Respiratory acidosis laboratory findings: Difference between revisions
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== Overview == | |||
* Laboratory findings consistent with the diagnosis of respiratory acidosis include Arterial blood gas (ABG) which are helpful in the diagnosis of respiratory acidosis. | |||
== Laboratory Tests == | |||
'''Arterial blood gas (ABG)'''<ref name="pmid20859488">{{cite journal |vauthors=Sood P, Paul G, Puri S |title=Interpretation of arterial blood gas |journal=Indian J Crit Care Med |volume=14 |issue=2 |pages=57–64 |date=April 2010 |pmid=20859488 |pmc=2936733 |doi=10.4103/0972-5229.68215 |url=}}</ref> | |||
* An elevated/reduced concentration in ''Arterial blood gas (ABG)'' is diagnostic of respiratory acidosis. | |||
* Arterial blood gas analysis is vital routine investigation to monitor the acid-base balance of patients with respiratory acidosis. | |||
* '''''Henderson-Hasselbalch equation''''': Used for the bicarbonate level caluculation in the blood gas analysis. | |||
* On ABG analysis pH (< 7.35) is considered as aacidemia. | |||
* When increased partial pressure of arterial carbon dioxide (PaCO<sub>2</sub>) (>45 mm Hg) it is considered as acidemia of respiratory origin. | |||
* Hypoxemia that cause respiratory acidosis is frequently associated with pulmonary diseases. | |||
* Bicarbonate levels are one of the most common abnormal serum electrolyte finding on ABG analysis, Although this feature is nonspecific as other etiologies. | |||
'''Complete blood count(CBC)''' | |||
* Some patients with respiratory acidosis may have polycythemia due to Chronic hypoxemia from underlying lung disease. | |||
* '''''Eosinophilic myalgia''''': Although this condition is rare, An elevated eosinophil count on CBC may be consistent with eosinophilic myalgia. | |||
'''Toxicology screen''' | |||
* Screening for specific drugs should be performed that includes | |||
** Opiates | |||
** Benzodiazepines | |||
** Tricyclic antidepressants | |||
** Barbiturates | |||
'''Thyroid function tests''' | |||
* Some patients with respiratory acidosis may have elevated concentration of thyroid stimulating hormone (TSH) and low thyroxine (T4) , which is usually suggestive of hypothyroidism. | |||
'''Creatine phosphokinase''' | |||
* An elevated concentration of creatine phosphokinase (CPK) is diagnostic of infectious or autoimmune polymyositis rhabdomyolysis which is secondary to colchicine or chloroquine toxicity, or procainamidemyopathy. | |||
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{{Respiratory acidosis}} | {{Respiratory acidosis}} | ||
Revision as of 16:45, 23 February 2018
Overview
- Laboratory findings consistent with the diagnosis of respiratory acidosis include Arterial blood gas (ABG) which are helpful in the diagnosis of respiratory acidosis.
Laboratory Tests
Arterial blood gas (ABG)[1]
- An elevated/reduced concentration in Arterial blood gas (ABG) is diagnostic of respiratory acidosis.
- Arterial blood gas analysis is vital routine investigation to monitor the acid-base balance of patients with respiratory acidosis.
- Henderson-Hasselbalch equation: Used for the bicarbonate level caluculation in the blood gas analysis.
- On ABG analysis pH (< 7.35) is considered as aacidemia.
- When increased partial pressure of arterial carbon dioxide (PaCO2) (>45 mm Hg) it is considered as acidemia of respiratory origin.
- Hypoxemia that cause respiratory acidosis is frequently associated with pulmonary diseases.
- Bicarbonate levels are one of the most common abnormal serum electrolyte finding on ABG analysis, Although this feature is nonspecific as other etiologies.
Complete blood count(CBC)
- Some patients with respiratory acidosis may have polycythemia due to Chronic hypoxemia from underlying lung disease.
- Eosinophilic myalgia: Although this condition is rare, An elevated eosinophil count on CBC may be consistent with eosinophilic myalgia.
Toxicology screen
- Screening for specific drugs should be performed that includes
- Opiates
- Benzodiazepines
- Tricyclic antidepressants
- Barbiturates
Thyroid function tests
- Some patients with respiratory acidosis may have elevated concentration of thyroid stimulating hormone (TSH) and low thyroxine (T4) , which is usually suggestive of hypothyroidism.
Creatine phosphokinase
- An elevated concentration of creatine phosphokinase (CPK) is diagnostic of infectious or autoimmune polymyositis rhabdomyolysis which is secondary to colchicine or chloroquine toxicity, or procainamidemyopathy.
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References
- ↑ Sood P, Paul G, Puri S (April 2010). "Interpretation of arterial blood gas". Indian J Crit Care Med. 14 (2): 57–64. doi:10.4103/0972-5229.68215. PMC 2936733. PMID 20859488.