Acute tubular necrosis risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
Common risk factors in the development of acute tubular necrosis include any condition that lead to decreased renal perfusion including, recent abdominal and cardiac surgery, marked [[hypovolemia]], [[sepsis]], [[hemorrhagic shock]], severe [[pancreatitis]], chronic [[Kidney|renal]] disease and [[diabetes mellitus]]. Nephrotoxic medications ( eg, [[ACE inhibitor|ACE inhibitors]], [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[Aminoglycoside|aminoglycosides]], radio [[Contrast medium|contrast media]]) can also be a risk for developing acute tubular necrosis. | |||
==Risk Factors== | ==Risk Factors== | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
*Common risk factors in the development of acute tubular necrosis include: | *Common risk factors in the development of acute tubular necrosis include: | ||
** Surgery<ref name="pmid16520155">{{cite journal |vauthors=Wald R, Waikar SS, Liangos O, Pereira BJ, Chertow GM, Jaber BL |title=Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm |journal=J. Vasc. Surg. |volume=43 |issue=3 |pages=460–466; discussion 466 |date=March 2006 |pmid=16520155 |doi=10.1016/j.jvs.2005.11.053 |url=}}</ref><ref name="pmid19406542">{{cite journal |vauthors=Nigwekar SU, Kandula P, Hix JK, Thakar CV |title=Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies |journal=Am. J. Kidney Dis. |volume=54 |issue=3 |pages=413–23 |date=September 2009 |pmid=19406542 |doi=10.1053/j.ajkd.2009.01.267 |url=}}</ref> (eg, | ** [[Surgery]]<ref name="pmid16520155">{{cite journal |vauthors=Wald R, Waikar SS, Liangos O, Pereira BJ, Chertow GM, Jaber BL |title=Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm |journal=J. Vasc. Surg. |volume=43 |issue=3 |pages=460–466; discussion 466 |date=March 2006 |pmid=16520155 |doi=10.1016/j.jvs.2005.11.053 |url=}}</ref><ref name="pmid19406542">{{cite journal |vauthors=Nigwekar SU, Kandula P, Hix JK, Thakar CV |title=Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies |journal=Am. J. Kidney Dis. |volume=54 |issue=3 |pages=413–23 |date=September 2009 |pmid=19406542 |doi=10.1053/j.ajkd.2009.01.267 |url=}}</ref> (eg, abdominal [[aortic aneurysm]] [[surgery]], [[cardiac surgery]]) | ||
** Septic shock<ref name="pmid25795495">{{cite journal |vauthors=Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM |title=Sepsis-associated acute kidney injury |journal=Semin. Nephrol. |volume=35 |issue=1 |pages=2–11 |date=January 2015 |pmid=25795495 |pmc=4507081 |doi=10.1016/j.semnephrol.2015.01.002 |url=}}</ref> | ** [[Sepsis|Septic shock]]<ref name="pmid25795495">{{cite journal |vauthors=Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM |title=Sepsis-associated acute kidney injury |journal=Semin. Nephrol. |volume=35 |issue=1 |pages=2–11 |date=January 2015 |pmid=25795495 |pmc=4507081 |doi=10.1016/j.semnephrol.2015.01.002 |url=}}</ref> | ||
** Hypovolemia | ** [[Hypovolemia]] | ||
** Hemorrhage | ** [[Bleeding|Hemorrhage]] | ||
** Severe acute pancreatitis<ref name="pmid23774848">{{cite journal |vauthors=Petejova N, Martinek A |title=Acute kidney injury following acute pancreatitis: A review |journal=Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub |volume=157 |issue=2 |pages=105–13 |date=June 2013 |pmid=23774848 |doi=10.5507/bp.2013.048 |url=}}</ref> | ** Severe [[acute pancreatitis]]<ref name="pmid23774848">{{cite journal |vauthors=Petejova N, Martinek A |title=Acute kidney injury following acute pancreatitis: A review |journal=Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub |volume=157 |issue=2 |pages=105–13 |date=June 2013 |pmid=23774848 |doi=10.5507/bp.2013.048 |url=}}</ref> | ||
** Drugs:<ref name="pmid26468475">{{cite journal |vauthors=Ghane Shahrbaf F, Assadi F |title=Drug-induced renal disorders |journal=J Renal Inj Prev |volume=4 |issue=3 |pages=57–60 |date=2015 |pmid=26468475 |pmc=4594214 |doi=10.12861/jrip.2015.12 |url=}}</ref><ref name="pmid2681935">{{cite journal |vauthors=Berns AS |title=Nephrotoxicity of contrast media |journal=Kidney Int. |volume=36 |issue=4 |pages=730–40 |date=October 1989 |pmid=2681935 |doi= |url=}}</ref> | ** Drugs:<ref name="pmid26468475">{{cite journal |vauthors=Ghane Shahrbaf F, Assadi F |title=Drug-induced renal disorders |journal=J Renal Inj Prev |volume=4 |issue=3 |pages=57–60 |date=2015 |pmid=26468475 |pmc=4594214 |doi=10.12861/jrip.2015.12 |url=}}</ref><ref name="pmid2681935">{{cite journal |vauthors=Berns AS |title=Nephrotoxicity of contrast media |journal=Kidney Int. |volume=36 |issue=4 |pages=730–40 |date=October 1989 |pmid=2681935 |doi= |url=}}</ref> | ||
*** ACE inhibitors | *** [[ACE inhibitor|ACE inhibitors]] | ||
*** Aminoglycosides | *** [[Aminoglycoside|Aminoglycosides]] | ||
*** NSAIDs | *** [[Non-steroidal anti-inflammatory drug|NSAIDs]] | ||
*** Amphotericin B | *** [[Amphotericin B]] | ||
*** Radio contrast media | *** [[Contrast media|Radio contrast media]] | ||
*** Ethylene glycol poisoning | *** [[Ethylene glycol|Ethylene glycol poisoning]] | ||
*** Antiviral drugs | *** Antiviral drugs | ||
** Profound hypotension | ** Profound [[hypotension]] | ||
** Diabetes mellitus<ref name="pmid22017349">{{cite journal |vauthors=Girman CJ, Kou TD, Brodovicz K, Alexander CM, O'Neill EA, Engel S, Williams-Herman DE, Katz L |title=Risk of acute renal failure in patients with Type 2 diabetes mellitus |journal=Diabet. Med. |volume=29 |issue=5 |pages=614–21 |date=May 2012 |pmid=22017349 |doi=10.1111/j.1464-5491.2011.03498.x |url=}}</ref> | ** [[Diabetes mellitus]]<ref name="pmid22017349">{{cite journal |vauthors=Girman CJ, Kou TD, Brodovicz K, Alexander CM, O'Neill EA, Engel S, Williams-Herman DE, Katz L |title=Risk of acute renal failure in patients with Type 2 diabetes mellitus |journal=Diabet. Med. |volume=29 |issue=5 |pages=614–21 |date=May 2012 |pmid=22017349 |doi=10.1111/j.1464-5491.2011.03498.x |url=}}</ref> | ||
** Malignancy<ref name="pmid21816711">{{cite journal |vauthors=Faiman BM, Mangan P, Spong J, Tariman JD |title=Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board |journal=Clin J Oncol Nurs |volume=15 Suppl |issue= |pages=66–76 |date=August 2011 |pmid=21816711 |pmc=3433942 |doi=10.1188/11.CJON.S1.66-76 |url=}}</ref> ( eg, multiple myeloma) | ** [[Cancer|Malignancy]]<ref name="pmid21816711">{{cite journal |vauthors=Faiman BM, Mangan P, Spong J, Tariman JD |title=Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board |journal=Clin J Oncol Nurs |volume=15 Suppl |issue= |pages=66–76 |date=August 2011 |pmid=21816711 |pmc=3433942 |doi=10.1188/11.CJON.S1.66-76 |url=}}</ref> (eg, [[multiple myeloma]]) | ||
** Congestive heart failure | ** [[Congestive heart failure]] | ||
** Cirrhosis<ref name="pmid12540770">{{cite journal |vauthors=Moreau R, Lebrec D |title=Acute renal failure in patients with cirrhosis: perspectives in the age of MELD |journal=Hepatology |volume=37 |issue=2 |pages=233–43 |date=February 2003 |pmid=12540770 |doi=10.1053/jhep.2003.50084 |url=}}</ref> | ** [[Cirrhosis]]<ref name="pmid12540770">{{cite journal |vauthors=Moreau R, Lebrec D |title=Acute renal failure in patients with cirrhosis: perspectives in the age of MELD |journal=Hepatology |volume=37 |issue=2 |pages=233–43 |date=February 2003 |pmid=12540770 |doi=10.1053/jhep.2003.50084 |url=}}</ref> | ||
** Tissue injury (eg, rhabdomyolysis) | ** Tissue injury (eg, [[rhabdomyolysis]]) | ||
** Chronic | ** Chronic renal disease<ref name="pmid21094997">{{cite journal |vauthors=James MT, Hemmelgarn BR, Wiebe N, Pannu N, Manns BJ, Klarenbach SW, Tonelli M |title=Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study |journal=Lancet |volume=376 |issue=9758 |pages=2096–103 |date=December 2010 |pmid=21094997 |doi=10.1016/S0140-6736(10)61271-8 |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 17:28, 10 May 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
Common risk factors in the development of acute tubular necrosis include any condition that lead to decreased renal perfusion including, recent abdominal and cardiac surgery, marked hypovolemia, sepsis, hemorrhagic shock, severe pancreatitis, chronic renal disease and diabetes mellitus. Nephrotoxic medications ( eg, ACE inhibitors, NSAIDs, aminoglycosides, radio contrast media) can also be a risk for developing acute tubular necrosis.
Risk Factors
Common Risk Factors
- Common risk factors in the development of acute tubular necrosis include:
- Surgery[1][2] (eg, abdominal aortic aneurysm surgery, cardiac surgery)
- Septic shock[3]
- Hypovolemia
- Hemorrhage
- Severe acute pancreatitis[4]
- Drugs:[5][6]
- Profound hypotension
- Diabetes mellitus[7]
- Malignancy[8] (eg, multiple myeloma)
- Congestive heart failure
- Cirrhosis[9]
- Tissue injury (eg, rhabdomyolysis)
- Chronic renal disease[10]
References
- ↑ Wald R, Waikar SS, Liangos O, Pereira BJ, Chertow GM, Jaber BL (March 2006). "Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm". J. Vasc. Surg. 43 (3): 460–466, discussion 466. doi:10.1016/j.jvs.2005.11.053. PMID 16520155.
- ↑ Nigwekar SU, Kandula P, Hix JK, Thakar CV (September 2009). "Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized and observational studies". Am. J. Kidney Dis. 54 (3): 413–23. doi:10.1053/j.ajkd.2009.01.267. PMID 19406542.
- ↑ Alobaidi R, Basu RK, Goldstein SL, Bagshaw SM (January 2015). "Sepsis-associated acute kidney injury". Semin. Nephrol. 35 (1): 2–11. doi:10.1016/j.semnephrol.2015.01.002. PMC 4507081. PMID 25795495.
- ↑ Petejova N, Martinek A (June 2013). "Acute kidney injury following acute pancreatitis: A review". Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 157 (2): 105–13. doi:10.5507/bp.2013.048. PMID 23774848.
- ↑ Ghane Shahrbaf F, Assadi F (2015). "Drug-induced renal disorders". J Renal Inj Prev. 4 (3): 57–60. doi:10.12861/jrip.2015.12. PMC 4594214. PMID 26468475.
- ↑ Berns AS (October 1989). "Nephrotoxicity of contrast media". Kidney Int. 36 (4): 730–40. PMID 2681935.
- ↑ Girman CJ, Kou TD, Brodovicz K, Alexander CM, O'Neill EA, Engel S, Williams-Herman DE, Katz L (May 2012). "Risk of acute renal failure in patients with Type 2 diabetes mellitus". Diabet. Med. 29 (5): 614–21. doi:10.1111/j.1464-5491.2011.03498.x. PMID 22017349.
- ↑ Faiman BM, Mangan P, Spong J, Tariman JD (August 2011). "Renal complications in multiple myeloma and related disorders: survivorship care plan of the International Myeloma Foundation Nurse Leadership Board". Clin J Oncol Nurs. 15 Suppl: 66–76. doi:10.1188/11.CJON.S1.66-76. PMC 3433942. PMID 21816711.
- ↑ Moreau R, Lebrec D (February 2003). "Acute renal failure in patients with cirrhosis: perspectives in the age of MELD". Hepatology. 37 (2): 233–43. doi:10.1053/jhep.2003.50084. PMID 12540770.
- ↑ James MT, Hemmelgarn BR, Wiebe N, Pannu N, Manns BJ, Klarenbach SW, Tonelli M (December 2010). "Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study". Lancet. 376 (9758): 2096–103. doi:10.1016/S0140-6736(10)61271-8. PMID 21094997.