Interstitial nephritis history and symptoms: Difference between revisions
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== Overview == | == Overview == | ||
The majority of patients with | The majority of patients with TIN from any cause are [[asymptomatic]]; however, vague [[Sign and symptom|signs and symptoms]] of [[acute kidney injury|acute or chronic kidney injury]] may present. | ||
Nevertheless, presence of symptoms or signs of a [[hypersensitivity reaction]], such as [[rash]], [[fever]], and [[eosinophilia]] in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN. | Nevertheless, presence of symptoms or signs of a [[hypersensitivity reaction]], such as [[rash]], [[fever]], and [[eosinophilia]] in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN. | ||
==History and Symptoms== | ==History and Symptoms== | ||
* The majority of patients with | * The majority of patients with TIN are asymptomatic.<ref>Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial | ||
nephritis. Am Fam Physician 2003; 67:2527</ref> | nephritis. Am Fam Physician 2003; 67:2527</ref> however, when the nonspicific [[Sign and symptom|signs and symptoms]] do occur they are widely varied and can occur rapidly or gradually.<ref name="pmid11473672">{{cite journal |author=Rossert J |title=Drug-induced acute interstitial nephritis |journal=Kidney Int |volume=60 |issue=2 |pages=804-17 |year=2001 |pmid=11473672 | url=http://www.nature.com/ki/journal/v60/n2/full/4492487a.html | doi=10.1046/j.1523-1755.2001.060002804.x}}</ref><ref name="pmid14671029">.</ref><ref name="pmid6604293">{{cite journal |author=Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J |title=Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy |journal=Q J Med |volume=52 |issue=206 |pages=194-211 |year=1983 |pmid=6604293}}</ref><ref name="pmid3779558">{{cite journal |author=Handa S |title=Drug-induced acute interstitial nephritis: report of 10 cases |journal=CMAJ |volume=135 |issue=11 |pages=1278-81 |year=1986 |pmid=3779558}}</ref><ref name="pmid2113219">{{cite journal |author=Buysen J, Houthoff H, Krediet R, Arisz L |title=Acute interstitial nephritis: a clinical and morphological study in 27 patients |journal=Nephrol Dial Transplant |volume=5 |issue=2 |pages=94-9 |year=1990 |pmid=2113219}}</ref> When caused by an allergic-type reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),<ref name="pmid14671029" /> rash (15% of patients),<ref name="pmid14671029" /> and eosinophilia. | ||
* Some people experience [[dysuria]], and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include [[hyperkalemia]], [[metabolic acidosis]], and [[kidney failure]]. | |||
=== History === | |||
* | Patients with TIN may have a positive history of: | ||
* Drugs consumption especially antibiotic as well NSAIDS | |||
=== History | * Previous history of allergic drug reaction | ||
Patients with | * infections | ||
* | * Systemic disease including sarcoidosis, Sjögren's syndrome, systemic lupus erythematosus (SLE), | ||
* | |||
* | |||
=== Common Symptoms[edit | edit source] === | === Common Symptoms[edit | edit source] === | ||
Common symptoms of | Common symptoms of TIN include: | ||
* | * The acute or subacute onset of nausea, vomiting, and malaise owing to acute renal dysfunction | ||
* Oliguria | |||
* . | |||
=== Less Common Symptoms[edit | edit source] === | |||
Less common symptoms of TIN include: | |||
* Gross hematuria (5% of patients) | |||
* proteinuria (<1% of patients) | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohsen Basiri M.D.
Overview
The majority of patients with TIN from any cause are asymptomatic; however, vague signs and symptoms of acute or chronic kidney injury may present.
Nevertheless, presence of symptoms or signs of a hypersensitivity reaction, such as rash, fever, and eosinophilia in the history of consumption of the culprit drugs causing AIN should raise the clinical suspicion for drug-induced AIN.
History and Symptoms
- The majority of patients with TIN are asymptomatic.[1] however, when the nonspicific signs and symptoms do occur they are widely varied and can occur rapidly or gradually.[2][3][4][5][6] When caused by an allergic-type reaction, the symptoms of acute tubulointerstitial nephritis are fever (27% of patients),[3] rash (15% of patients),[3] and eosinophilia.
- Some people experience dysuria, and lower back pain. In chronic tubulointerstitial nephritis the patient can experience symptoms such as nausea, vomiting, fatigue, and weight loss. Other conditions that may develop include hyperkalemia, metabolic acidosis, and kidney failure.
History
Patients with TIN may have a positive history of:
- Drugs consumption especially antibiotic as well NSAIDS
- Previous history of allergic drug reaction
- infections
- Systemic disease including sarcoidosis, Sjögren's syndrome, systemic lupus erythematosus (SLE),
Common Symptoms[edit | edit source]
Common symptoms of TIN include:
- The acute or subacute onset of nausea, vomiting, and malaise owing to acute renal dysfunction
- Oliguria
- .
Less Common Symptoms[edit | edit source]
Less common symptoms of TIN include:
- Gross hematuria (5% of patients)
- proteinuria (<1% of patients)
References
- ↑ Kodner CM, Kudrimoti A. Diagnosis and management of acute interstitial nephritis. Am Fam Physician 2003; 67:2527
- ↑ Rossert J (2001). "Drug-induced acute interstitial nephritis". Kidney Int. 60 (2): 804–17. doi:10.1046/j.1523-1755.2001.060002804.x. PMID 11473672.
- ↑ 3.0 3.1 3.2 .
- ↑ Pusey C, Saltissi D, Bloodworth L, Rainford D, Christie J (1983). "Drug associated acute interstitial nephritis: clinical and pathological features and the response to high dose steroid therapy". Q J Med. 52 (206): 194–211. PMID 6604293.
- ↑ Handa S (1986). "Drug-induced acute interstitial nephritis: report of 10 cases". CMAJ. 135 (11): 1278–81. PMID 3779558.
- ↑ Buysen J, Houthoff H, Krediet R, Arisz L (1990). "Acute interstitial nephritis: a clinical and morphological study in 27 patients". Nephrol Dial Transplant. 5 (2): 94–9. PMID 2113219.