Interstitial nephritis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
It is thought that acute tubulointerstitial nephritis is mediated by hypersensitivity reaction to drugs such as antibiotics,NSAIDS, sulfa drugs, as well as Systemic disease, and Infections may play parts in the pathogenesis of ATN from activation of cascade of cellular injury toward collagenases and metalloproteinases | |||
activation and release of proinflammatory cytokines into the interstitium. | |||
==Pathophysiology== | ==Pathophysiology== | ||
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*The exact pathogenesis of [disease name] is not completely understood. | *The exact pathogenesis of [disease name] is not completely understood. | ||
OR | OR | ||
*It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [ | *It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothdeveesis 3]. | ||
*[Pathogen name] is usually transmitted via the [transmission route] route to the human host. | *[Pathogen name] is usually transmitted via the [transmission route] route to the human host. | ||
*Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell. | *Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell. | ||
Revision as of 01:03, 26 June 2018
Overview
It is thought that acute tubulointerstitial nephritis is mediated by hypersensitivity reaction to drugs such as antibiotics,NSAIDS, sulfa drugs, as well as Systemic disease, and Infections may play parts in the pathogenesis of ATN from activation of cascade of cellular injury toward collagenases and metalloproteinases
activation and release of proinflammatory cytokines into the interstitium.
Pathophysiology
Physiology
The normal physiology of [name of process] can be understood as follows:
Pathogenesis
- The exact pathogenesis of [disease name] is not completely understood.
OR
- It is understood that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothdeveesis 3].
- [Pathogen name] is usually transmitted via the [transmission route] route to the human host.
- Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
- [Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
- The progression to [disease name] usually involves the [molecular pathway].
- The pathophysiology of [disease/malignancy] depends on the histological subtype.