Rheumatoid arthritis laboratory tests: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory tests used to diagnose [[rheumatoid arthritis]] are [[complete blood count]] with differentials, [[erythrocyte sedimentation rate]], [[CRP]], | Laboratory tests used to diagnose [[rheumatoid arthritis]] are [[complete blood count]] with differentials, [[erythrocyte sedimentation rate]], [[CRP]], renal function test, [[LFT]] and [[antibodies]] such as [[rheumatoid factor]], anti-[[CCP]] and anti MCV. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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*[[Liver function tests|Liver function test]] | *[[Liver function tests|Liver function test]] | ||
*[[Antibodies]] | *[[Antibodies]] | ||
**[[Rheumatoid factor]] | **[[Rheumatoid factor]]: | ||
***Rheumatoid factor is an [[autoantibody]], that can be [[IgM]], [[IgG]] or IgA | ***Rheumatoid factor is an [[autoantibody]], that can be [[IgM]], [[IgG]] or IgA | ||
***According to the classification criteria for [[RA]] published by the [[American College of Rheumatology]], it recognizes domains CH2 and CH3 of the Fc segment of human [[IgG]] | ***According to the classification criteria for [[RA]] published by the [[American College of Rheumatology]], it recognizes domains CH2 and CH3 of the Fc segment of human [[IgG]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]
Overview
Laboratory tests used to diagnose rheumatoid arthritis are complete blood count with differentials, erythrocyte sedimentation rate, CRP, renal function test, LFT and antibodies such as rheumatoid factor, anti-CCP and anti MCV.
Laboratory Findings
Following tests are used to make the diagnosis of rheumatoid arthritis:[1][2]
- Complete blood count with differentials
- Acute phase reactant are used to measure disease progression:[3]
- Erythrocyte sedimentation rate
- C-reactive protein: CRP gives an idea about the radiological progression and mean CRP correlates with articular index
- Renal function test
- Liver function test
- Antibodies
- Rheumatoid factor:
- Rheumatoid factor is an autoantibody, that can be IgM, IgG or IgA
- According to the classification criteria for RA published by the American College of Rheumatology, it recognizes domains CH2 and CH3 of the Fc segment of human IgG
- It has mean specificity of 79%, with sensitivity of about 60%[4][5]
- Antibodies to cyclic citrullinated peptides (anti-CCP antibodies):[6][7]
- It has specificity of about 81-100%, with sensitivity of 39–94%
- Antibodies to citrullinated vimentin and mutated citrullinated vimentin (MCV):
- It has specificity of about 90.3–98%, with sensitivity of 69.5–82%
- Rheumatoid factor:
References
- ↑ Bayliss CE, Dawkins RL, Cullity G, Davis RE, Houliston JB (October 1975). "Laboratory diagnosis of rheumatoid arthritis. Prospective study of 85 patients". Ann. Rheum. Dis. 34 (5): 395–402. PMC 1006439. PMID 769705.
- ↑ Wasserman AM (December 2011). "Diagnosis and management of rheumatoid arthritis". Am Fam Physician. 84 (11): 1245–52. PMID 22150658.
- ↑ van Leeuwen MA, van Rijswijk MH, van der Heijde DM, Te Meerman GJ, van Riel PL, Houtman PM, van De Putte LB, Limburg PC (June 1993). "The acute-phase response in relation to radiographic progression in early rheumatoid arthritis: a prospective study during the first three years of the disease". Br. J. Rheumatol. 32 Suppl 3: 9–13. PMID 8508266.
- ↑ Heidari B (2011). "Rheumatoid Arthritis: Early diagnosis and treatment outcomes". Caspian J Intern Med. 2 (1): 161–70. PMC 3766928. PMID 24024009.
- ↑ Dörner T, Egerer K, Feist E, Burmester GR (May 2004). "Rheumatoid factor revisited". Curr Opin Rheumatol. 16 (3): 246–53. PMID 15103252.
- ↑ van Venrooij WJ, Hazes JM, Visser H (November 2002). "Anticitrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis". Neth J Med. 60 (10): 383–8. PMID 12607587.
- ↑ Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, van Venrooij WJ (January 2000). "The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide". Arthritis Rheum. 43 (1): 155–63. doi:10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3. PMID 10643712.