Respiratory acidosis laboratory findings: Difference between revisions
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== Overview == | == Overview == | ||
* Laboratory findings consistent with the diagnosis of respiratory acidosis include Arterial blood gas (ABG) which are helpful in the | * Laboratory findings consistent with the diagnosis of respiratory acidosis include Arterial blood gas (ABG) which are helpful in the diagnosis of respiratory acidosis. | ||
== Laboratory Tests == | == Laboratory Tests == | ||
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* An elevated/reduced concentration in ''Arterial blood gas (ABG)'' is diagnostic of respiratory acidosis.<ref name="pmid208594882">{{cite journal |vauthors=Sood P, Paul G, Puri S |title=Interpretation of arterial blood gas |journal=Indian J Crit Care Med |volume=14 |issue=2 |pages=57–64 |date=April 2010 |pmid=20859488 |pmc=2936733 |doi=10.4103/0972-5229.68215 |url=}}</ref> | * An elevated/reduced concentration in ''Arterial blood gas (ABG)'' is diagnostic of respiratory acidosis.<ref name="pmid208594882">{{cite journal |vauthors=Sood P, Paul G, Puri S |title=Interpretation of arterial blood gas |journal=Indian J Crit Care Med |volume=14 |issue=2 |pages=57–64 |date=April 2010 |pmid=20859488 |pmc=2936733 |doi=10.4103/0972-5229.68215 |url=}}</ref> | ||
* Arterial blood gas analysis is vital routine investigation to monitor the acid-base balance of patients with respiratory acidosis. | * Arterial blood gas analysis is a vital routine investigation to monitor the acid-base balance of patients with respiratory acidosis. | ||
* '''''Henderson-Hasselbalch equation''''': Used for the bicarbonate | * '''''Henderson-Hasselbalch equation''''': Used for the bicarbonate level calculation in the blood gas analysis. | ||
* On ABG analysis pH (< 7.35) is considered as | * On ABG analysis pH (< 7.35) is considered as academia. | ||
* When increased partial pressure of arterial carbon dioxide (PaCO<sub>2</sub>) (>45 mm Hg) it is considered as acidemia of respiratory origin. | * When increased the partial pressure of arterial carbon dioxide (PaCO<sub>2</sub>) (>45 mm Hg) it is considered as acidemia of respiratory origin. | ||
* | * Hypoxemia that causes respiratory acidosis is frequently associated with pulmonary diseases. | ||
* Bicarbonate levels are one of the most common abnormal serum electrolyte finding on ABG analysis, Although this feature is nonspecific as other etiologies. | * Bicarbonate levels are one of the most common abnormal serum electrolyte finding on ABG analysis, Although this feature is nonspecific as other etiologies. | ||
'''Complete blood count(CBC)''' | '''Complete blood count(CBC)''' |
Revision as of 16:55, 23 February 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
- Laboratory findings consistent with the diagnosis of respiratory acidosis include Arterial blood gas (ABG) which are helpful in the diagnosis of respiratory acidosis.
Laboratory Tests
Arterial blood gas (ABG)[1]
- An elevated/reduced concentration in Arterial blood gas (ABG) is diagnostic of respiratory acidosis.[2]
- Arterial blood gas analysis is a vital routine investigation to monitor the acid-base balance of patients with respiratory acidosis.
- Henderson-Hasselbalch equation: Used for the bicarbonate level calculation in the blood gas analysis.
- On ABG analysis pH (< 7.35) is considered as academia.
- When increased the partial pressure of arterial carbon dioxide (PaCO2) (>45 mm Hg) it is considered as acidemia of respiratory origin.
- Hypoxemia that causes respiratory acidosis is frequently associated with pulmonary diseases.
- Bicarbonate levels are one of the most common abnormal serum electrolyte finding on ABG analysis, Although this feature is nonspecific as other etiologies.
Complete blood count(CBC)
- Some patients with respiratory acidosis may have polycythemia due to Chronic hypoxemia from underlying lung disease.
- Eosinophilic myalgia: Although this condition is rare, An elevated eosinophil count on CBC may be consistent with eosinophilic myalgia.
Toxicology screen
- Screening for specific drugs should be performed that includes
- Opiates
- Benzodiazepines
- Tricyclic antidepressants
- Barbiturates
Thyroid function tests
- Some patients with respiratory acidosis may have elevated concentration of thyroid stimulating hormone (TSH) and low thyroxine (T4) , which is usually suggestive of hypothyroidism.
Creatine phosphokinase
- An elevated concentration of creatine phosphokinase (CPK) is diagnostic of infectious or autoimmune polymyositis rhabdomyolysis which is secondary to colchicine or chloroquine toxicity, or procainamidemyopathy.
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References
- ↑ Sood P, Paul G, Puri S (April 2010). "Interpretation of arterial blood gas". Indian J Crit Care Med. 14 (2): 57–64. doi:10.4103/0972-5229.68215. PMC 2936733. PMID 20859488.
- ↑ Sood P, Paul G, Puri S (April 2010). "Interpretation of arterial blood gas". Indian J Crit Care Med. 14 (2): 57–64. doi:10.4103/0972-5229.68215. PMC 2936733. PMID 20859488.