Henoch-Schönlein purpura causes: Difference between revisions

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*The causes of the HSP is as follows:<ref name="pmid25072122">{{cite journal |vauthors=Davin JC, Coppo R |title=Henoch-Schönlein purpura nephritis in children |journal=Nat Rev Nephrol |volume=10 |issue=10 |pages=563–73 |date=October 2014 |pmid=25072122 |doi=10.1038/nrneph.2014.126 |url=}}</ref><ref name="pmid25399937">{{cite journal |vauthors=Micheletti RG, Werth VP |title=Small vessel vasculitis of the skin |journal=Rheum. Dis. Clin. North Am. |volume=41 |issue=1 |pages=21–32, vii |date=2015 |pmid=25399937 |doi=10.1016/j.rdc.2014.09.006 |url=}}</ref><ref name="pmid25306598">{{cite journal |vauthors=Zhdanova LV, Patrushev LI, Dolgikh VV, Bimbaev AB, Khoĭkova OCh |title=[The contribution of genes polymorphism of thrombophilia in clinical variability of hemorrhagic vasculitis] |language=Russian |journal=Vestn. Akad. Med. Nauk SSSR |volume= |issue=3-4 |pages=61–4 |date=2014 |pmid=25306598 |doi= |url=}}</ref><ref name="pmid23684700">{{cite journal |vauthors=Rigante D, Castellazzi L, Bosco A, Esposito S |title=Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? |journal=Autoimmun Rev |volume=12 |issue=10 |pages=1016–21 |date=August 2013 |pmid=23684700 |doi=10.1016/j.autrev.2013.04.003 |url=}}</ref><ref name="pmid25688001">{{cite journal |vauthors=Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B |title=IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects |journal=Autoimmun Rev |volume=14 |issue=7 |pages=579–85 |date=July 2015 |pmid=25688001 |doi=10.1016/j.autrev.2015.02.003 |url=}}</ref><ref name="pmid18524107">{{cite journal |vauthors=Pillebout E, Niaudet P |title=[Henoch-Schönlein purpura] |language=French |journal=Rev Prat |volume=58 |issue=5 |pages=507–11 |date=March 2008 |pmid=18524107 |doi= |url=}}</ref>
*The causes of the HSP is as follows:<ref name="pmid25072122">{{cite journal |vauthors=Davin JC, Coppo R |title=Henoch-Schönlein purpura nephritis in children |journal=Nat Rev Nephrol |volume=10 |issue=10 |pages=563–73 |date=October 2014 |pmid=25072122 |doi=10.1038/nrneph.2014.126 |url=}}</ref><ref name="pmid25399937">{{cite journal |vauthors=Micheletti RG, Werth VP |title=Small vessel vasculitis of the skin |journal=Rheum. Dis. Clin. North Am. |volume=41 |issue=1 |pages=21–32, vii |date=2015 |pmid=25399937 |doi=10.1016/j.rdc.2014.09.006 |url=}}</ref><ref name="pmid25306598">{{cite journal |vauthors=Zhdanova LV, Patrushev LI, Dolgikh VV, Bimbaev AB, Khoĭkova OCh |title=[The contribution of genes polymorphism of thrombophilia in clinical variability of hemorrhagic vasculitis] |language=Russian |journal=Vestn. Akad. Med. Nauk SSSR |volume= |issue=3-4 |pages=61–4 |date=2014 |pmid=25306598 |doi= |url=}}</ref><ref name="pmid23684700">{{cite journal |vauthors=Rigante D, Castellazzi L, Bosco A, Esposito S |title=Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? |journal=Autoimmun Rev |volume=12 |issue=10 |pages=1016–21 |date=August 2013 |pmid=23684700 |doi=10.1016/j.autrev.2013.04.003 |url=}}</ref><ref name="pmid25688001">{{cite journal |vauthors=Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B |title=IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects |journal=Autoimmun Rev |volume=14 |issue=7 |pages=579–85 |date=July 2015 |pmid=25688001 |doi=10.1016/j.autrev.2015.02.003 |url=}}</ref><ref name="pmid18524107">{{cite journal |vauthors=Pillebout E, Niaudet P |title=[Henoch-Schönlein purpura] |language=French |journal=Rev Prat |volume=58 |issue=5 |pages=507–11 |date=March 2008 |pmid=18524107 |doi= |url=}}</ref>
*The exact cause of HSP is not clear.  
*The exact cause of HSP is not clear.  
*It may be an inappropriate immune response to triggers such as infection especially upper respiratory infection or an extreme allergic reaction to certain medications, food, insect bites or exposure to cold weather.
*It may be an inappropriate immune response to triggers such as infection especially upper respiratory infection or an allergic reaction to certain medications, food, insect bites or exposure to cold weather.
*'''Common causes'''
**Infections-
**Medications
**Hypersesitivity
**Vaccinations- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.
*'''Rare causes'''
**Genetics- very rarely HSP can occur in twins and within the family
**'''Other triggers''' Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
*In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
*In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
*Allergic reaction to foods may cause HSP.
*Allergic reaction to foods may cause HSP.
*Very rarely HSP can occur in twins and within the family.
*Very rarely HSP can occur in twins and within the family.
*Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
*
*Vaccinations- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.




===Causes by Organ System===
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
{| style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
|-
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dental'''
| '''Dental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Cytarabine]] , [[Deferiprone]], [[Ethacrynic Acid]], [[Oxytetracycline]]
| bgcolor="Beige" | [[Cytarabine]] , [[Deferiprone]], [[Ethacrynic Acid]], [[Oxytetracycline]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige" | No underlying causes
|-
|-
|}
|}

Revision as of 14:42, 2 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

  • The causes of the HSP is as follows:[1][2][3][4][5][6]
  • The exact cause of HSP is not clear.
  • It may be an inappropriate immune response to triggers such as infection especially upper respiratory infection or an allergic reaction to certain medications, food, insect bites or exposure to cold weather.
  • Common causes
    • Infections-
    • Medications
    • Hypersesitivity
    • Vaccinations- certain vaccines can cause HSP such as Typhoid, HBV, Measles, Yellow fever, and Cholera.
  • Rare causes
    • Genetics- very rarely HSP can occur in twins and within the family
    • Other triggers Certain drugs, bacteria, insect bites, viral infections, food, cold weather, and trauma may also cause HSP.
  • In HSP, the antibodies are directed against the blood vessels causing vasculitis, bleeding into the skin leading to a subsequent skin rash.
  • Allergic reaction to foods may cause HSP.
  • Very rarely HSP can occur in twins and within the family.


Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Cytarabine , Deferiprone, Ethacrynic Acid, Oxytetracycline
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

  1. ↑ Davin JC, Coppo R (October 2014). "Henoch-Schönlein purpura nephritis in children". Nat Rev Nephrol. 10 (10): 563–73. doi:10.1038/nrneph.2014.126. PMID 25072122.
  2. ↑ Micheletti RG, Werth VP (2015). "Small vessel vasculitis of the skin". Rheum. Dis. Clin. North Am. 41 (1): 21–32, vii. doi:10.1016/j.rdc.2014.09.006. PMID 25399937.
  3. ↑ Zhdanova LV, Patrushev LI, Dolgikh VV, Bimbaev AB, Khoĭkova O (2014). "[The contribution of genes polymorphism of thrombophilia in clinical variability of hemorrhagic vasculitis]". Vestn. Akad. Med. Nauk SSSR (in Russian) (3–4): 61–4. PMID 25306598. Vancouver style error: initials (help)
  4. ↑ Rigante D, Castellazzi L, Bosco A, Esposito S (August 2013). "Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?". Autoimmun Rev. 12 (10): 1016–21. doi:10.1016/j.autrev.2013.04.003. PMID 23684700.
  5. ↑ Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B (July 2015). "IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects". Autoimmun Rev. 14 (7): 579–85. doi:10.1016/j.autrev.2015.02.003. PMID 25688001.
  6. ↑ Pillebout E, Niaudet P (March 2008). "[Henoch-Schönlein purpura]". Rev Prat (in French). 58 (5): 507–11. PMID 18524107.


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