Hypokalemia differential diagnosis: Difference between revisions

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Revision as of 18:52, 6 June 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

Differentiating Causes of Hypokalemia

Differentiating the diseases that can cause hypokalemia is as following table:

Diseases		Clinical manifestations								Para−clinical findings					Gold standard	Additional findings
		Symptoms					Physical examination			Para−clinical findings
		Symptoms					Physical examination			Lab Findings			Imaging
		Fatigue	Fever	Urinary symptoms			Blood Pressure	Skin lesions	Edema	ABG	Urinalysis	Other	Ultrasonography	CT scan
		Fatigue	Fever	Polyuria	Oliguria	Nocturia	Blood Pressure	Skin lesions	Edema	ABG	Urinalysis	Other	Ultrasonography	CT scan
Renal and adrenal disorders	Loop diuretic use^[1]	+/−	−	+	−	+/−	↓	−	+	Metabolic alkalosis	↑K	↑Na	−	−	History of medication use	−
	Primary hyperaldosteronism^[2]	+	−	+	−	+	↑	Facial flushing	−	Metabolic alkalosis	↑K, ↓Na	↓PRA, ↑PAC, ↓Na	Unilateral adrenal hyperplasia	Hypodense unilateral adrenal macroadenoma (>1 cm)	PAC:PRA ratio	Mood disturbance, paresthesia, muscle cramps
	Cushing syndrome^[3]	+	+/−	+/−	−	−	↑	Facial plethora, purple striae	+	Metabolic alkalosis	Glucosuria	↑BS	Unilateral adrenal hyperplasia	−	Urinary free cortisol (24−hour)	Dorsicocervical fat pad, obesity, hirsutism
	Hemodialysis^[4]	+/−	+/−	+/−	−	−	Normal	Pustular lesions	−	Metabolic alkalosis	Normal	↓Na	−	−	History	Carpal tunnel syndrome
	Bartter syndrome^[5]	+	−	+	−	+/−	Normal or ↓	−	−	Metabolic alkalosis	↑K, ↑Ca, ↑Cl	−	−	−	Laboratory findings	Mental retardation, sensorineural hearing loss
	Gitelman syndrome^[6]	+	−	+	−	+	Normal	−	−	Metabolic alkalosis	↑K, ↓Ca, ↑Cl	−	−	−	Laboratory findings	Growth retardation, tetany, muscle cramp
	Liddle syndrome^[7]	−	−	+/−	−	−	↑	−	+/−	Metabolic alkalosis	↑K, ↓Na	↓PRA, ↓PAC	−	−	Laboratory findings	Pseudohyperaldosteronism
Gastrointestinal disorders	GI bleeding^[8]	+	−	−	+	−	↓	−	−	Normal	Normal	Anemia	−	−	Clinical findings	Orthostatic hypotension, bradycardia
	Vomiting^[9]	+	−	−	+	−	↓	−	−	Metabolic alkalosis	Cl <20 mEq/L	−	−	−	Clinical findings	Dry mucous membranes, lethargy
	Severe diarrhea^[10]	+	−	−	+	−	↓	−	−	Metabolic alkalosis	K<20 mEq/L	−	−	−	Clinical findings	Dry mucous membranes, lethargy
	Villous adenoma^[11]	+	−	−	+	−	↓	−	−	Normal	K and Cl <20 mEq/L	Anemia	−	−	Colonoscopy	Hematochezia
	VIPoma^[12]	+	+/−	−	+	−	↓	Facial flushing, skin rash	+	Normal	K<20 mEq/L	Stool osmolar gap <50 mOsm/kg	Endoscopic ultrasound for VIPomas of 2−3 mm	Pancreatic VIPomas >3 cm	Laboratory findings	Weight loss
Neuropsychiatric disorders	Primary polydipsia^[13]	−	−	+	−	+	Normal	−	+/−	Normal	↓Urine osmolarity	↓Na	−	−	Water restriction test	Psychosis
	Central diabetes insipidus^[14]	+	−	+	−	+	Normal or ↓	−	−	Normal	↓Urine osmolarity	↑Na	−	−	Water restriction test	Ischemic encephalopathy
	Bulimia nervosa^[15]	−	−	−	+/−	−	Normal or ↓	Asteatotic skin Carotenodermia	−	Normal	↑K, ↓Cl	−	−	−	Psychological interview	Parotid gland enlargement, lanugo−like hair
	Anorexia nervosa^[16]	+	−	−	+/−	−	↓	Xerosis, hair effluvium	−	Normal	↑K, ↓Cl	−	−	−	Psychological interview	Orthostatic hypotension, bradycardia
	Hypokalemic periodic paralysis^[17]	+	−	−	−	+/−	Normal or ↓	−	+/−	Metabolic alkalosis	K<20 mEq/L	Thyrotoxicosis, ↓Mg, ↓Ph	−	−	Laboratory findings	Paralytic episodes, arrhythmias
Systemic diseases	Hypothermia^[18]	−	−	−	+/−	−	Normal	Frostbite	−	Normal	Normal	−	−	−	Clinical findings	Impaired mental state
	Alcoholism^[19]	+	+/−	+	−	+	Normal or ↓	Icterus, caput medusae	+	Metabolic alkalosis	Ketonuria	Anemia	−	−	Clinical findings	Digital clubbing, gynecomastia
	Diabetic ketoacidosis^[20]	+	+/−	+	−	+	↓	Xerosis	−	Metabolic acidosis	Ketonuria	↑Serum ketone, ↑ blood glucose	−	−	Laboratory findings	Dry mucous membranes, shock
	Hypomagnesemia^[21]	+	−	−	+/−	−	Normal	−	+/−	Metabolic alkalosis	−	↓Ca	−	−	Laboratory findings	Trousseau and Chvostek signs
	Burns^[22]	+/−	−	−	+	−	↓	Vesicle and bullae, erythema	+	Normal	−	Acute phase reactant	−	−	Clinical findings	Dehydration
	Cystic fibrosis^[23]	+/−	+/−	−	+/−	−	↓	Early aquagenic skin wrinkling	+/−	Normal	−	−	Pancreatitis	Pulmonary infiltration	Sweat chloride test	Pancreatic insufficiency

References

↑ Bourke E, Delaney V (1994). "Prevention of hypokalemia caused by diuretics". Heart Dis Stroke. 3 (2): 63–7. PMID 8199766.
↑ Wu C, Xin J, Xin M, Zou H, Jing L, Zhu C; et al. (2016). "Hypokalemic myopathy in primary aldosteronism: A case report". Exp Ther Med. 12 (6): 4064–4066. doi:10.3892/etm.2016.3864. PMC 5228118. PMID 28101185.
↑ Torpy DJ, Mullen N, Ilias I, Nieman LK (September 2002). "Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases". Ann. N. Y. Acad. Sci. 970: 134–44. PMID 12381548.
↑ Choi HY, Ha SK (2013). "Potassium balances in maintenance hemodialysis". Electrolyte Blood Press. 11 (1): 9–16. doi:10.5049/EBP.2013.11.1.9. PMC 3741441. PMID 23946760.
↑ Hebert SC (September 2003). "Bartter syndrome". Curr. Opin. Nephrol. Hypertens. 12 (5): 527–32. doi:10.1097/01.mnh.0000088732.87142.43. PMID 12920401.
↑ Knoers NV, Levtchenko EN (2008). "Gitelman syndrome". Orphanet J Rare Dis. 3: 22. doi:10.1186/1750-1172-3-22. PMC 2518128. PMID 18667063.
↑ Tetti M, Monticone S, Burrello J, Matarazzo P, Veglio F, Pasini B, Jeunemaitre X, Mulatero P (March 2018). "Liddle Syndrome: Review of the Literature and Description of a New Case". Int J Mol Sci. 19 (3). doi:10.3390/ijms19030812. PMC 5877673. PMID 29534496.
↑ Asmar A, Mohandas R, Wingo CS (2012). "A physiologic-based approach to the treatment of a patient with hypokalemia". Am J Kidney Dis. 60 (3): 492–7. doi:10.1053/j.ajkd.2012.01.031. PMC 4776048. PMID 22901631.
↑ Cheungpasitporn W, Suksaranjit P, Chanprasert S (February 2012). "Pathophysiology of vomiting-induced hypokalemia and diagnostic approach". Am J Emerg Med. 30 (2): 384. doi:10.1016/j.ajem.2011.10.005. PMID 22169581.
↑ Bazerbachi F, Haffar S, Szarka LA, Wang Z, Prokop LJ, Murad MH, Camilleri M (November 2017). "Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature". Neurogastroenterol. Motil. 29 (11). doi:10.1111/nmo.13120. PMID 28580600.
↑ Sanchez Garcia S, Villarejo Campos P, Manzanares Campillo Mdel C, Gil Rendo A, Muñoz Atienza V, García Santos EP; et al. (2013). "Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome". Can J Gastroenterol. 27 (11): 621–2. PMC 3816940. PMID 24199207.
↑ Krejs GJ (May 1987). "VIPoma syndrome". Am. J. Med. 82 (5B): 37–48. PMID 3035922.
↑ Gill M, McCauley M (2015). "Psychogenic polydipsia: the result, or cause of, deteriorating psychotic symptoms? A case report of the consequences of water intoxication". Case Rep Psychiatry. 2015: 846459. doi:10.1155/2015/846459. PMC 4320790. PMID 25688318.
↑ Nguyen FN, Kar JK, Verduzco-Gutierrez M, Zakaria A (2014). "A case of hypokalemic paralysis in a patient with neurogenic diabetes insipidus". Neurohospitalist. 4 (2): 90–3. doi:10.1177/1941874413495702. PMC 3975788. PMID 24707338.
↑ Rushing JM, Jones LE, Carney CP (2003). "Bulimia Nervosa: A Primary Care Review". Prim Care Companion J Clin Psychiatry. 5 (5): 217–224. PMC 419300. PMID 15213788.
↑ Liang CC, Yeh HC (2011). "Hypokalemic nephropathy in anorexia nervosa". CMAJ. 183 (11): E761. doi:10.1503/cmaj.101790. PMC 3153553. PMID 21670105.
↑ "Hypokalemic periodic paralysis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".
↑ Zydlewski AW, Hasbargen JA (October 1998). "Hypothermia-induced hypokalemia". Mil Med. 163 (10): 719–21. PMID 9795553.
↑ Elisaf M, Liberopoulos E, Bairaktari E, Siamopoulos K (March 2002). "Hypokalaemia in alcoholic patients". Drug Alcohol Rev. 21 (1): 73–6. doi:10.1080/09595230220119282. PMID 12189007.
↑ Davis SM, Maddux AB, Alonso GT, Okada CR, Mourani PM, Maahs DM (2016). "Profound hypokalemia associated with severe diabetic ketoacidosis". Pediatr Diabetes. 17 (1): 61–5. doi:10.1111/pedi.12246. PMC 4896141. PMID 25430801.
↑ Huang CL, Kuo E (October 2007). "Mechanism of hypokalemia in magnesium deficiency". J. Am. Soc. Nephrol. 18 (10): 2649–52. doi:10.1681/ASN.2007070792. PMID 17804670.
↑ Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG (2017). "Burns: Pathophysiology of Systemic Complications and Current Management". J Burn Care Res. 38 (1): e469–e481. doi:10.1097/BCR.0000000000000355. PMC 5214064. PMID 27183443.
↑ Bates CM, Baum M, Quigley R (February 1997). "Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent". J. Am. Soc. Nephrol. 8 (2): 352–5. PMID 9048354.

Template:WH Template:WS

[pmid8199766-1] Bourke E, Delaney V (1994). "Prevention of hypokalemia caused by diuretics". Heart Dis Stroke. 3 (2): 63–7. PMID 8199766.

[pmid28101185-2] Wu C, Xin J, Xin M, Zou H, Jing L, Zhu C; et al. (2016). "Hypokalemic myopathy in primary aldosteronism: A case report". Exp Ther Med. 12 (6): 4064–4066. doi:10.3892/etm.2016.3864. PMC 5228118. PMID 28101185.

[pmid12381548-3] Torpy DJ, Mullen N, Ilias I, Nieman LK (September 2002). "Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases". Ann. N. Y. Acad. Sci. 970: 134–44. PMID 12381548.

[pmid23946760-4] Choi HY, Ha SK (2013). "Potassium balances in maintenance hemodialysis". Electrolyte Blood Press. 11 (1): 9–16. doi:10.5049/EBP.2013.11.1.9. PMC 3741441. PMID 23946760.

[pmid12920401-5] Hebert SC (September 2003). "Bartter syndrome". Curr. Opin. Nephrol. Hypertens. 12 (5): 527–32. doi:10.1097/01.mnh.0000088732.87142.43. PMID 12920401.

[pmid18667063-6] Knoers NV, Levtchenko EN (2008). "Gitelman syndrome". Orphanet J Rare Dis. 3: 22. doi:10.1186/1750-1172-3-22. PMC 2518128. PMID 18667063.

[pmid29534496-7] Tetti M, Monticone S, Burrello J, Matarazzo P, Veglio F, Pasini B, Jeunemaitre X, Mulatero P (March 2018). "Liddle Syndrome: Review of the Literature and Description of a New Case". Int J Mol Sci. 19 (3). doi:10.3390/ijms19030812. PMC 5877673. PMID 29534496.

[pmid22901631-8] Asmar A, Mohandas R, Wingo CS (2012). "A physiologic-based approach to the treatment of a patient with hypokalemia". Am J Kidney Dis. 60 (3): 492–7. doi:10.1053/j.ajkd.2012.01.031. PMC 4776048. PMID 22901631.

[pmid22169581-9] Cheungpasitporn W, Suksaranjit P, Chanprasert S (February 2012). "Pathophysiology of vomiting-induced hypokalemia and diagnostic approach". Am J Emerg Med. 30 (2): 384. doi:10.1016/j.ajem.2011.10.005. PMID 22169581.

[pmid28580600-10] Bazerbachi F, Haffar S, Szarka LA, Wang Z, Prokop LJ, Murad MH, Camilleri M (November 2017). "Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature". Neurogastroenterol. Motil. 29 (11). doi:10.1111/nmo.13120. PMID 28580600.

[pmid24199207-11] Sanchez Garcia S, Villarejo Campos P, Manzanares Campillo Mdel C, Gil Rendo A, Muñoz Atienza V, García Santos EP; et al. (2013). "Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome". Can J Gastroenterol. 27 (11): 621–2. PMC 3816940. PMID 24199207.

[pmid3035922-12] Krejs GJ (May 1987). "VIPoma syndrome". Am. J. Med. 82 (5B): 37–48. PMID 3035922.

[pmid25688318-13] Gill M, McCauley M (2015). "Psychogenic polydipsia: the result, or cause of, deteriorating psychotic symptoms? A case report of the consequences of water intoxication". Case Rep Psychiatry. 2015: 846459. doi:10.1155/2015/846459. PMC 4320790. PMID 25688318.

[pmid24707338-14] Nguyen FN, Kar JK, Verduzco-Gutierrez M, Zakaria A (2014). "A case of hypokalemic paralysis in a patient with neurogenic diabetes insipidus". Neurohospitalist. 4 (2): 90–3. doi:10.1177/1941874413495702. PMC 3975788. PMID 24707338.

[pmid15213788-15] Rushing JM, Jones LE, Carney CP (2003). "Bulimia Nervosa: A Primary Care Review". Prim Care Companion J Clin Psychiatry. 5 (5): 217–224. PMC 419300. PMID 15213788.

[pmid21670105-16] Liang CC, Yeh HC (2011). "Hypokalemic nephropathy in anorexia nervosa". CMAJ. 183 (11): E761. doi:10.1503/cmaj.101790. PMC 3153553. PMID 21670105.

[urlHypokalemic_periodic_paralysis_|_Genetic_and_Rare_Diseases_Information_Center_(GARD)_–_an_NCATS_Program-17] "Hypokalemic periodic paralysis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program".

[pmid9795553-18] Zydlewski AW, Hasbargen JA (October 1998). "Hypothermia-induced hypokalemia". Mil Med. 163 (10): 719–21. PMID 9795553.

[pmid12189007-19] Elisaf M, Liberopoulos E, Bairaktari E, Siamopoulos K (March 2002). "Hypokalaemia in alcoholic patients". Drug Alcohol Rev. 21 (1): 73–6. doi:10.1080/09595230220119282. PMID 12189007.

[pmid25430801-20] Davis SM, Maddux AB, Alonso GT, Okada CR, Mourani PM, Maahs DM (2016). "Profound hypokalemia associated with severe diabetic ketoacidosis". Pediatr Diabetes. 17 (1): 61–5. doi:10.1111/pedi.12246. PMC 4896141. PMID 25430801.

[pmid17804670-21] Huang CL, Kuo E (October 2007). "Mechanism of hypokalemia in magnesium deficiency". J. Am. Soc. Nephrol. 18 (10): 2649–52. doi:10.1681/ASN.2007070792. PMID 17804670.

[pmid27183443-22] Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG (2017). "Burns: Pathophysiology of Systemic Complications and Current Management". J Burn Care Res. 38 (1): e469–e481. doi:10.1097/BCR.0000000000000355. PMC 5214064. PMID 27183443.

[pmid9048354-23] Bates CM, Baum M, Quigley R (February 1997). "Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent". J. Am. Soc. Nephrol. 8 (2): 352–5. PMID 9048354.

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@@ Line 12: / Line 12: @@
 ! colspan="2" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
 ! colspan="8" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
-! colspan="5" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
+! colspan="5" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para−clinical findings
 ! colspan="1" rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
 ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Additional findings
@@ Line 40: / Line 40: @@
 ! rowspan="7" style="background: #DCDCDC; text-align: center;" |[[Renal]] and [[adrenal disorders]]
 ! style="background: #DCDCDC; text-align: center;" |[[Loop diuretics|Loop diuretic use]]<ref name="pmid8199766">{{cite journal |vauthors=Bourke E, Delaney V |title=Prevention of hypokalemia caused by diuretics |journal=Heart Dis Stroke |volume=3 |issue=2 |pages=63–7 |date=1994 |pmid=8199766 |doi= |url=}}</ref>
-!+/-
+!+/−
-!-
+!−
 !+
-!-
+!−
-!+/-
+!+/−
 !↓
-!-
+!−
 !+
 ![[Metabolic alkalosis]]
 !↑[[Potassium|K]]
 !↑[[Sodium|Na]]
-!-
+!−
-!-
+!−
 !History of medication use
-!-
+!−
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Primary hyperaldosteronism]]<ref name="pmid28101185">{{cite journal| author=Wu C, Xin J, Xin M, Zou H, Jing L, Zhu C et al.| title=Hypokalemic myopathy in primary aldosteronism: A case report. | journal=Exp Ther Med | year= 2016 | volume= 12 | issue= 6 | pages= 4064-4066 | pmid=28101185 | doi=10.3892/etm.2016.3864 | pmc=5228118 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28101185  }}</ref>
 !+
-!-
+!−
 !+
-!-
+!−
 !+
 !↑
 ![[Facial flushing]]
-!-
+!−
 ![[Metabolic alkalosis]]
 !↑[[Potassium|K]], ↓[[Sodium|Na]]
@@ Line 75: / Line 75: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Cushing syndrome]]<ref name="pmid12381548">{{cite journal |vauthors=Torpy DJ, Mullen N, Ilias I, Nieman LK |title=Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion: a series of 58 cases |journal=Ann. N. Y. Acad. Sci. |volume=970 |issue= |pages=134–44 |date=September 2002 |pmid=12381548 |doi= |url=}}</ref>
 !+
-!+/-
+!+/−
-!+/-
+!+/−
-!-
+!−
-!-
+!−
 !↑
 ![[Plethora|Facial plethora]], [[Striae|purple striae]]
@@ Line 86: / Line 86: @@
 !↑[[Blood sugar|BS]]
 !Unilateral [[adrenal hyperplasia]]
-!-
+!−
-!'''Urinary free [[cortisol]] (24-hour)'''
+!'''Urinary free [[cortisol]] (24−hour)'''
 !Dorsicocervical [[fat pad]], [[obesity]], [[hirsutism]]
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Hemodialysis]]<ref name="pmid23946760">{{cite journal| author=Choi HY, Ha SK| title=Potassium balances in maintenance hemodialysis. | journal=Electrolyte Blood Press | year= 2013 | volume= 11 | issue= 1 | pages= 9-16 | pmid=23946760 | doi=10.5049/EBP.2013.11.1.9 | pmc=3741441 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23946760  }}</ref>
-!+/-
+!+/−
-!+/-
+!+/−
-!+/-
+!+/−
-!-
+!−
-!-
+!−
 !Normal
 ![[Pustular rash|Pustular lesions]]
-!-
+!−
 ![[Metabolic alkalosis]]
 !Normal
 !↓[[Sodium|Na]]
-!-
+!−
-!-
+!−
 !History
 ![[Carpal tunnel syndrome]]
@@ Line 109: / Line 109: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Bartter syndrome]]<ref name="pmid12920401">{{cite journal |vauthors=Hebert SC |title=Bartter syndrome |journal=Curr. Opin. Nephrol. Hypertens. |volume=12 |issue=5 |pages=527–32 |date=September 2003 |pmid=12920401 |doi=10.1097/01.mnh.0000088732.87142.43 |url=}}</ref>
 !+
-!-
+!−
 !+
-!-
+!−
-!+/-
+!+/−
 !Normal or ↓
-!-
+!−
-!-
+!−
 ![[Metabolic alkalosis]]
 !↑[[Potassium|K]], ↑[[Ca]], ↑[[Chloride|Cl]]
-!-
+!−
-!-
+!−
-!-
+!−
 ![[Bartter syndrome laboratory findings|Laboratory findings]]
 ![[Mental retardation]], [[sensorineural hearing loss]]
@@ Line 126: / Line 126: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Gitelman syndrome]]<ref name="pmid18667063">{{cite journal| author=Knoers NV, Levtchenko EN| title=Gitelman syndrome. | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue=  | pages= 22 | pmid=18667063 | doi=10.1186/1750-1172-3-22 | pmc=2518128 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18667063  }}</ref>
 !+
-!-
+!−
 !+
-!-
+!−
 !+
 !Normal
-!-
+!−
-!-
+!−
 ![[Metabolic alkalosis]]
 !↑[[Potassium|K]], ↓[[Ca]], ↑[[Chloride|Cl]]
-!-
+!−
-!-
+!−
-!-
+!−
 !Laboratory findings
 ![[Growth retardation]], [[tetany]], [[muscle cramp]]
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Liddle syndrome]]<ref name="pmid29534496">{{cite journal |vauthors=Tetti M, Monticone S, Burrello J, Matarazzo P, Veglio F, Pasini B, Jeunemaitre X, Mulatero P |title=Liddle Syndrome: Review of the Literature and Description of a New Case |journal=Int J Mol Sci |volume=19 |issue=3 |pages= |date=March 2018 |pmid=29534496 |pmc=5877673 |doi=10.3390/ijms19030812 |url=}}</ref>
-!-
+!−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
-!-
+!−
 !↑
-!-
+!−
-!+/-
+!+/−
 ![[Metabolic alkalosis]]
 !↑[[Potassium|K]], ↓[[Sodium|Na]]
 !↓'''[[Plasma renin activity|PRA]]''', ↓'''[[Aldosterone|PAC]]'''
-!-
+!−
-!-
+!−
 !Laboratory findings
 ![[Pseudohyperaldosteronism]]
@@ Line 161: / Line 161: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Gastrointestinal bleeding|GI bleeding]]<ref name="pmid22901631">{{cite journal| author=Asmar A, Mohandas R, Wingo CS| title=A physiologic-based approach to the treatment of a patient with hypokalemia. | journal=Am J Kidney Dis | year= 2012 | volume= 60 | issue= 3 | pages= 492-7 | pmid=22901631 | doi=10.1053/j.ajkd.2012.01.031 | pmc=4776048 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22901631  }}</ref>
 !+
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !↓
-!-
+!−
-!-
+!−
 !Normal
 !Normal
 ![[Anemia]]
-!-
+!−
-!-
+!−
 !Clinical findings
 ![[Orthostatic hypotension]], [[bradycardia]]
@@ Line 178: / Line 178: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Vomiting]]<ref name="pmid22169581">{{cite journal |vauthors=Cheungpasitporn W, Suksaranjit P, Chanprasert S |title=Pathophysiology of vomiting-induced hypokalemia and diagnostic approach |journal=Am J Emerg Med |volume=30 |issue=2 |pages=384 |date=February 2012 |pmid=22169581 |doi=10.1016/j.ajem.2011.10.005 |url=}}</ref>
 !+
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !↓
-!-
+!−
-!-
+!−
 ![[Metabolic alkalosis]]
 ![[Chloride|Cl]] <20 mEq/L
-!-
+!−
-!-
+!−
-!-
+!−
 !Clinical findings
 !Dry [[mucous membranes]], [[lethargy]]
@@ Line 195: / Line 195: @@
 ! style="background: #DCDCDC; text-align: center;" |Severe [[diarrhea]]<ref name="pmid28580600">{{cite journal |vauthors=Bazerbachi F, Haffar S, Szarka LA, Wang Z, Prokop LJ, Murad MH, Camilleri M |title=Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature |journal=Neurogastroenterol. Motil. |volume=29 |issue=11 |pages= |date=November 2017 |pmid=28580600 |doi=10.1111/nmo.13120 |url=}}</ref>
 !+
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !↓
-!-
+!−
-!-
+!−
 ![[Metabolic alkalosis]]
 ![[Potassium|K]]<20 mEq/L
-!-
+!−
-!-
+!−
-!-
+!−
 !Clinical findings
 !Dry [[mucous membranes]], [[lethargy]]
@@ Line 212: / Line 212: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Villous adenoma]]<ref name="pmid24199207">{{cite journal| author=Sanchez Garcia S, Villarejo Campos P, Manzanares Campillo Mdel C, Gil Rendo A, Muñoz Atienza V, García Santos EP et al.| title=Hypersecretory villous adenoma as the primary cause of an intestinal intussusception and McKittrick-Wheelock syndrome. | journal=Can J Gastroenterol | year= 2013 | volume= 27 | issue= 11 | pages= 621-2 | pmid=24199207 | doi= | pmc=3816940 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24199207  }}</ref>
 !+
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !↓
-!-
+!−
-!-
+!−
 !Normal
 ![[Potassium|K]] and [[Chloride|Cl]] <20 mEq/L
 ![[Anemia]]
-!-
+!−
-!-
+!−
 ![[Colonoscopy]]
 ![[Hematochezia]]
@@ Line 229: / Line 229: @@
 ! style="background: #DCDCDC; text-align: center;" |[[VIPoma]]<ref name="pmid3035922">{{cite journal |vauthors=Krejs GJ |title=VIPoma syndrome |journal=Am. J. Med. |volume=82 |issue=5B |pages=37–48 |date=May 1987 |pmid=3035922 |doi= |url=}}</ref>
 !+
-!+/-
+!+/−
-!-
+!−
 !+
-!-
+!−
 !↓
 ![[Facial flushing]], [[skin rash]]
@@ Line 239: / Line 239: @@
 ![[Potassium|K]]<20 mEq/L
 !'''[[Osmolarity|Stool osmolar gap]] '''<50 mOsm/kg
-!'''[[Endoscopic ultrasound]] for''' [[VIPoma|VIPomas]] of 2-3 mm
+!'''[[Endoscopic ultrasound]] for''' [[VIPoma|VIPomas]] of 2−3 mm
 ![[Pancreatic]] [[VIPoma|VIPomas]] >3 cm
 !Laboratory findings
@@ Line 246: / Line 246: @@
 ! rowspan="5" style="background: #DCDCDC; text-align: center;" |[[Neuropsychiatric|Neuropsychiatric disorders]]
 ! style="background: #DCDCDC; text-align: center;" |[[Polydipsia|Primary polydipsia]]<ref name="pmid25688318">{{cite journal| author=Gill M, McCauley M| title=Psychogenic polydipsia: the result, or cause of, deteriorating psychotic symptoms? A case report of the consequences of water intoxication. | journal=Case Rep Psychiatry | year= 2015 | volume= 2015 | issue=  | pages= 846459 | pmid=25688318 | doi=10.1155/2015/846459 | pmc=4320790 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25688318  }}</ref>
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !+
 !Normal
-!-
+!−
-!+/-
+!+/−
 !Normal
 !↓[[Osmolarity|Urine osmolarity]]
 !↓[[Sodium|Na]]
-!-
+!−
-!-
+!−
 !'''Water restriction test'''
 ![[Psychosis]]
@@ Line 264: / Line 264: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Central diabetes insipidus]]<ref name="pmid24707338">{{cite journal| author=Nguyen FN, Kar JK, Verduzco-Gutierrez M, Zakaria A| title=A case of hypokalemic paralysis in a patient with neurogenic diabetes insipidus. | journal=Neurohospitalist | year= 2014 | volume= 4 | issue= 2 | pages= 90-3 | pmid=24707338 | doi=10.1177/1941874413495702 | pmc=3975788 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24707338  }}</ref>
 !+
-!-
+!−
 !+
-!-
+!−
 !+
 !Normal or ↓
-!-
+!−
-!-
+!−
 !Normal
 !↓[[Osmolarity|Urine osmolarity]]
 !↑[[Sodium|Na]]
-!-
+!−
-!-
+!−
 !'''Water restriction test'''
 ![[Encephalopathy|Ischemic encephalopathy]]
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Bulimia nervosa]]<ref name="pmid15213788">{{cite journal| author=Rushing JM, Jones LE, Carney CP| title=Bulimia Nervosa: A Primary Care Review. | journal=Prim Care Companion J Clin Psychiatry | year= 2003 | volume= 5 | issue= 5 | pages= 217-224 | pmid=15213788 | doi= | pmc=419300 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15213788  }}</ref>
-!-
+!−
-!-
+!−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
 !Normal or ↓
 ![[Asteatotic Dermatitis|Asteatotic '''skin''']] '''[[Carotenodermia|C]]'''[[Carotenodermia|arotenodermia]]
-!-
+!−
 !Normal
 !↑[[Potassium|K]], ↓[[Chloride|Cl]]
-!-
+!−
-!-
+!−
-!-
+!−
 ![[Psychological analysis|Psychological interview]]
-! [[Parotid gland]] enlargement, [[lanugo]]-like hair
+! [[Parotid gland]] enlargement, [[lanugo]]−like hair
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Anorexia nervosa]]<ref name="pmid21670105">{{cite journal| author=Liang CC, Yeh HC| title=Hypokalemic nephropathy in anorexia nervosa. | journal=CMAJ | year= 2011 | volume= 183 | issue= 11 | pages= E761 | pmid=21670105 | doi=10.1503/cmaj.101790 | pmc=3153553 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21670105  }}</ref>
 !+
-!-
+!−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
 !↓
 ![[Xerosis]], [[Telogen effluvium|hair effluvium]]
-!-
+!−
 !Normal
 !↑[[Potassium|K]], ↓[[Chloride|Cl]]
-!-
+!−
-!-
+!−
-!-
+!−
 ![[Psychological analysis|Psychological interview]]
 ![[Orthostatic hypotension]], [[bradycardia]]
@@ Line 315: / Line 315: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Hypokalemic periodic paralysis]]<ref name="urlHypokalemic periodic paralysis | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program">{{cite web |url=https://rarediseases.info.nih.gov/diseases/6729/hypokalemic-periodic-paralysis |title=Hypokalemic periodic paralysis &#124; Genetic and Rare Diseases Information Center (GARD) – an NCATS Program |format= |work= |accessdate=}}</ref>
 !+
-!-
+!−
-!-
+!−
-!-
+!−
-!+/-
+!+/−
 !Normal or ↓
-!-
+!−
-!+/-
+!+/−
 ![[Metabolic alkalosis]]
 ![[Potassium|K]]<20 mEq/L
 ![[Thyrotoxicosis]], ↓[[Magnesium|Mg]], ↓[[Phosphor|Ph]]
-!-
+!−
-!-
+!−
 !Laboratory findings
 ![[Paralysis|Paralytic episodes]], [[arrhythmias]]
@@ Line 332: / Line 332: @@
 ! rowspan="6" style="background: #DCDCDC; text-align: center;" |[[Systemic diseases]]
 ! style="background: #DCDCDC; text-align: center;" |[[Hypothermia]]<ref name="pmid9795553">{{cite journal |vauthors=Zydlewski AW, Hasbargen JA |title=Hypothermia-induced hypokalemia |journal=Mil Med |volume=163 |issue=10 |pages=719–21 |date=October 1998 |pmid=9795553 |doi= |url=}}</ref>
-!-
+!−
-!-
+!−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
 !Normal
 ![[Frostbite]]
-!-
+!−
 !Normal
 !Normal
-!-
+!−
-!-
+!−
-!-
+!−
 !Clinical findings
 ![[Loss of consciousness|Impaired mental state]]
@@ Line 350: / Line 350: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Alcoholism]]<ref name="pmid12189007">{{cite journal |vauthors=Elisaf M, Liberopoulos E, Bairaktari E, Siamopoulos K |title=Hypokalaemia in alcoholic patients |journal=Drug Alcohol Rev |volume=21 |issue=1 |pages=73–6 |date=March 2002 |pmid=12189007 |doi=10.1080/09595230220119282 |url=}}</ref>
 !+
-!+/-
+!+/−
 !+
-!-
+!−
 !+
 !Normal or ↓
@@ Line 360: / Line 360: @@
 ![[Ketonuria]]
 ![[Anemia]]
-!-
+!−
-!-
+!−
 !Clinical findings
 ![[Digital clubbing]], [[gynecomastia]]
@@ Line 367: / Line 367: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Diabetic ketoacidosis]]<ref name="pmid25430801">{{cite journal| author=Davis SM, Maddux AB, Alonso GT, Okada CR, Mourani PM, Maahs DM| title=Profound hypokalemia associated with severe diabetic ketoacidosis. | journal=Pediatr Diabetes | year= 2016 | volume= 17 | issue= 1 | pages= 61-5 | pmid=25430801 | doi=10.1111/pedi.12246 | pmc=4896141 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25430801  }}</ref>
 !+
-!+/-
+!+/−
 !+
-!-
+!−
 !+
 !↓
 ![[Xerosis]]
-!-
+!−
 ![[Metabolic acidosis]]
 ![[Ketonuria]]
 !↑Serum [[ketone]], ↑ [[blood glucose]]
-!-
+!−
-!-
+!−
 !Laboratory findings
 !Dry [[mucous membranes]], [[shock]]
@@ Line 384: / Line 384: @@
 ! style="background: #DCDCDC; text-align: center;" |[[Hypomagnesemia]]<ref name="pmid17804670">{{cite journal |vauthors=Huang CL, Kuo E |title=Mechanism of hypokalemia in magnesium deficiency |journal=J. Am. Soc. Nephrol. |volume=18 |issue=10 |pages=2649–52 |date=October 2007 |pmid=17804670 |doi=10.1681/ASN.2007070792 |url=}}</ref>
 !+
-!-
+!−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
 !Normal
-!-
+!−
-!+/-
+!+/−
 ![[Metabolic alkalosis]]
-!-
+!−
 !↓[[Calcium|Ca]]
-!-
+!−
-!-
+!−
 !Laboratory findings
 ![[Trousseau's sign|Trousseau]] and [[Chvostek's Sign|Chvostek signs]]
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Burns]]<ref name="pmid27183443">{{cite journal| author=Nielson CB, Duethman NC, Howard JM, Moncure M, Wood JG| title=Burns: Pathophysiology of Systemic Complications and Current Management. | journal=J Burn Care Res | year= 2017 | volume= 38 | issue= 1 | pages= e469-e481 | pmid=27183443 | doi=10.1097/BCR.0000000000000355 | pmc=5214064 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27183443  }}</ref>
-!+/-
+!+/−
-!-
+!−
-!-
+!−
 !+
-!-
+!−
 !↓
 ![[Vesicle]] and bullae, [[erythema]]
 !+
 !Normal
-!-
+!−
 ![[Acute phase reactant]]
-!-
+!−
-!-
+!−
 !Clinical findings
 ![[Dehydration]]
 |-
 ! style="background: #DCDCDC; text-align: center;" |[[Cystic fibrosis]]<ref name="pmid9048354">{{cite journal |vauthors=Bates CM, Baum M, Quigley R |title=Cystic fibrosis presenting with hypokalemia and metabolic alkalosis in a previously healthy adolescent |journal=J. Am. Soc. Nephrol. |volume=8 |issue=2 |pages=352–5 |date=February 1997 |pmid=9048354 |doi= |url=}}</ref>
-!+/-
+!+/−
-!+/-
+!+/−
-!-
+!−
-!+/-
+!+/−
-!-
+!−
 !↓
 ![[Aquagenic wrinkling of the palms|Early aquagenic '''skin''' wrinkling]]
-!+/-
+!+/−
 !Normal
-!-
+!−
-!-
+!−
 ![[Pancreatitis]]
 ![[Pulmonary]] infiltration

Hypokalemia differential diagnosis: Difference between revisions

Revision as of 18:52, 6 June 2018

Overview

Differentiating Causes of Hypokalemia

Differentiating the diseases that can cause hypokalemia is as following table:

References

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