Rheumatoid arthritis laboratory tests: Difference between revisions
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**Antibodies to citrullinated vimentin and mutated citrullinated vimentin (MCV): | **Antibodies to citrullinated vimentin and mutated citrullinated vimentin (MCV): | ||
***It has specificity of about 90.3–98%, with sensitivity of 69.5–82% | ***It has specificity of about 90.3–98%, with sensitivity of 69.5–82% | ||
{| class="wikitable" | |||
! colspan="4" |The 2010 American College of Rheumatology classification criteria for rheumatoid arthritis. | |||
|- | |||
|'''Domains''' | |||
|'''Description''' | |||
|'''Number''' | |||
|'''Score''' | |||
|- | |||
| rowspan="5" |Joint Involvement | |||
| rowspan="3" |Median-large joint<sup>*</sup> | |||
| | |||
| | |||
|- | |||
|2-10 | |||
|1 | |||
|- | |||
|1-3 | |||
|2 | |||
|- | |||
| rowspan="2" |Small joints | |||
|4-10 | |||
|3 | |||
|- | |||
|>10 | |||
|5 | |||
|- | |||
| rowspan="3" |Serology | |||
|No positive for either RF or anti-CCP | |||
| | |||
|0 | |||
|- | |||
|At least one of these test positive at high titer | |||
| | |||
|2 | |||
|- | |||
|At least one of these test positive at low titer | |||
| | |||
|3 | |||
|- | |||
|Duration of synovitis | |||
| +/> six weeks | |||
| | |||
|1 | |||
|- | |||
| rowspan="2" |Acute phase reactants | |||
|Neither CRP or ESR is abnormal | |||
| | |||
|0 | |||
|- | |||
|Abnormal CRP or ESR | |||
| | |||
|1 | |||
|- | |||
| colspan="4" | | |||
* Distal interphalangeal,1st carpometacapeal and 1st tarsometatarseal joints are excluded from assessment. | |||
|} | |||
==References== | ==References== | ||
Revision as of 17:07, 4 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Following tests are used to make the diagnosis of rheumatoid arthritis:[1][2]
- Complete blood count with differentials
- Acute phase reactant are used to measure disease progression:[3]
- Erythrocyte sedimentation rate
- C-reactive protein: CRP gives an idea about the radiological progression and mean CRP correlates with articular index.
- Renal function test
- Liver function test
- Antibodies
- Rheumatoid factor
- Antibodies to cyclic citrullinated peptides (anti-CCP antibodies):[6]
- It has specificity of about 81-100%, with sensitivity of 39–94%
- Antibodies to citrullinated vimentin and mutated citrullinated vimentin (MCV):
- It has specificity of about 90.3–98%, with sensitivity of 69.5–82%
| The 2010 American College of Rheumatology classification criteria for rheumatoid arthritis. | |||
|---|---|---|---|
| Domains | Description | Number | Score |
| Joint Involvement | Median-large joint* | ||
| 2-10 | 1 | ||
| 1-3 | 2 | ||
| Small joints | 4-10 | 3 | |
| >10 | 5 | ||
| Serology | No positive for either RF or anti-CCP | 0 | |
| At least one of these test positive at high titer | 2 | ||
| At least one of these test positive at low titer | 3 | ||
| Duration of synovitis | +/> six weeks | 1 | |
| Acute phase reactants | Neither CRP or ESR is abnormal | 0 | |
| Abnormal CRP or ESR | 1 | ||
| |||
References
- ↑ Bayliss CE, Dawkins RL, Cullity G, Davis RE, Houliston JB (October 1975). "Laboratory diagnosis of rheumatoid arthritis. Prospective study of 85 patients". Ann. Rheum. Dis. 34 (5): 395–402. PMC 1006439. PMID 769705.
- ↑ Wasserman AM (December 2011). "Diagnosis and management of rheumatoid arthritis". Am Fam Physician. 84 (11): 1245–52. PMID 22150658.
- ↑ van Leeuwen MA, van Rijswijk MH, van der Heijde DM, Te Meerman GJ, van Riel PL, Houtman PM, van De Putte LB, Limburg PC (June 1993). "The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: a prospective study during the first three years of the disease". Br. J. Rheumatol. 32 Suppl 3: 9–13. PMID 8508266.
- ↑ Heidari B (2011). "Rheumatoid Arthritis: Early diagnosis and treatment outcomes". Caspian J Intern Med. 2 (1): 161–70. PMC 3766928. PMID 24024009.
- ↑ Dörner T, Egerer K, Feist E, Burmester GR (May 2004). "Rheumatoid factor revisited". Curr Opin Rheumatol. 16 (3): 246–53. PMID 15103252.
- ↑ van Venrooij WJ, Hazes JM, Visser H (November 2002). "Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis". Neth J Med. 60 (10): 383–8. PMID 12607587.