Cystic fibrosis natural history, complications and prognosis: Difference between revisions
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==Complications== | ==Complications== | ||
* In patients with cystic fibrosis the most significant changes are seen in airways. The basic genetic defect causes chronic pulmonary infections with surprisingly few bacterial pathogens. Overall, ''P aeruginosa'' is the most common one, followed by ''S aureus and H influenzae.'' | |||
==Prognosis== | ==Prognosis== | ||
Revision as of 20:06, 9 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: , Shaghayegh Habibi, M.D.[2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History
Malnutrition and poor growth (due to loss of pancreatic exocrine function) leads to death in the first decade of life for most untreated patients.[1]
Complications
- In patients with cystic fibrosis the most significant changes are seen in airways. The basic genetic defect causes chronic pulmonary infections with surprisingly few bacterial pathogens. Overall, P aeruginosa is the most common one, followed by S aureus and H influenzae.
Prognosis
- Life expectancy of patients with cystic fibrosis has been increased over past decades because of better symptomatic treatment strategies.[2]
- In patients with cystic fibrosis, obstructive lung disease and other lung complications are currently the primary causes of morbidity and are responsible for 80% of mortality.[1]
References
- ↑ 1.0 1.1 Cutting GR (2015). "Cystic fibrosis genetics: from molecular understanding to clinical application". Nat. Rev. Genet. 16 (1): 45–56. doi:10.1038/nrg3849. PMC 4364438. PMID 25404111.
- ↑ Ratjen F, Döring G (2003). "Cystic fibrosis". Lancet. 361 (9358): 681–9. doi:10.1016/S0140-6736(03)12567-6. PMID 12606185.