IgA nephropathy epidemiology and demographics: Difference between revisions
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=== Age === | === Age === | ||
*IgA nephropathy may present at any age. Although, it can occur in childhood. | *IgA nephropathy may present at any age. Although, it can occur in childhood. | ||
*IgA | *IgA nephropathy is often found mostly in adult males in the second to third decade of life. | ||
*It is a frequently diagnosed [[glomerular disease]] in both the pediatric and the adult population. | *It is a frequently diagnosed [[glomerular disease]] in both the pediatric and the adult population. | ||
*The median age ranges between 30-40 years. Recently, IgA Nephropathy has shown an increase in [[incidence]] among patients in older age groups.<ref name="pmid15930092">{{cite journal| author=Barratt J, Feehally J| title=IgA nephropathy. | journal=J Am Soc Nephrol | year= 2005 | volume= 16 | issue= 7 | pages= 2088-97 | pmid=15930092 | doi=10.1681/ASN.2005020134 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930092 }} </ref> | *The median age ranges between 30-40 years. Recently, IgA Nephropathy has shown an increase in [[incidence]] among patients in older age groups.<ref name="pmid15930092">{{cite journal| author=Barratt J, Feehally J| title=IgA nephropathy. | journal=J Am Soc Nephrol | year= 2005 | volume= 16 | issue= 7 | pages= 2088-97 | pmid=15930092 | doi=10.1681/ASN.2005020134 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930092 }} </ref> | ||
*Although the classical presentation of IgA nephropathy is [[Hematuria|gross hematuria]] in a young male patient following an [[upper respiratory tract infection]], such findings are in fact only seen in 30-40% of the patients.<ref name="pmid15930092">{{cite journal| author=Barratt J, Feehally J| title=IgA nephropathy. | journal=J Am Soc Nephrol | year= 2005 | volume= 16 | issue= 7 | pages= 2088-97 | pmid=15930092 | doi=10.1681/ASN.2005020134 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930092 }} </ref> Atypical presentations are more common among older patients. | *Although the classical presentation of IgA nephropathy is [[Hematuria|gross hematuria]] in a young male patient following an [[upper respiratory tract infection]], such findings are in fact only seen in 30-40% of the patients.<ref name="pmid15930092">{{cite journal| author=Barratt J, Feehally J| title=IgA nephropathy. | journal=J Am Soc Nephrol | year= 2005 | volume= 16 | issue= 7 | pages= 2088-97 | pmid=15930092 | doi=10.1681/ASN.2005020134 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15930092 }} </ref> Atypical presentations are more common among older patients. | ||
*It is also noteworthy, that some studies have shown incidence of IgA nephropathy in about 3 -16% healthy individuals <ref name="pmid12753320">{{cite journal| author=Suzuki K, Honda K, Tanabe K, Toma H, Nihei H, Yamaguchi Y| title=Incidence of latent mesangial IgA deposition in renal allograft donors in Japan. | journal=Kidney Int | year= 2003 | volume= 63 | issue= 6 | pages= 2286-94 | pmid=12753320 | doi=10.1046/j.1523-1755.63.6s.2.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12753320 }} </ref>. | |||
It is also noteworthy, that some studies have shown incidence of | *The renal biopsy of the healthy individuals showed evidence of immunogenic IgA deposit in the [[Glomeruli|renal glomeruli]] without any evidence of kidney disease or systemic manifestation. | ||
=== Geographical Distribution === | === Geographical Distribution === | ||
IgA nephropathy is highly prevalent in the Pacific Rim in Europe and North America<ref name="pmid15930092" /> and in the far East Asia, namely China and Japan.<ref name="pmid15341669">{{cite journal| author=Hall YN, Fuentes EF, Chertow GM, Olson JL| title=Race/ethnicity and disease severity in IgA nephropathy. | journal=BMC Nephrol | year= 2004 | volume= 5 | issue= | pages= 10 | pmid=15341669 | doi=10.1186/1471-2369-5-10 | pmc=PMC517500 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15341669 }} </ref> | * IgA nephropathy is highly prevalent in the Pacific Rim in Europe and North America<ref name="pmid15930092" /> and in the far East Asia, namely China and Japan.<ref name="pmid15341669">{{cite journal| author=Hall YN, Fuentes EF, Chertow GM, Olson JL| title=Race/ethnicity and disease severity in IgA nephropathy. | journal=BMC Nephrol | year= 2004 | volume= 5 | issue= | pages= 10 | pmid=15341669 | doi=10.1186/1471-2369-5-10 | pmc=PMC517500 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15341669 }} </ref> | ||
==References== | ==References== | ||
Revision as of 20:34, 7 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
Epidemiology and Demographics
Prevalence
- IgA nephropathy is currently the most common cause of primary glomerulonephritis globally. [1]
- IgA nephropathy is the most common primary chronic glomerulonephritis in the developed world.
- IgA nephropathy comprises approximately 10% of all biopsy-proven glomerulonephritis in USA, 20% of those in Europe and 40-50% of those in Asia.[2]
- The kidney biopsies are not routinely performed for all patients with kidney diseases; hence, IgA nephropathy is perhaps under-diagnosed, and its true prevalence remains unknown.
Incidence
- In 2013, the incidence of IgA nephropathy was estimated to be 3.9–4.5 cases per 100,000 individuals in Japan.[3]
Race
- IgA nephropathy is found more commonly in Asians, Caucasians and people of Eastern Europe. It is very rare in Blacks and people of African descent.
Gender
- IgA nephropathy seems to be more common among males with a 2:1 male to female ratio for both children and adults.[4][5]
- The studies from Japan report an equal male to female ratio.[6]
Age
- IgA nephropathy may present at any age. Although, it can occur in childhood.
- IgA nephropathy is often found mostly in adult males in the second to third decade of life.
- It is a frequently diagnosed glomerular disease in both the pediatric and the adult population.
- The median age ranges between 30-40 years. Recently, IgA Nephropathy has shown an increase in incidence among patients in older age groups.[7]
- Although the classical presentation of IgA nephropathy is gross hematuria in a young male patient following an upper respiratory tract infection, such findings are in fact only seen in 30-40% of the patients.[7] Atypical presentations are more common among older patients.
- It is also noteworthy, that some studies have shown incidence of IgA nephropathy in about 3 -16% healthy individuals [8].
- The renal biopsy of the healthy individuals showed evidence of immunogenic IgA deposit in the renal glomeruli without any evidence of kidney disease or systemic manifestation.
Geographical Distribution
- IgA nephropathy is highly prevalent in the Pacific Rim in Europe and North America[7] and in the far East Asia, namely China and Japan.[9]
References
- ↑ Julian BA, Waldo FB, Rifai A, Mestecky J (1988). "IgA nephropathy, the most common glomerulonephritis worldwide. A neglected disease in the United States?". Am J Med. 84 (1): 129–32. PMID 3337116.
- ↑ Haubitz M, Wittke S, Weissinger EM, Walden M, Rupprecht HD, Floege J; et al. (2005). "Urine protein patterns can serve as diagnostic tools in patients with IgA nephropathy". Kidney Int. 67 (6): 2313–20. doi:10.1111/j.1523-1755.2005.00335.x. PMID 15882273.
- ↑ Sasaki, Kotaro; Anderson, Eric; Shankland, Stuart J.; Nicosia, Roberto F. (2013). "Diffuse Proliferative Glomerulonephritis Associated With Cetuximab, an Epidermal Growth Factor Receptor Inhibitor". American Journal of Kidney Diseases. 61 (6): 988–991. doi:10.1053/j.ajkd.2013.01.008. ISSN 0272-6386.
- ↑ Wyatt RJ, Kritchevsky SB, Woodford SY, Miller PM, Roy S, Holland NH; et al. (1995). "IgA nephropathy: long-term prognosis for pediatric patients". J Pediatr. 127 (6): 913–9. PMID 8523188.
- ↑ Wyatt RJ, Julian BA, Baehler RW, Stafford CC, McMorrow RG, Ferguson T; et al. (1998). "Epidemiology of IgA nephropathy in central and eastern Kentucky for the period 1975 through 1994. Central Kentucky Region of the Southeastern United States IgA Nephropathy DATABANK Project". J Am Soc Nephrol. 9 (5): 853–8. PMID 9596083.
- ↑ Feehally J, Cameron JS (2011). "IgA nephropathy: progress before and since Berger". Am J Kidney Dis. 58 (2): 310–9. doi:10.1053/j.ajkd.2011.03.024. PMID 21705126.
- ↑ 7.0 7.1 7.2 Barratt J, Feehally J (2005). "IgA nephropathy". J Am Soc Nephrol. 16 (7): 2088–97. doi:10.1681/ASN.2005020134. PMID 15930092.
- ↑ Suzuki K, Honda K, Tanabe K, Toma H, Nihei H, Yamaguchi Y (2003). "Incidence of latent mesangial IgA deposition in renal allograft donors in Japan". Kidney Int. 63 (6): 2286–94. doi:10.1046/j.1523-1755.63.6s.2.x. PMID 12753320.
- ↑ Hall YN, Fuentes EF, Chertow GM, Olson JL (2004). "Race/ethnicity and disease severity in IgA nephropathy". BMC Nephrol. 5: 10. doi:10.1186/1471-2369-5-10. PMC 517500. PMID 15341669.