✔ Black stools in case of Peptic Ulcer Disease(PUD)

Sodium chloride load test

Needle-guided biopsy

Acute gastritis Food Antacids ✔ ✔ ✔ - ✔ Black stools -
Chronic gastritis Food Antacids ✔ ✔ ✔ ✔ ✔ - H. pylori gastritis

Lymphocytic gastritis

  • Enlarged folds
  • Aphthoid erosions
 -
Atrophic gastritis - - ✔ - ✔ ✔ - H. pylori

Autoimmune

Crohn's disease - - - - - ✔ ✔
  • Thickened antral folds
  • Antral narrowing
  • Hypoperistalsis
  • Duodenal strictures
GERD
  • Spicy food
  • Tight fitting clothing
 ✔

(Suspect delayed gastric emptying)

✔ - - - - Other symptoms:
Peptic ulcer disease

Duodenal ulcer

  • Pain aggravates with empty stomach

Gastric ulcer

  • Pain aggravates with food
  • Pain alleviates with food
 ✔ ✔ - - - Gastric ulcers
  • Most ulcers are at the junction of fundus and antrum
  • 0.5-2.5cm

Duodenal ulcers

  • Found in the first part of duodenum
  • <1cm
 Other diagnostic tests
Gastrinoma - - ✔

(suspect gastric outlet obstruction)

✔ - - - Useful in collecting the tissue for biopsy

Diagnostic tests

Gastric Adenocarcinoma - - ✔ ✔ ✔ ✔ ✔ Esophagogastroduodenoscopy
  • Multiple biopsies are taken to establish the diagnosis and determine histological variant.
 Other symptoms
Primary gastric lymphoma - - - - - ✔ - - Useful in collecting the tissue for biopsy Other symptoms
  • Painless swollen lymph nodes in neck and armpit
  • Night sweats

Epidemiology and Demographics

The epidemiology of GOO is as follows:[43][44]

Diagnosis

History and Symptoms

The following history is relevant in patients with GOO:[45][46]

The clinical presentation of GOO is as follows:

Early stages:[5][26]

Late stages:[29][28][47][48]

Physical Examination

In the late stages of GOO, patients may develop signs of malnutrition and incomplete obstruction.

{{#ev:youtube|UVJYQlUm2A8}}

Laboratory Findings

Laboratory investigations in patients may reveal the following findings:

Imaging Findings

Imaging studies such as plain radiographs, contrast upper gastrointestinal (GI) studies and Computed Tomography (CT) with oral contrast may be used for evaluating patients with symptoms of GOO.

Plain radiographs

Contrast upper gastrointestinal (GI) studies (Gastrografin or barium)

Computed tomography (CT) with oral contrast

Other Diagnostic Studies

Endoscopy

Sodium chloride load test

Needle-guided biopsy

Treatment

Medical Therapy

Surgery

Surgery is the primary modality of treatment for patients with GOO. It is required for more than 75 percent of patients, with scarring, fibrosis and tumors. The aims of surgery in case of GOO include:

  • Relief of obstruction
  • Relief in patients with failure to respond to medical therapy or failure to improve even after 72 hours of therapy
  • Correction of PUD symptoms

Preoperative evaluation

Preoperative evaluation of patients include:

Guidelines for surgery

The following points need to be considered by surgeons:

Types of surgical procedures

The types of surgical procedures performed in cases of GOO are as follows:[20][77][78][79][80][81][82]

Contraindications to surgery

Contraindications to surgery include the following conditions:

Complications of surgery

Complications arising after surgery include:[105][106]

References

  1. ↑ Bradley EL, Clements JL (1981). "Idiopathic duodenal obstruction: an unappreciated complication of pancreatitis". Ann. Surg. 193 (5): 638–48. PMC 1345138. PMID 7235767.
  2. ↑ Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK (1992). "Ingestion of strong corrosive alkalis: spectrum of injury to upper gastrointestinal tract and natural history". Am. J. Gastroenterol. 87 (3): 337–41. PMID 1539568.
  3. ↑ Poley JW, Steyerberg EW, Kuipers EJ, Dees J, Hartmans R, Tilanus HW, Siersema PD (2004). "Ingestion of acid and alkaline agents: outcome and prognostic value of early upper endoscopy". Gastrointest. Endosc. 60 (3): 372–7. PMID 15332026.
  4. ↑ Ciftci AO, Senocak ME, Büyükpamukçu N, Hiçsönmez A (1999). "Gastric outlet obstruction due to corrosive ingestion: incidence and outcome". Pediatr. Surg. Int. 15 (2): 88–91. doi:10.1007/s003830050523. PMID 10079337.
  5. ↑ 5.0 5.1 Miner PB, Harri JE, McPhee MS (1982). "Intermittent gastric outlet obstruction from a pedunculated gastric polyp". Gastrointest. Endosc. 28 (3): 219–20. PMID 7129059.
  6. ↑ Gencosmanoglu R, Sen-Oran E, Kurtkaya-Yapicier O, Tozun N (2003). "Antral hyperplastic polyp causing intermittent gastric outlet obstruction: case report". BMC Gastroenterol. 3: 16. doi:10.1186/1471-230X-3-16. PMC 166166. PMID 12831404.
  7. ↑ Zargar SA, Kochhar R, Nagi B, Mehta S, Mehta SK (1989). "Ingestion of corrosive acids. Spectrum of injury to upper gastrointestinal tract and natural history". Gastroenterology. 97 (3): 702–7. PMID 2753330.
  8. ↑ Taylor SM, Adams DB, Anderson MC (1991). "Duodenal stricture: a complication of chronic fibrocalcific pancreatitis". South. Med. J. 84 (3): 338–41. PMID 2000520.
  9. ↑ Menke DM, Kyle RA, Fleming CR, Wolfe JT, Kurtin PJ, Oldenburg WA (1993). "Symptomatic gastric amyloidosis in patients with primary systemic amyloidosis". Mayo Clin. Proc. 68 (8): 763–7. PMID 8331978.
  10. ↑ Friedman S, Janowitz HD (1998). "Systemic amyloidosis and the gastrointestinal tract". Gastroenterol. Clin. North Am. 27 (3): 595–614, vi. PMID 9891699.
  11. ↑ Khan S, Orenstein SR (2000). "Eosinophilic gastroenteritis masquerading as pyloric stenosis". Clin Pediatr (Phila). 39 (1): 55–7. doi:10.1177/000992280003900109. PMID 10660821.
  12. ↑ Chaudhary R, Shrivastava RK, Mukhopadhyay HG, Diwan RN, Das AK (2001). "Eosinophilic gastritis--an unusual cause of gastric outlet obstruction". Indian J Gastroenterol. 20 (3): 110. PMID 11400803.
  13. ↑ Aranha GV, Prinz RA, Greenlee HB, Freeark RJ (1984). "Gastric outlet and duodenal obstruction from inflammatory pancreatic disease". Arch Surg. 119 (7): 833–5. PMID 6732492.
  14. ↑ Agrawal NM, Gyr N, McDowell W, Font RG (1974). "Intestinal obstruction due to acute pancreatitis. Case report and review of literature". Am J Dig Dis. 19 (2): 179–85. PMID 4811173.
  15. ↑ Bradley EL (1989). "Complications of chronic pancreatitis". Surg. Clin. North Am. 69 (3): 481–97. PMID 2658160.
  16. ↑ Stampfl DA, Grimm IS, Barbot DJ, Rosato FE, Gordon SJ (1990). "Sarcoidosis causing duodenal obstruction. Case report and review of gastrointestinal manifestations". Dig. Dis. Sci. 35 (4): 526–32. PMID 2180656.
  17. ↑ Johnson FE, Humbert JR, Kuzela DC, Todd JK, Lilly JR (1975). "Gastric outlet obstruction due to X-linked chronic granulomatous disease". Surgery. 78 (2): 217–23. PMID 807981.
  18. ↑ Bakken DA, Abramo TJ (1997). "Gastric lactobezoar: a rare cause of gastric outlet obstruction". Pediatr Emerg Care. 13 (4): 264–7. PMID 9291515.
  19. ↑ De Backer A, Van Nooten V, Vandenplas Y (1999). "Huge gastric trichobezoar in a 10-year-old girl: case report with emphasis on endoscopy in diagnosis and therapy". J. Pediatr. Gastroenterol. Nutr. 28 (5): 513–5. PMID 10328129.
  20. ↑ 20.0 20.1 Nugent FW, Roy MA (1989). "Duodenal Crohn's disease: an analysis of 89 cases". Am. J. Gastroenterol. 84 (3): 249–54. PMID 2919581.
  21. ↑ Amarapurkar DN, Patel ND, Amarapurkar AD (2003). "Primary gastric tuberculosis--report of 5 cases". BMC Gastroenterol. 3: 6. PMC 155648. PMID 12703983.
  22. ↑ Rao YG, Pande GK, Sahni P, Chattopadhyay TK (2004). "Gastroduodenal tuberculosis management guidelines, based on a large experience and a review of the literature". Can J Surg. 47 (5): 364–8. PMC 3211943. PMID 15540690.
  23. ↑ Kreel L, Ellis H (1965). "Pyloric stenosis in adults: A clinical and radiological study of 100 consecutive patients". Gut. 6 (3): 253–61. PMC 1552275. PMID 18668780.
  24. ↑ Gheorghe L, Băncilă I, Gheorghe C, Herlea V, Vasilescu C, Aposteanu G (2002). "Antro-duodenal tuberculosis causing gastric outlet obstruction--a rare presentation of a protean disease". Rom J Gastroenterol. 11 (2): 149–52. PMID 12145672.
  25. ↑ Adebamowo CA, Oduntan O (1999). "Duodenal web causing gastric outlet obstruction in an adult". West Afr J Med. 18 (1): 73–4. PMID 10876738.
  26. ↑ 26.0 26.1 Urayama S, Kozarek R, Ball T, Brandabur J, Traverso L, Ryan J, Wechter D (1995). "Presentation and treatment of annular pancreas in an adult population". Am. J. Gastroenterol. 90 (6): 995–9. PMID 7771437.
  27. ↑ Johnson CD (1995). "Gastric outlet obstruction malignant until proved otherwise". Am. J. Gastroenterol. 90 (10): 1740. PMID 7572886.
  28. ↑ 28.0 28.1 28.2 Shone DN, Nikoomanesh P, Smith-Meek MM, Bender JS (1995). "Malignancy is the most common cause of gastric outlet obstruction in the era of H2 blockers". Am. J. Gastroenterol. 90 (10): 1769–70. PMID 7572891.
  29. ↑ 29.0 29.1 Johnson CD, Ellis H (1990). "Gastric outlet obstruction now predicts malignancy". Br J Surg. 77 (9): 1023–4. PMID 2207566.
  30. ↑ Tendler DA (2002). "Malignant gastric outlet obstruction: bridging another divide". Am. J. Gastroenterol. 97 (1): 4–6. doi:10.1111/j.1572-0241.2002.05391.x. PMID 11808968.
  31. ↑ Jeong HY, Yang HW, Seo SW, Seong JK, Na BK, Lee BS, Song GS, Park HS, Lee HY (2002). "Adenocarcinoma arising from an ectopic pancreas in the stomach". Endoscopy. 34 (12): 1014–7. doi:10.1055/s-2002-35836. PMID 12471549.
  32. ↑ Emerson L, Layfield LJ, Rohr LR, Dayton MT (2004). "Adenocarcinoma arising in association with gastric heterotopic pancreas: A case report and review of the literature". J Surg Oncol. 87 (1): 53–7. doi:10.1002/jso.20087. PMID 15221920.
  33. ↑ Roy PK, Venzon DJ, Shojamanesh H, Abou-Saif A, Peghini P, Doppman JL, Gibril F, Jensen RT (2000). "Zollinger-Ellison syndrome. Clinical presentation in 261 patients". Medicine (Baltimore). 79 (6): 379–411. PMID 11144036.
  34. ↑ Sugimachi K, Inokuchi K, Kuwano H, Ooiwa T (1984). "Acute gastritis clinically classified in accordance with data from both upper GI series and endoscopy". Scand J Gastroenterol. 19 (1): 31–7. PMID 6710074.
  35. ↑ Sipponen P, Maaroos HI (2015). "Chronic gastritis". Scand J Gastroenterol. 50 (6): 657–67. doi:10.3109/00365521.2015.1019918. PMC 4673514. PMID 25901896.
  36. ↑ Sartor RB (2006). "Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis". Nat Clin Pract Gastroenterol Hepatol. 3 (7): 390–407. doi:10.1038/ncpgasthep0528. PMID 16819502.
  37. ↑ Sipponen P (1989). "Atrophic gastritis as a premalignant condition". Ann Med. 21 (4): 287–90. PMID 2789799.
  38. ↑ Badillo R, Francis D (2014). "Diagnosis and treatment of gastroesophageal reflux disease". World J Gastrointest Pharmacol Ther. 5 (3): 105–12. doi:10.4292/wjgpt.v5.i3.105. PMC 4133436. PMID 25133039.
  39. ↑ Ramakrishnan K, Salinas RC (2007). "Peptic ulcer disease". Am Fam Physician. 76 (7): 1005–12. PMID 17956071.
  40. ↑ Banasch M, Schmitz F (2007). "Diagnosis and treatment of gastrinoma in the era of proton pump inhibitors". Wien Klin Wochenschr. 119 (19–20): 573–8. doi:10.1007/s00508-007-0884-2. PMID 17985090.
  41. ↑ Dicken BJ, Bigam DL, Cass C, Mackey JR, Joy AA, Hamilton SM (2005). "Gastric adenocarcinoma: review and considerations for future directions". Ann Surg. 241 (1): 27–39. PMC 1356843. PMID 15621988.
  42. ↑ Ghimire P, Wu GY, Zhu L (2011). "Primary gastrointestinal lymphoma". World J Gastroenterol. 17 (6): 697–707. doi:10.3748/wjg.v17.i6.697. PMC 3042647. PMID 21390139.
  43. ↑ Lin KJ, García Rodríguez LA, Hernández-Díaz S (2011). "Systematic review of peptic ulcer disease incidence rates: do studies without validation provide reliable estimates?". Pharmacoepidemiol Drug Saf. 20 (7): 718–28. doi:10.1002/pds.2153. PMID 21626606.
  44. ↑ Sung JJ, Kuipers EJ, El-Serag HB (2009). "Systematic review: the global incidence and prevalence of peptic ulcer disease". Aliment. Pharmacol. Ther. 29 (9): 938–46. doi:10.1111/j.1365-2036.2009.03960.x. PMID 19220208.
  45. ↑ Green ST, Drury JK, McCallion J, Erwin L (1987). "Carcinoid tumour presenting as recurrent gastric outlet obstruction: a case of long-term survival". Scott Med J. 32 (2): 54–5. doi:10.1177/003693308703200212. PMID 3602991.
  46. ↑ Chowdhury A, Dhali GK, Banerjee PK (1996). "Etiology of gastric outlet obstruction". Am. J. Gastroenterol. 91 (8): 1679. PMID 8759707.
  47. ↑ Cappell MS, Davis M (2006). "Characterization of Bouveret's syndrome: a comprehensive review of 128 cases". Am. J. Gastroenterol. 101 (9): 2139–46. doi:10.1111/j.1572-0241.2006.00645.x. PMID 16817848.
  48. ↑ Dubois A, Price SF, Castell DO (1978). "Gastric retention in peptic ulcer disease. A reappraisal". Am J Dig Dis. 23 (11): 993–7. PMID 717362.
  49. ↑ Hangen D, Maltz GS, Anderson JE, Knauer CM (1989). "Marked hypergastrinemia in gastric outlet obstruction". J. Clin. Gastroenterol. 11 (4): 442–4. PMID 2760432.
  50. ↑ Chaudhuri TK, Greenwald AJ, Heading RC (1975). "Measurement of gastric emptying time--a comparative study between nonisotopic aspiration method and new radioisotopic technique". Am J Dig Dis. 20 (11): 1063–6. PMID 1199997.
  51. ↑ Lau JY, Chung SC, Sung JJ, Chan AC, Ng EK, Suen RC, Li AK (1996). "Through-the-scope balloon dilation for pyloric stenosis: long-term results". Gastrointest. Endosc. 43 (2 Pt 1): 98–101. PMID 8635729.
  52. ↑ Awan A, Johnston DE, Jamal MM (1998). "Gastric outlet obstruction with benign endoscopic biopsy should be further explored for malignancy". Gastrointest. Endosc. 48 (5): 497–500. PMID 9831838.
  53. ↑ 53.0 53.1 Goldstein H, Boyle JD (1965). "The saline load test--a bedside evaluation of gastric retention". Gastroenterology. 49 (4): 375–80. PMID 5831782.
  54. ↑ Gouma DJ, van Geenen R, van Gulik T, de Wit LT, Obertop H (1999). "Surgical palliative treatment in bilio-pancreatic malignancy". Ann. Oncol. 10 Suppl 4: 269–72. PMID 10436838.
  55. ↑ Lillemoe KD, Sauter PK, Pitt HA, Yeo CJ, Cameron JL (1993). "Current status of surgical palliation of periampullary carcinoma". Surg Gynecol Obstet. 176 (1): 1–10. PMID 7678945.
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