Neonatal jaundice diagnostic study of choice: Difference between revisions
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* Bilirubin plasma level is the [[Gold standard (test)|gold standard]] test for the diagnosis of jaundice. | * Bilirubin plasma level is the [[Gold standard (test)|gold standard]] test for the diagnosis of jaundice. | ||
* Usually the concentration of [[bilirubin]] in the [[blood]] must exceed 2–3 [[Milligram|mg]]/[[Decilitre|dL]] for the coloration to be easily visible. | * Usually the concentration of [[bilirubin]] in the [[blood]] must exceed 2–3 [[Milligram|mg]]/[[Decilitre|dL]] for the coloration to be easily visible. | ||
*Laboratory findings consistent with the [[diagnosis]] of jaundice include:<ref name="pmid21250253">{{cite journal |vauthors=Walker HK, Hall WD, Hurst JW, Stillman AE |title= |journal= |volume= |issue= |pages= |year= |pmid=21250253 |doi= |url=}}< | *Laboratory findings consistent with the [[diagnosis]] of jaundice include:<ref name="pmid21250253">{{cite journal |vauthors=Walker HK, Hall WD, Hurst JW, Stillman AE |title= |journal= |volume= |issue= |pages= |year= |pmid=21250253 |doi= |url=}}</ref> | ||
**An elevated concentration of serum total [[bilirubin]]. The upper limit of normal is >1 mg/dL or >1.3 mg/d in some laboratories. | **An elevated concentration of serum total [[bilirubin]]. The upper limit of normal is >1 mg/dL or >1.3 mg/d in some laboratories. | ||
**Jaundice usually becomes clinically apparent when the serum total [[bilirubin]] concentration is greater than 2 to 3 mg/dL, but threshold for clinically apparent jaundice may vary among patients. | **Jaundice usually becomes clinically apparent when the serum total [[bilirubin]] concentration is greater than 2 to 3 mg/dL, but threshold for clinically apparent jaundice may vary among patients. | ||
Revision as of 19:57, 6 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Bilirubin plasma level is the gold standard test for the diagnosis of jaundice. Usually the concentration of bilirubin in the blood must exceed 2–3 mg/dL for the coloration to be easily visible.
Diagnostic Study of Choice
Study of choice:
- Bilirubin plasma level is the gold standard test for the diagnosis of jaundice.
- Usually the concentration of bilirubin in the blood must exceed 2–3 mg/dL for the coloration to be easily visible.
- Laboratory findings consistent with the diagnosis of jaundice include:[1]
- An elevated concentration of serum total bilirubin. The upper limit of normal is >1 mg/dL or >1.3 mg/d in some laboratories.
- Jaundice usually becomes clinically apparent when the serum total bilirubin concentration is greater than 2 to 3 mg/dL, but threshold for clinically apparent jaundice may vary among patients.
- Hyperbilirubinemia can be further categorized as conjugated or unconjugated:
- Conjugated hyperbilirubinemia:
- Serum conjugated bilirubin concentration >0.4 mg/dL (6.8 micromol/L).
- Direct bilirubin >1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL (85 micromol/L), or more than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL (85 micromol/L).
- Unconjugated hyperbilirubinemia:
- Conjugated bilirubin is <1 mg/dL (17 micromol/L) if the total bilirubin is <5 mg/dL, or less than 20 percent of the total bilirubin if the total bilirubin is >5 mg/dL (85 micromol/L).
- Conjugated hyperbilirubinemia: