Takayasu's arteritis risk factors: Difference between revisions
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{{Takayasu's arteritis}} | {{Takayasu's arteritis}} | ||
{{CMG}} {{AE}} {{FKH}} | {{CMG}} {{AE}} {{FKH}} | ||
==Overview== | ==Overview== | ||
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Common [[Risk factor|risk factors]] in the development of Takayasu's arteritis include:<ref name="pmid12853590">{{cite journal |vauthors=Weyand CM, Goronzy JJ |title=Medium- and large-vessel vasculitis |journal=N. Engl. J. Med. |volume=349 |issue=2 |pages=160–9 |date=July 2003 |pmid=12853590 |doi=10.1056/NEJMra022694 |url=}}</ref> | Common [[Risk factor|risk factors]] in the development of Takayasu's arteritis include:<ref name="pmid12853590">{{cite journal |vauthors=Weyand CM, Goronzy JJ |title=Medium- and large-vessel vasculitis |journal=N. Engl. J. Med. |volume=349 |issue=2 |pages=160–9 |date=July 2003 |pmid=12853590 |doi=10.1056/NEJMra022694 |url=}}</ref> | ||
* [[Genetics|Genetic]] predisposition | * [[Genetics|Genetic]] predisposition | ||
** [[Genetics|Genetic]] factors''':''' | |||
*** Takayasu arteritis has been associated with different [[Human leukocyte antigen|human leucocyte antigen]] ([[Human leukocyte antigen|HLA]]) [[Allele|alleles]] in different populations. | |||
*** In Japan and Korea there is a clear association with the extended [[haplotype]]: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901. | |||
** [[Immunology|Immunologic]]: | |||
*** Immunohistopathologic examination has shown that the infiltrating cells in [[Aorta|aortic]] tissue mainly consist of [[Natural killer cell|killer cells]], especially gamma delta [[T lymphocytes]]. | |||
** [[Infection|Infectious]] agents: | |||
*** [[Spirochetes]] | |||
*** ''[[Mycobacterium tuberculosis]]'' | |||
*** [[Streptococcal]] organisms | |||
* Female sex | * Female sex | ||
Revision as of 17:09, 1 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farnaz Khalighinejad, MD [2]
Overview
Common risk factors in the development of Takayasu's arteritis include genetic predisposition, female sex, age <40, asian ethnicity.
Risk Factors
Common Risk Factors
Common risk factors in the development of Takayasu's arteritis include:[1]
- Genetic predisposition
- Genetic factors:
- Takayasu arteritis has been associated with different human leucocyte antigen (HLA) alleles in different populations.
- In Japan and Korea there is a clear association with the extended haplotype: HLA B*52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601, DPA1*02-DPB1*0901.
- Immunologic:
- Immunohistopathologic examination has shown that the infiltrating cells in aortic tissue mainly consist of killer cells, especially gamma delta T lymphocytes.
- Infectious agents:
- Genetic factors:
- Female sex
- Age <40
- Asian ethnicity
References
- ↑ Weyand CM, Goronzy JJ (July 2003). "Medium- and large-vessel vasculitis". N. Engl. J. Med. 349 (2): 160–9. doi:10.1056/NEJMra022694. PMID 12853590.