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Computed tomography (CT scan) findings in patients with cystic fibrosis are more sensitive as compared to the pulmonary function tests. It has a crucial role in the assessment of pulmonary damage over time, detecting complications and monitoring treatment.<ref name="pmid271039452">{{cite journal |vauthors=Rybacka A, Karmelita-Katulska K |title=The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis |journal=Pol J Radiol |volume=81 |issue= |pages=141–5 |date=2016 |pmid=27103945 |pmc=4821342 |doi=10.12659/PJR.896051 |url=}}</ref>
Computed tomography (CT scan) findings in patients with cystic fibrosis are more sensitive as compared to the pulmonary function tests. It has a crucial role in the assessment of pulmonary damage over time, detecting complications and monitoring treatment.<ref name="pmid271039452">{{cite journal |vauthors=Rybacka A, Karmelita-Katulska K |title=The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis |journal=Pol J Radiol |volume=81 |issue= |pages=141–5 |date=2016 |pmid=27103945 |pmc=4821342 |doi=10.12659/PJR.896051 |url=}}</ref>


====Chest====
===Chest===
* Mosaic attenuation (localized hyperinflation due to small airway obstruction) on expiratory chest computed tomography (CT) is common in early life cystic fibrosis and often referred to as "air trapping".<ref name="pmid28682006">{{cite journal |vauthors=Rosenow T, Ramsey K, Turkovic L, Murray CP, Mok LC, Hall GL, Stick SM |title=Air trapping in early cystic fibrosis lung disease-Does CT tell the full story? |journal=Pediatr. Pulmonol. |volume=52 |issue=9 |pages=1150–1156 |date=September 2017 |pmid=28682006 |doi=10.1002/ppul.23754 |url=}}</ref>
* Mosaic attenuation (localized hyperinflation due to small airway obstruction) on expiratory chest computed tomography (CT) is common in early life cystic fibrosis and often referred to as "air trapping".<ref name="pmid28682006">{{cite journal |vauthors=Rosenow T, Ramsey K, Turkovic L, Murray CP, Mok LC, Hall GL, Stick SM |title=Air trapping in early cystic fibrosis lung disease-Does CT tell the full story? |journal=Pediatr. Pulmonol. |volume=52 |issue=9 |pages=1150–1156 |date=September 2017 |pmid=28682006 |doi=10.1002/ppul.23754 |url=}}</ref>


* Chest Ct scan in patients with cystic fibrosis can identify a wide range of morphological abnormalities include:<ref name="pmid271039452">{{cite journal |vauthors=Rybacka A, Karmelita-Katulska K |title=The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis |journal=Pol J Radiol |volume=81 |issue= |pages=141–5 |date=2016 |pmid=27103945 |pmc=4821342 |doi=10.12659/PJR.896051 |url=}}</ref>
==== Most common CT scan findings ====
** Bronchiectasis(which is progressive, irreversible and probably the most relevant structural change in cystic fibrosis)
Most common CT scan findings include:<ref name="pmid271039452">{{cite journal |vauthors=Rybacka A, Karmelita-Katulska K |title=The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis |journal=Pol J Radiol |volume=81 |issue= |pages=141–5 |date=2016 |pmid=27103945 |pmc=4821342 |doi=10.12659/PJR.896051 |url=}}</ref>
** Peribronchial thickening
* Bronchiectasis(which is progressive, irreversible and probably the most relevant structural change in cystic fibrosis)
** Mucous plugging
* Peribronchial thickening
* Mucous plugging


** sacculations
==== Less common CT scan findings ====
** Abscesses,
Less common CT scan findings include:
** bullae,
* sacculations
** emphysema,
* Abscesses,
** air trapping,
* bullae,
** hyperinflation,
* emphysema,
** collapse,
* air trapping,
** consolidation,
* hyperinflation,
** mosaic perfusion,
* collapse,
** ground-glass opacities,
* consolidation,
** acinar nodules,
* mosaic perfusion,
** alveolar consolidation
* ground-glass opacities,
** thickening of interlobular and intralobular septa
* acinar nodules,
 
* alveolar consolidation
====Abdomen====
* thickening of interlobular and intralobular septa
===Abdomen===
CT scan of abdomen in patients with cystic fibrosis may include these findings:<ref name="pmid14753605">{{cite journal |vauthors=Carucci LR, Jacobs JE |title=Focal fatty sparing of the pancreatic head in cystic fibrosis: CT findings |journal=Abdom Imaging |volume=28 |issue=6 |pages=853–5 |date=2003 |pmid=14753605 |doi= |url=}}</ref><ref name="pmid9755398">{{cite journal |vauthors=Lugo-Olivieri CH, Soyer PA, Fishman EK |title=Cystic fibrosis: spectrum of thoracic and abdominal CT findings in the adult patient |journal=Clin Imaging |volume=22 |issue=5 |pages=346–54 |date=1998 |pmid=9755398 |doi= |url=}}</ref>
CT scan of abdomen in patients with cystic fibrosis may include these findings:<ref name="pmid14753605">{{cite journal |vauthors=Carucci LR, Jacobs JE |title=Focal fatty sparing of the pancreatic head in cystic fibrosis: CT findings |journal=Abdom Imaging |volume=28 |issue=6 |pages=853–5 |date=2003 |pmid=14753605 |doi= |url=}}</ref><ref name="pmid9755398">{{cite journal |vauthors=Lugo-Olivieri CH, Soyer PA, Fishman EK |title=Cystic fibrosis: spectrum of thoracic and abdominal CT findings in the adult patient |journal=Clin Imaging |volume=22 |issue=5 |pages=346–54 |date=1998 |pmid=9755398 |doi= |url=}}</ref>
* Diffuse and complete fatty replacement of pancreas is the most common imaging appearance.
* Diffuse and complete fatty replacement of pancreas is the most common imaging appearance.
Line 37: Line 39:
* Intestinal findings on CT may include obstruction (more common in children).
* Intestinal findings on CT may include obstruction (more common in children).


====Images====
===Images===
CT demonstrates mucous plugging and complete pancreatic atrophy<ref name="urlCystic fibrosis | Radiology Case | Radiopaedia.org">{{cite web |url=https://radiopaedia.org/cases/cystic-fibrosis-5 |title=Cystic fibrosis &#124; Radiology Case &#124; Radiopaedia.org |format= |work= |accessdate=}}</ref>
CT demonstrates mucous plugging and complete pancreatic atrophy<ref name="urlCystic fibrosis | Radiology Case | Radiopaedia.org">{{cite web |url=https://radiopaedia.org/cases/cystic-fibrosis-5 |title=Cystic fibrosis &#124; Radiology Case &#124; Radiopaedia.org |format= |work= |accessdate=}}</ref>


Revision as of 16:47, 5 March 2018


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]

Overview

CT scan

Computed tomography (CT scan) findings in patients with cystic fibrosis are more sensitive as compared to the pulmonary function tests. It has a crucial role in the assessment of pulmonary damage over time, detecting complications and monitoring treatment.[1]

Chest

  • Mosaic attenuation (localized hyperinflation due to small airway obstruction) on expiratory chest computed tomography (CT) is common in early life cystic fibrosis and often referred to as "air trapping".[2]

Most common CT scan findings

Most common CT scan findings include:[1]

  • Bronchiectasis(which is progressive, irreversible and probably the most relevant structural change in cystic fibrosis)
  • Peribronchial thickening
  • Mucous plugging

Less common CT scan findings

Less common CT scan findings include:

  • sacculations
  • Abscesses,
  • bullae,
  • emphysema,
  • air trapping,
  • hyperinflation,
  • collapse,
  • consolidation,
  • mosaic perfusion,
  • ground-glass opacities,
  • acinar nodules,
  • alveolar consolidation
  • thickening of interlobular and intralobular septa

Abdomen

CT scan of abdomen in patients with cystic fibrosis may include these findings:[3][4]

  • Diffuse and complete fatty replacement of pancreas is the most common imaging appearance.
  • Fibrosis of the pancreas can be detectable on CT scan.
  • Intestinal findings on CT may include obstruction (more common in children).

Images

CT demonstrates mucous plugging and complete pancreatic atrophy[5]

References

  1. ↑ 1.0 1.1 Rybacka A, Karmelita-Katulska K (2016). "The Role of Computed Tomography in Monitoring Patients with Cystic Fibrosis". Pol J Radiol. 81: 141–5. doi:10.12659/PJR.896051. PMC 4821342. PMID 27103945.
  2. ↑ Rosenow T, Ramsey K, Turkovic L, Murray CP, Mok LC, Hall GL, Stick SM (September 2017). "Air trapping in early cystic fibrosis lung disease-Does CT tell the full story?". Pediatr. Pulmonol. 52 (9): 1150–1156. doi:10.1002/ppul.23754. PMID 28682006.
  3. ↑ Carucci LR, Jacobs JE (2003). "Focal fatty sparing of the pancreatic head in cystic fibrosis: CT findings". Abdom Imaging. 28 (6): 853–5. PMID 14753605.
  4. ↑ Lugo-Olivieri CH, Soyer PA, Fishman EK (1998). "Cystic fibrosis: spectrum of thoracic and abdominal CT findings in the adult patient". Clin Imaging. 22 (5): 346–54. PMID 9755398.
  5. ↑ "Cystic fibrosis | Radiology Case | Radiopaedia.org".

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