Sandbox lung cancer differential: Difference between revisions
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* Pulmonary vascular changes in primary tumors are characterized by vascular infiltration, destruction and occlusion whereas in secondary tumors intravascular embolisation and extravasation predominate. | * Pulmonary vascular changes in primary tumors are characterized by vascular infiltration, destruction and occlusion whereas in secondary tumors intravascular embolisation and extravasation predominate. | ||
{| class="wikitable" | {| class="wikitable" | ||
! colspan="4" |Malignant lung carcnimoma | |||
|- | |||
! colspan="2" | | |||
! | ! | ||
! | ! | ||
|- | |||
! | ! colspan="4" |Benign lung carcinoma | ||
|- | |- | ||
| rowspan="4" |Squamous cell carcinoma | | rowspan="4" |Squamous cell carcinoma | ||
| Line 34: | Line 37: | ||
|- | |- | ||
| rowspan="5" |Adeno carcinoma | | rowspan="5" |Adeno carcinoma | ||
|Adenocarcinoma, mixed | |Adenocarcinoma, mixed sub type | ||
| | | | ||
| | | | ||
| Line 46: | Line 49: | ||
| | | | ||
|- | |- | ||
| | |Bronchio-alveolar carcinoma | ||
* | * Non-mucinous | ||
* Mucinous | * Mucinous | ||
* Mixed | * Mixed non-mucinous and mucinous or indeterminate | ||
| | | | ||
| | | | ||
| Line 134: | Line 137: | ||
| | | | ||
|- | |- | ||
| rowspan=" | | rowspan="10" |Mesenchymal tumors | ||
|Epithelioid haemangioendothelioma | |Epithelioid haemangioendothelioma | ||
| | | | ||
| Line 164: | Line 167: | ||
|- | |- | ||
| | | | ||
Synovial sarcoma | Synovial sarcoma | ||
* Monophasic | * Monophasic | ||
| Line 174: | Line 176: | ||
|Pulmonary artery sarcoma | |Pulmonary artery sarcoma | ||
| | | | ||
| | | | ||
|- | |- | ||
| Line 181: | Line 182: | ||
| | | | ||
|- | |- | ||
| colspan="4" |Benign lesions of carcinoma | |||
|- | |||
| rowspan="5" |Papillomas | |||
|Squamous cell papilloma | |||
| | |||
| | |||
|- | |||
| | |||
|Exophytic | |||
| | | | ||
|- | |||
| | |||
|Inverted | |||
| | |||
|- | |||
| | |||
|Glandular papilloma | |||
| | |||
|- | |||
| | |||
|Mixed squamous cell and glandular papilloma | |||
| | |||
|- | |||
| rowspan="6" |Adenomas | |||
|Alveolar adenoma | |||
| | |||
| | |||
|- | |||
| | |||
|Papillary adenoma | |||
| | |||
|- | |||
| | |||
|Adenomas of the salivary gland type | |||
| | |||
|- | |||
| | |||
|Mucous gland adenoma | |||
| | |||
|- | |||
| | |||
|Pleomorphic adenoma | |||
| | |||
|- | |||
| | | | ||
|Others Mucinous cystadenoma | |||
| | | | ||
|} | |} | ||
Revision as of 22:14, 3 March 2018
- Overlapping histologic features differentiation of primary and secondary tumors are difficult.
- Topography, size and form of pulmonary growth pattern are important aspects for the differential diagnosis.
- Primary lung tumors are mainly localized in upper lobes as singular nodules, metastases in lower lobes as multiple lesions.
- On the contarary, endobronchial primary or secondary squamous cell carcinomas findings of severe dysplasia and CIS of the bronchial epithelium are important.
- Stroma and vascularisation pattern of primary and secondary lung tumors differ in distribution, arrangement and extracellular matrix components.
- Pulmonary vascular changes in primary tumors are characterized by vascular infiltration, destruction and occlusion whereas in secondary tumors intravascular embolisation and extravasation predominate.
| Malignant lung carcnimoma | |||
|---|---|---|---|
| Benign lung carcinoma | |||
| Squamous cell carcinoma | Papillary | ||
| Clear cell | |||
| Small cell | |||
| Basaloid | |||
| Small cell carcinoma | Combined small cell carcinoma | ||
| Adeno carcinoma | Adenocarcinoma, mixed sub type | ||
| Acinar adenocarcinoma | |||
| Papillary adenocarcinoma | |||
Bronchio-alveolar carcinoma
|
|||
Solid adenocarcinoma with mucin production
|
|||
| Large cell carcinoma | Giant-cell carcinoma of the lung | ||
| Basaloid large cell carcinoma of the lung | |||
| Clear cell carcinoma of the lung | |||
| Lymphoepithelioma-like carcinoma of the lung | |||
| Large-cell lung carcinoma with rhabdoid phenotype | |||
| Large cell neuroendocrine carcinoma of the lung | |||
| Sarcomatoid carcinoma | Pleomorphic carcinoma
Spindle cell carcinoma Giant cell carcinoma Carcinosarcoma Pulmonary blastoma |
||
| Carcinoid tumour | Typical carcinoid | ||
| Atypical carcinoid | |||
| Salivary gland tumours | Mucoepidermoid carcinoma | ||
| Adenoid cystic carcinoma | |||
| Epithelial-myoepithelial carcinoma | |||
| Preinvasive lesions | Squamous carcinoma in situ | ||
| Atypical adenomatous hyperplasia | |||
| Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia | |||
| Mesenchymal tumors | Epithelioid haemangioendothelioma | ||
| Angiosarcoma | |||
| Pleuropulmonary blastoma | |||
| Chondroma | |||
| Congenital peribronchial myofibroblastic tumor | |||
| Diffuse pulmonary lymphangiomatosis | |||
| Inflammatory myofibroblastic tumor | |||
|
Synovial sarcoma
|
|||
| Pulmonary artery sarcoma | |||
| Pulmonary vein sarcoma | |||
| Benign lesions of carcinoma | |||
| Papillomas | Squamous cell papilloma | ||
| Exophytic | |||
| Inverted | |||
| Glandular papilloma | |||
| Mixed squamous cell and glandular papilloma | |||
| Adenomas | Alveolar adenoma | ||
| Papillary adenoma | |||
| Adenomas of the salivary gland type | |||
| Mucous gland adenoma | |||
| Pleomorphic adenoma | |||
| Others Mucinous cystadenoma | |||