Osteosarcoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou[2].

Overview

Common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.

Risk Factors

Common risk factors in development of osteosarcoma are:

• Age and height: data suggest that the risk of osteosarcoma is highest during the teenage "growth spurt." Children with osteosarcoma are usually tall for their age
• Radiation to bones: people who were treated with radiation for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma
• Drugs: past treatment with anticancer drugs called alkylating antineoplastic agents
• Certain bone diseases:

• Paget disease of bone
• Multiple hereditary osteochondromas
• Fibrous dysplasia
• Enchondromtosis

• Inherited cancer syndromes: Genetic diseases that predispose to osteosarcoma are:

• Bloom syndrome
• Diamond-Blackfan anemia
• Familial adenomatous polyposis
• Li-Fraumeni syndrome
• Hereditary retinoblastoma
• Rothmund-Thomson syndrome
• Werner syndrome