Myeloproliferative neoplasm risk factors: Difference between revisions
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There are no established risk factors for myeloproliferative neoplasm. | There are no established risk factors for myeloproliferative neoplasm. | ||
==Risk factors== | ==Risk factors== | ||
*'''Mutations''': Genetic mutations are the most important risk factors for development of myeloproliferative neoplasm. Mutations in ''JAK2'', ''CALR'', and ''MPL | *'''Mutations''': Genetic mutations are the most important risk factors for development of myeloproliferative neoplasm. Mutations in ''JAK2'', ''CALR'', and ''MPL'' are the most common risk factors for myeloproliferative neoplasms and are causative mutations in the disease. There are multiple other genetic mutations associated with myeloproliferative neoplasms (please see '''Causes''' section). | ||
*'''Age''': Age is a major risk factor for the development of myeloproliferative neoplasm. Aging is associated with the acquisition of mutations in cells, and these mutations can lead to the development of hematologic malignancies. | *'''Age''': Age is a major risk factor for the development of myeloproliferative neoplasm. Aging is associated with the acquisition of mutations in cells, and these mutations can lead to the development of hematologic malignancies. | ||
Revision as of 18:40, 19 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
There are no established risk factors for myeloproliferative neoplasm.
Risk factors
- Mutations: Genetic mutations are the most important risk factors for development of myeloproliferative neoplasm. Mutations in JAK2, CALR, and MPL are the most common risk factors for myeloproliferative neoplasms and are causative mutations in the disease. There are multiple other genetic mutations associated with myeloproliferative neoplasms (please see Causes section).
- Age: Age is a major risk factor for the development of myeloproliferative neoplasm. Aging is associated with the acquisition of mutations in cells, and these mutations can lead to the development of hematologic malignancies.
- Autoimmunity: A prior history of autoimmune disease is associated with a risk for developing myeloproliferative neoplasms.[1] The etiology for the link between autoimmunity and myeloproliferative neoplasm is thought to be antigenic stimulation which results in immune cell activation and aberrant proliferation. There is specifically an increased risk of myeloproliferative neoplasm is patients with:
- Crohn's disease: This carries a 2.9-fold increased risk.
- Immune thrombocytopenia purpura: This carries a 1.8-fold increased risk.
- Polymyalgia rheumatica: This carries a 1.7-fold increased risk.
- Giant cell arteritis: This carries a 5.9-fold increased risk.
- Reiter's reactive arthritis: This carries a 15.9-fold increased risk.
- Aplastic anemia: This carries a 7.8-fold increased risk.
References
- ↑ Kristinsson SY, Landgren O, Samuelsson J, Björkholm M, Goldin LR (2010). "Autoimmunity and the risk of myeloproliferative neoplasms". Haematologica. 95 (7): 1216–20. doi:10.3324/haematol.2009.020412. PMC 2895049. PMID 20053870.