Barrett's esophagus causes: Difference between revisions
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[[Gastroesophageal reflux disease]] ([[GERD]]) | [[Gastroesophageal reflux disease]] ([[GERD]]) | ||
There are several anatomo-physiologic [[abnormalities]] that may contribute to [[GERD]] <ref>Spechler SJ. Barrett's esophagus. Semin Gastrointest Dis 1996; 7:51.</ref><ref name="pmid8705259">{{cite journal| author=Spechler SJ| title=Barrett's esophagus. | journal=Semin Gastrointest Dis | year= 1996 | volume= 7 | issue= 2 | pages= 51-60 | pmid=8705259 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8705259 }} </ref> | There are several anatomo-physiologic [[abnormalities]] that may contribute to [[GERD]] <ref>Spechler SJ. Barrett's esophagus. Semin Gastrointest Dis 1996; 7:51.</ref><ref name="pmid8705259">{{cite journal| author=Spechler SJ| title=Barrett's esophagus. | journal=Semin Gastrointest Dis | year= 1996 | volume= 7 | issue= 2 | pages= 51-60 | pmid=8705259 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8705259 }} </ref><ref name="pmid4146903">{{cite journal| author=Lavy UI, Funcke AB, van Hell G, Timmerman H| title=Pharmacological properties of ((3alpha-tropanyl)oxy)-5H-benzo(4,5)cycloheptal(1,2-b)-pyridine hydrogen maleate (BS 7723). | journal=Arzneimittelforschung | year= 1973 | volume= 23 | issue= 6 | pages= 854-8 | pmid=4146903 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4146903 }} </ref><ref name="pmid10929625">{{cite journal| author=von Schrenck T| title=[Diagnosis of gastroesophageal reflux and Barrett esophagus]. | journal=Zentralbl Chir | year= 2000 | volume= 125 | issue= 5 | pages= 414-23 | pmid=10929625 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10929625 }} </ref><ref name="pmid28336546">{{cite journal| author=Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R et al.| title=Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux. | journal=Am J Physiol Gastrointest Liver Physiol | year= 2017 | volume= 312 | issue= 6 | pages= G615-G622 | pmid=28336546 | doi=10.1152/ajpgi.00268.2016 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28336546 }} </ref> | ||
* Hypersecretion of [[gastric acid]]. | * Hypersecretion of [[gastric acid]]. | ||
* Decreased [[concentration]] of [[epidermal growth factor]] in salivary secretions. | * Decreased [[concentration]] of [[epidermal growth factor]] in salivary secretions. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]
Overview
Barrett's Oesophagus is commonly caused by Gastroesophageal reflux disease.
Causes
Gastroesophageal reflux disease (GERD)
There are several anatomo-physiologic abnormalities that may contribute to GERD [1][2][3][4][5]
- Hypersecretion of gastric acid.
- Decreased concentration of epidermal growth factor in salivary secretions.
- Diminished esophageal pain sensitivity.
- Poor contraction of the esophagus.
- Decreased muscle tone of the lower esophageal sphincter.
References
- ↑ Spechler SJ. Barrett's esophagus. Semin Gastrointest Dis 1996; 7:51.
- ↑ Spechler SJ (1996). "Barrett's esophagus". Semin Gastrointest Dis. 7 (2): 51–60. PMID 8705259.
- ↑ Lavy UI, Funcke AB, van Hell G, Timmerman H (1973). "Pharmacological properties of ((3alpha-tropanyl)oxy)-5H-benzo(4,5)cycloheptal(1,2-b)-pyridine hydrogen maleate (BS 7723)". Arzneimittelforschung. 23 (6): 854–8. PMID 4146903.
- ↑ von Schrenck T (2000). "[Diagnosis of gastroesophageal reflux and Barrett esophagus]". Zentralbl Chir. 125 (5): 414–23. PMID 10929625.
- ↑ Minacapelli CD, Bajpai M, Geng X, Cheng CL, Chouthai AA, Souza R; et al. (2017). "Barrett's metaplasia develops from cellular reprograming of esophageal squamous epithelium due to gastroesophageal reflux". Am J Physiol Gastrointest Liver Physiol. 312 (6): G615–G622. doi:10.1152/ajpgi.00268.2016. PMID 28336546.