Respiratory patterns

Respiratory Patterns main page
Overview
Classification Eupnea
Tachypnea
Bradypnea
Apnea
Cheyne-Stokes Respiration
Biot's Respiration
Apneustic Respiration
Agonal Respiration
Kussmaul's Respiration
Sighing Respiration

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Synonyms and keywords:

Eupnea

• Normal breathing is consisted of inhalation (sucking the air into the lungs) followed by exhalation (blowing the air out of the lungs).
• Every exhalation is followed by an automatic pause of about 2 second, before the next inhalation.
• Inhalation is an active process using diaphragm muscles, despite exhalation which is a passive process.
• Eupnea is the normal pattern of breathing with a rate of 10-12 per minute, each cycle is composed of:
  • Inhalation of 1.5-2 seconds
  • Exhalation of 1.5-2 seconds
  • Spontaneous stop of 2 seconds
• The main characteristics of eupnea are as following:
  • Slow
  • Regular
  • Nasal inhalation, oral exhalation
  • Diaphragmatic
  • Effortless
  • Clear auscultation:
    • No panting
    • No wheezing
    • No sighing
    • No deep breathing

Normal respiratory rate in every age group is as following:

Age group	Normal respiratory rate (Breath number per minute)
Infants	30 to 60
1 to 3 years	24 to 40
3 to 6 years	22 to 34
6 to 12 years	18 to 30
12 to 18 years	12 to 16

Tachypnea

• Tachypnea is increased rate and decrease depth of breathing.

The main pathophysiology of tachypnea is as following:

Decreased plasma oxygen (hypoxemia)

Increased plasma CO2 (respiratory acidosis)

Decreased pulmonary compliance

Increased airway resistance

Carotid body

Medullary chemoreceptors

Pulmonary or muscle mechanoreceptors

Airway receptors

Tachypnea

The main causes of tachypnea are classified into pulmonary, cardiovascular, hematologic, and metabolic pathophysiologies.

Causes		Other findings
Pulmonary	Asthma	Wheezing Prolonged Expiration Hyperinflated lungs
	Chronic obstructive pulmonary disease (COPD)	Clear lung field in chest X-ray Flattened diaphragm Hyperinflated lungs
	Pneumonia	Rhonchi and scattered wheezing Air-bronchograms Lobar or interstitial infiltrates
	Congestive heart failure (CHF)	Basilar crackles Jugular vein distention (JVD) Pulmonary edema and congestion
	Pneumothorax	Absent breath sounds Loss of pulmonary and vascular marking
Cardiovascular	Pericardial effusion	Low voltage ECG Pericardial fluid accumulation
	Cardiac Tamponade	Electrical alternans Right ventricular collapse during diastole
	Pulmonary embolism	Sinus tachycardia Right ventricular enlargement McConnell sign in echocardiography
	Myocardial infarct	Inverted T-wave or depressed/elevated ST-segment Local or generalized wall motion abnormality
Hematologic	Anemia	Hypoxemia-induced carotid chemoreceptors stimulation Chronic fatigue and numbness
	Sickle cell disease	Severe bone pain Autosplenectomy Hematuria
Metabolic	Metabolic acidosis	Dyspnea and tachypnea May lead to cardiac arrest and death in severe uncompensated cases
	Diabetic ketoacidosis (DKA)	Abdominal pain and ketonemia High blood glucose

Bradypnea

• Bradypnea is decreased count of breath to less than 8-10 per minute in adults and 16 per minute in infants.
• Mostly in bradypnea the exhalation phase is increased.
• The depth of breathes and tidal volume may be increased during bradypnea episodes.
• The main pathophysiology of bradypnea includes:
  • Desensitization of the medullary responses to PCO₂
  • Reduction in respiratory neuronal activity
  • Inhibition of neural transmission within the respiratory center
  • Neuronal damage to the brain stem
• The main causes of bradypnea are as following:

Causes			Other
Drugs	Opioids	Heroin	Can become worse when used along with: Smoking Benzodiazepines Barbiturates Phenobarbital Gabapentinoids Alcohol consuming Obstructive sleep apnea Chronic obstructive pulmonary disease (COPD) Lung cancer
		Codeine
		Hydrocodone
		Morphine
		Oxycodone
	Toxins	Sodium azide	Found in automobile airbags
		Carbon monoxide	Produced from oil or gas furnaces Absorbed by lungs and decrease the blood oxygen level
	Other drugs	Sedatives	Decrease respiratory drive Desensitizing to lowered plasma oxygen level
		Anesthetics
Systemic disease	Lung diseases	Emphysema	-
		Chronic bronchitis
		Severe asthma
		Pneumonia
		Pulmonary edema
	Thyroid	Hypothyroidism	-
	Neuromuscular	Guillain-Barré syndrome	Affect respiratory nerve and muscles Diaphragm Intercostal muscles
		Amyotrophic lateral sclerosis (ALS)

Apnea

• Apnea is the respiratory arrest for couple of seconds.
• The most common form of apnea in generally healthy people is obstructive sleep apnea.
• The pathophysiology of sleep apnea are as following:

Apnea

Sleep disturbances

↓O2, ↑CO2, ↓pH

Excessive motor activity

Loss of deep sleep Sleep fragmentation

Brain malfunction

Severe CO2 retention

Systemic vasoconstriction

Pulmonary vasoconstriction

Vagal bradycardia Ectopic cardiac pulses

Decreased pulmonary pressure Increased cardiac afterload

Restless sleep

Excessive daytime fatigue

Chronic hypoventilation

Systemic hypertension

Pulmonary hypertension

Unexplained nocturnal death

Left heart failure

Intellectual deterioration

Right heart failure

Personality change

Behavioral disorder

• The main causes of apnea include:
  • Obstructive sleep apnea
  • Opioid toxicity
  • Seizure
  • Asthma
  • Neurologic causes
    • Stroke
    • Myotonic dystrophy
    • Neuromuscular respiratory failure
    • Spinal cord injury
    • Bacterial meningitis
  • Pulmonary causes
    • Chronic obstructive pulmonary disease (COPD)
    • Influenza
    • Pulmonary emboli
    • Aspiration pneumonia
    • Atelectasis
    • Chronic bronchitis
    • Foreign body aspiration
    • Pulmonary edema
    • Viral pneumonia
  • Down syndrome
  • Metabolic acidosis
  • Cannabis use