Autoimmune hemolytic anemia classification: Difference between revisions

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Revision as of 16:29, 12 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2]


Category	Features	Subtypes

Warm-antibody type	Accounts for ~75% of cases of autoimmune hemolytic anemia Due to IgG autoantibody Binding occurs optimally at 37 degrees Celsius Extravascular hemolysis (reticuloendothelial system)	Idiopathic Systemic lupus erythematosus Evans' syndrome Chronic lymphocytic leukemia Non-Hodgkin lymphoma Drugs (methyldopa)
Cold-antibody type	Accounts for ~25% of cases of autoimmune hemolytic anemia Due to IgM autoantibody Binding occurs optimally at 4 degrees Celsius Intravascular hemolysis Recognition by the reticuloendothelial system Destruction by macrophages	Cold agglutinin disease Paroxysmal cold hemoglobinuria Mycoplasma infection Malignancy
Mixed warm-antibody and cold-antibody type	Due to IgM subtype Mixed features	Various clinical entities Generally rare

@@ Line 56: / Line 56: @@
 *Generally rare
 |}
-'''Intravascular haemolysis'''<br>
-Red blood cell lysis occurs in the circulation as a result of activation of the [[complement system]] cascade.
-'''Extravascular haemolysis'''<br>
-Red Blood Cells that are coated with antibodies are specifically recognised in the [[reticuloendothelial system]] and destroyed by [[macrophages]].
-===Subtypes===
-*'''[[Warm antibody autoimmune hemolytic anemia]]'''
-:*Idiopathic
-:*[[Systemic lupus erythematosus]]
-:*[[Evans' syndrome]] (antiplatelet antibodies and haemolytic antibodies)
-:*[[Chronic lymphocytic leukemia]]
-:*Drugs ([[methyldopa]])
-*'''Cold antibody autoimmune hemolytic anemia'''
-:*[[Idiopathic cold hemagglutinin syndrome]]
-:*[[Infectious mononucleosis]]
-:*[[Paroxysmal cold hemoglobinuria]] (rare)
-:*[[Lymphoma]]
-*'''Mixed-type autoimmune hemolytic anemia'''
 ==References==