Sjögren's syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

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Causes

Life-threatening Causes

• Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. There are no life-threatening causes of disease name, however complications resulting from untreated disease name is common.
• Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
• [Cause] is a life-threatening cause of [disease].

Common Causes

Sjögren's syndrome may be caused by:

• Viral infection
  • Epstein-Barr virus (EBV)
  • Coxsackie virus
  • Hepatitis C virus
  • Cytomegalovirus (CMV)
  • Human herpesvirus 6 (HHV-6)
  • Retroviruses
    • HTLV-I
    • Human endogenous retrovirus and LTRs
    • HIV
• Genetic factors
  • HLA genes
    • HLA-DQB1*0201 and HLA-DQA1*0501 in Caucasian patients
    • DRB1*0803-DQA1*0103-DQB1*0601 in Han Chinese
    • HLA-DR5 in Greek patients
    • DRB1*0405-DRB4*0101-DQA1*0301-DQB1*0401 in Japanese patients
    • DRB1*15 in Spanish patients
  • Non-HLA genes
    • MBL2
    • FCGR2B
    • LTA
    • TNF
    • NCR3
    • NFKBIA
    • TAP2
    • EBF1
    • PTPN22
    • TNFRSF4
    • IL10

Genetic Causes

• [Disease name] is caused by a mutation in the [gene name] gene.

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	No underlying causes
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

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