IgA nephropathy laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

• There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.

Laboratory Findings

• There are no specific and sensitive diagnostic laboratory findings associated with IgA nephropathy.
• Some patients with IgA nephropathy may have elevated concentration of serum total IgA.
  • There is not enough evidence of serum total IgA concentration for the measurement of the severity or activity of IgA nephropathy.
• The urinary Immunoglobulins are not distinctive in IgA nephropathy.

Initial Evaluation

1. Assess all patients with biopsy-proven IgA nephropathy for secondary causes to rule out common causes of secondary IgA nephropathy
   1. Viral serologies: HIV, HBV, HCV
   2. Liver function tests
   3. Electrophoresis of serum immunoglobulins
2. Assess the risk of progression and prognosis by the following parameters at diagnosis and at follow-up:
   1. Blood pressure measurement
   2. Serum creatinine to estimate glomerular filtration rate (GFR)
   3. Proteinuria
   4. Pathological features

A kidney biopsy is to be considered only if signs of AKI and macroscopic hematuria persist for at least 5 days since the onset of kidney injury.