Myeloproliferative neoplasm epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Incidence=== | ===Incidence=== | ||
The incidence of myeloproliferative neoplasm is approximately 7.8 per 100,000 individuals worldwide.<ref name="CDC">Centers for Disease Control and Prevention. WTC Health Program.Myeloid Malignancieshttp://www.cdc.gov/wtc/pdfs/WTCHP_PP_MyeloidMalignancies_02012014.pdf</ref> There are varying incidences for the different subtypes of myeloproliferative neoplasm. The incidence of polycythemia vera is 2 per 100,000 individuals.<ref name="pmid25980454">{{cite journal| author=Kiladjian JJ, Winton EF, Talpaz M, Verstovsek S| title=Ruxolitinib for the treatment of patients with polycythemia vera. | journal=Expert Rev Hematol | year= 2015 | volume= 8 | issue= 4 | pages= 391-401 | pmid=25980454 | doi=10.1586/17474086.2015.1045869 | pmc=4627585 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25980454 }} </ref> | * The incidence of myeloproliferative neoplasm is approximately 7.8 per 100,000 individuals worldwide.<ref name="CDC">Centers for Disease Control and Prevention. WTC Health Program.Myeloid Malignancieshttp://www.cdc.gov/wtc/pdfs/WTCHP_PP_MyeloidMalignancies_02012014.pdf</ref> There are varying incidences for the different subtypes of myeloproliferative neoplasm. The incidence of polycythemia vera is 2 per 100,000 individuals.<ref name="pmid25980454">{{cite journal| author=Kiladjian JJ, Winton EF, Talpaz M, Verstovsek S| title=Ruxolitinib for the treatment of patients with polycythemia vera. | journal=Expert Rev Hematol | year= 2015 | volume= 8 | issue= 4 | pages= 391-401 | pmid=25980454 | doi=10.1586/17474086.2015.1045869 | pmc=4627585 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25980454 }} </ref> This statistic includes all eight subtypes of myeloproliferative neoplasm. | ||
*The incidence of polycythemia vera is 0.4-2.8 per 100,000 persons per year.<ref name="pmid25810569">{{cite journal| author=Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J et al.| title=Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia. | journal=Indian J Med Paediatr Oncol | year= 2015 | volume= 36 | issue= 1 | pages= 3-16 | pmid=25810569 | doi=10.4103/0971-5851.151770 | pmc=4363847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810569 }} </ref> | |||
*The incidence of essential thrombocythemia is 0.38-1.7 per 100,000 persons per year.<ref name="pmid25810569">{{cite journal| author=Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J et al.| title=Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia. | journal=Indian J Med Paediatr Oncol | year= 2015 | volume= 36 | issue= 1 | pages= 3-16 | pmid=25810569 | doi=10.4103/0971-5851.151770 | pmc=4363847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810569 }} </ref> | |||
*The incidence of primary myelofibrosis is 0.1-1 per 100,000 persons per year.<ref name="pmid25810569">{{cite journal| author=Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J et al.| title=Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia. | journal=Indian J Med Paediatr Oncol | year= 2015 | volume= 36 | issue= 1 | pages= 3-16 | pmid=25810569 | doi=10.4103/0971-5851.151770 | pmc=4363847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810569 }} </ref> | |||
===Age=== | ===Age=== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
The incidence of myeloproliferative neoplasm is approximately 2.3-7.8 per 100,000 individuals worldwide.[1] [2]
Epidemiology and Demographics
Incidence
- The incidence of myeloproliferative neoplasm is approximately 7.8 per 100,000 individuals worldwide.[1] There are varying incidences for the different subtypes of myeloproliferative neoplasm. The incidence of polycythemia vera is 2 per 100,000 individuals.[3] This statistic includes all eight subtypes of myeloproliferative neoplasm.
- The incidence of polycythemia vera is 0.4-2.8 per 100,000 persons per year.[4]
- The incidence of essential thrombocythemia is 0.38-1.7 per 100,000 persons per year.[4]
- The incidence of primary myelofibrosis is 0.1-1 per 100,000 persons per year.[4]
Age
The prevalence of myeloproliferative neoplasm increases with age.[5] The average age of diagnosis is 60-70.
Gender
Males are more commonly affected with myeloproliferative neoplasm than females.[5] However, females are more likely to be affected by the abdominal symptoms of myeloproliferative neoplasm.[6] Females are also more likely to develop thrombocytopenia than males.[6]. Females have a shorter disease duration.
Race
The prevalence of myeloproliferative neoplasm does not vary by race.[5]
References
- ↑ 1.0 1.1 Centers for Disease Control and Prevention. WTC Health Program.Myeloid Malignancieshttp://www.cdc.gov/wtc/pdfs/WTCHP_PP_MyeloidMalignancies_02012014.pdf
- ↑ Kristinsson SY, Landgren O, Samuelsson J, Björkholm M, Goldin LR (2010). "Autoimmunity and the risk of myeloproliferative neoplasms". Haematologica. 95 (7): 1216–20. doi:10.3324/haematol.2009.020412. PMC 2895049. PMID 20053870.
- ↑ Kiladjian JJ, Winton EF, Talpaz M, Verstovsek S (2015). "Ruxolitinib for the treatment of patients with polycythemia vera". Expert Rev Hematol. 8 (4): 391–401. doi:10.1586/17474086.2015.1045869. PMC 4627585. PMID 25980454.
- ↑ 4.0 4.1 4.2 Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J; et al. (2015). "Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia". Indian J Med Paediatr Oncol. 36 (1): 3–16. doi:10.4103/0971-5851.151770. PMC 4363847. PMID 25810569.
- ↑ 5.0 5.1 5.2 Rollison DE, Howlader N, Smith MT, Strom SS, Merritt WD, Ries LA; et al. (2008). "Epidemiology of myelodysplastic syndromes and chronic myeloproliferative disorders in the United States, 2001-2004, using data from the NAACCR and SEER programs". Blood. 112 (1): 45–52. doi:10.1182/blood-2008-01-134858. PMID 18443215.
- ↑ 6.0 6.1 Geyer HL, Kosiorek H, Dueck AC, Scherber R, Slot S, Zweegman S; et al. (2017). "Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group". Haematologica. 102 (1): 85–93. doi:10.3324/haematol.2016.149559. PMC 5210236. PMID 27540137.