Reactive arthritis natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Natural History

• The symptoms of reactive arthritis usually develop after 1-3 weeks of initial infection (in another part of the body) and start with symptoms such as malaise, fatigue, and fever.
• Majority of the patients have a self limited course with complete healing within 3-12 months.
• If left untreated, patients with reactive arthritis may progress to develop myalgias and joint pain especially in the lower extremities. Over the course of time, patient develops urethritis and conjunctivitis.
• Urethritis presents with dysuria, increased frequency, urgency, and urethral discharge whereas conjunctivitis leads to pain, burning, and tearing sensation in eyes.

Prognosis

• Prognosis is generally good for patients with reactive arthritis.
• Patients who receive treatment have rapid reversal of symptoms.
• Most patients even if left untreated have complete resolution of symptoms within the next 3-12 months.

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